Cross-species comparison of aCGH data from mouse and human BRCA1- and BRCA2-mutated breast cancers

Background Genomic gains and losses are a result of genomic instability in many types of cancers. BRCA1 - and BRCA2 -mutated breast cancers are associated with increased amounts of chromosomal aberrations, presumably due their functions in genome repair. Some of these genomic aberrations may harbor...

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Veröffentlicht in:	BMC cancer Jg. 10; H. 1; S. 455
Hauptverfasser:	Holstege, Henne, van Beers, Erik, Velds, Arno, Liu, Xiaoling, Joosse, Simon A, Klarenbeek, Sjoerd, Schut, Eva, Kerkhoven, Ron, Klijn, Christiaan N, Wessels, Lodewyk FA, Nederlof, Petra M, Jonkers, Jos
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London BioMed Central 24.08.2010 BioMed Central Ltd Springer Nature B.V BMC
Schlagworte:	Animals Artificial chromosomes Biology Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Biomedical and Life Sciences Biomedicine BRCA mutations BRCA1 Protein - genetics BRCA2 Protein - genetics Breast cancer Breast Neoplasms - classification Breast Neoplasms - genetics Breast Neoplasms - pathology Cancer Research Chromosome Aberrations Comparative Genomic Hybridization Computer science Deoxyribonucleic acid DNA Female Females Gene Expression Profiling Genetic aspects Genetic testing Genetics Genomes Genomic Instability genomics and epigenetics Health aspects Health Promotion and Disease Prevention Humans Hybridization Medicine/Public Health Mice Mutation - genetics Oligonucleotide Array Sequence Analysis Oncology Research Article Reverse Transcriptase Polymerase Chain Reaction Risk factors RNA, Messenger - genetics Species Specificity Statistical analysis Statistical methods Surgical Oncology Tumors Netherlands China aCGH Data Bacterial Artificial Chromosome Clone Mammary Tumor Carcinosarcoma Tumor Group
ISSN:	1471-2407, 1471-2407
Online-Zugang:	Volltext
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