single mutation in the GSTe2 gene allows tracking of metabolically based insecticide resistance in a major malaria vector

BACKGROUND: Metabolic resistance to insecticides is the biggest threat to the continued effectiveness of malaria vector control. However, its underlying molecular basis, crucial for successful resistance management, remains poorly characterized. RESULTS: Here, we demonstrate that the single amino ac...

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Bibliographic Details
Published in:	Genome biology Vol. 15; no. 2; pp. R27 - 27
Main Authors:	Riveron, Jacob M, Yunta, Cristina, Ibrahim, Sulaiman S, Djouaka, Rousseau, Irving, Helen, Menze, Benjamin D, Ismail, Hanafy M, Hemingway, Janet, Ranson, Hilary, Albert, Armando, Wondji, Charles S
Format:	Journal Article
Language:	English
Published:	London Springer-Verlag 25.02.2014 BioMed Central
Subjects:	Africa Alleles Animal Genetics and Genomics Animals Anopheles - drug effects Anopheles - genetics Anopheles funestus Benin Bioinformatics Biomedical and Life Sciences cross resistance Crystallography, X-Ray DDT (pesticide) DDT - toxicity Drosophila melanogaster evolution Evolutionary Biology gene expression regulation gene flow gene overexpression genes geographical distribution glutathione transferase Glutathione Transferase - chemistry Glutathione Transferase - genetics Human Genetics Humans Insect Vectors - drug effects Insect Vectors - genetics insecticide resistance Insecticide Resistance - genetics Life Sciences malaria Malaria - genetics Malaria - transmission Microbial Genetics and Genomics Molecular Sequence Data Mutation permethrin Plant Genetics and Genomics point mutation Pyrethrins - metabolism resistance management vector control Benin Africa Root Mean Square Deviation Pyrethroid Resistance Indoor Residual Spray Deltamethrin L119F Mutation
ISSN:	1465-6906, 1474-760X, 1465-6914, 1474-760X
Online Access:	Get full text
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