Targeting hepatic glutaminase activity to ameliorate hyperglycemia

In mice, elevated glucagon during type 2 diabetes promotes more hepatic glutamine flux and greater gluconeogenesis, while reducing glutamine metabolism in the liver lowers hyperglycemia. Glucagon levels increase under homeostatic, fasting conditions, promoting the release of glucose from the liver b...

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Veröffentlicht in:	Nature medicine Jg. 24; H. 4; S. 518 - 524
Hauptverfasser:	Miller, Russell A, Shi, Yuji, Lu, Wenyun, Pirman, David A, Jatkar, Aditi, Blatnik, Matthew, Wu, Hong, Cárdenas, César, Wan, Min, Foskett, J Kevin, Park, Junyoung O, Zhang, Yiyi, Holland, William L, Rabinowitz, Joshua D, Birnbaum, Morris J
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York Springer New York 01.04.2018 Nature Publishing Group
Schlagworte:	13/95 631/337 631/443/163 631/443/319/1642/2037 631/443/319/320 82/58 Amino acids Animals Biomedicine Blood levels Calcium (reticular) Cancer Research Carbon Care and treatment Cells, Cultured Cryopreservation Development and progression Diabetes mellitus Diabetes mellitus (non-insulin dependent) Endoplasmic reticulum Fasting Fluctuations Flux Genetic diversity Genome-wide association studies Genomes Glucagon Glucagon - metabolism Gluconeogenesis Glucose Glutaminase Glutaminase - metabolism Glutamine Glutamine - metabolism Glycogen Glycogens Health aspects Hepatocytes Hepatocytes - metabolism Hepatology Humans Hydrolases Hyperglycemia Hyperglycemia - enzymology Infectious Diseases Insulin Ketoglutaric acid Kinases Kinetics Labeling letter Liver Liver - enzymology Metabolic Diseases Metabolic Flux Analysis Metabolism Metabolites Mice, Inbred C57BL Mice, Knockout Missense mutation Mitochondria Molecular Medicine Mutation Neurosciences Oxoglutarate dehydrogenase (lipoamide) Phosphorylation Physiological aspects Protein kinase A Proteins Signaling
ISSN:	1078-8956, 1546-170X, 1546-170X
Online-Zugang:	Volltext
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