A computational algorithm for optimal design of a bioartificial organ scaffold architecture

We develop a computational algorithm based on a diffuse interface approach to study the design of bioartificial organ scaffold architectures. These scaffolds, composed of poroelastic hydrogels housing transplanted cells, are linked to the patient’s blood circulation via an anastomosis graft. Before...

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Bibliographic Details
Published in:	PLoS computational biology Vol. 20; no. 11; p. e1012079
Main Authors:	Bukač, Martina, Čanić, Sunčica, Muha, Boris, Wang, Yifan
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.11.2024 Public Library of Science (PLoS)
Subjects:	Advection Algorithms Analysis Anastomosis Artificial organs Bioartificial Organs Biology and Life Sciences Blood circulation Blood flow Blood plasma Cell viability Computational Biology - methods Computer applications Computer Simulation Design Design and construction Design optimization Fabrication Geometry Humans Hydrogels Hydrogels - chemistry Hypoxia Insulin Kinematics Medicine and Health Sciences Nutrients Oxygen Oxygen - metabolism Pancreas Physical Sciences Plasma Plasma physics Poroelasticity Reaction-diffusion equations Research and Analysis Methods Rheological properties Rheology Scaffolds Science education Simulation Stem cells Time dependence Tissue Engineering - methods Tissue Scaffolds - chemistry Velocity United States Croatia
ISSN:	1553-7358, 1553-734X, 1553-7358
Online Access:	Get full text
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