Avian Bornaviruses in Psittacine Birds from Europe and Australia with Proventricular Dilatation Disease

To determine whether avian bornaviruses (ABVs) were a factor in proventricular dilatation disease (PDD), we used immunohistochemistry, reverse transcription-PCR, and nucleotide sequence analysis to examine paraffin wax-embedded or frozen tissue samples of 31 psittacine birds with this disease. PDD i...

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Bibliographic Details
Published in:Emerging infectious diseases Vol. 15; no. 9; pp. 1453 - 1459
Main Authors: Weissenböck, Herbert, Bakonyi, Tamás, Sekulin, Karin, Ehrensperger, Felix, Doneley, Robert J.T., Dürrwald, Ralf, Hoop, Richard, Erdélyi, Károly, Gál, János, Kolodziejek, Jolanta, Nowotny, Norbert
Format: Journal Article
Language:English
Published: United States U.S. National Center for Infectious Diseases 01.09.2009
Centers for Disease Control and Prevention
Subjects:
Amino Acid Sequence
Analysis
Animals
Australia - epidemiology
Aves
avian bornavirus
Bird Diseases - epidemiology
Bird Diseases - virology
Borna disease virus
Bornaviridae - classification
Bornaviridae - genetics
Bornaviridae - isolation & purification
Bornaviridae - pathogenicity
Dilatation, Pathologic - epidemiology
Dilatation, Pathologic - veterinary
Dilatation, Pathologic - virology
Encephalitis
Europe - epidemiology
Glycoproteins - genetics
Immunohistochemistry
Molecular Sequence Data
Mononegavirales Infections - epidemiology
Mononegavirales Infections - veterinary
Mononegavirales Infections - virology
PDD
Proventricular dilatation disease
Proventriculus - virology
Psittaciformes - virology
psittacine birds
RNA, Viral - analysis
RNA, Viral - isolation & purification
Sequence Analysis, DNA
Species Specificity
Viral antigens
Viral Proteins - genetics
viruses
Australia
Europe
ISSN:1080-6040, 1080-6059, 1080-6059
Online Access:Get full text
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Summary:To determine whether avian bornaviruses (ABVs) were a factor in proventricular dilatation disease (PDD), we used immunohistochemistry, reverse transcription-PCR, and nucleotide sequence analysis to examine paraffin wax-embedded or frozen tissue samples of 31 psittacine birds with this disease. PDD is a fatal disease of psittacine birds associated with nonsuppurative encephalitis and ganglioneuritis of the upper intestinal tract. Tissue samples had been collected from 1999 through 2008 in Austria, Switzerland, Hungary, and Australia. Immunohistochemical demonstration of viral antigen within the brain and vegetative nerve system of the gastrointestinal tract provides strong evidence for a causative role of ABVs in this condition. Partial sequences of nucleoprotein (p40) and matrix protein (gp18) genes showed that virus in most of our cases belonged to the ABV-2 and ABV-4 groups among the 5 genogroups described so far. Viral sequences of 2 birds did not match any of the described sequences and clustered together in a new branch termed ABV-6.
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ISSN:1080-6040
1080-6059
1080-6059
DOI:10.3201/eid1509.090353