Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs

Livestock diseases caused by Trypanosoma congolense , T . vivax and T . brucei , collectively known as nagana, are responsible for billions of dollars in lost food production annually. There is an urgent need for novel therapeutics. Encouragingly, promising antitrypanosomal benzoxaboroles are under...

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Bibliographic Details
Published in:	PLoS pathogens Vol. 16; no. 11; p. e1008932
Main Authors:	Giordani, Federica, Paape, Daniel, Vincent, Isabel M., Pountain, Andrew W., Fernández-Cortés, Fernando, Rico, Eva, Zhang, Ning, Morrison, Liam J., Freund, Yvonne, Witty, Michael J., Peter, Rosemary, Edwards, Darren Y., Wilkes, Jonathan M., van der Hooft, Justin J. J., Regnault, Clément, Read, Kevin D., Horn, David, Field, Mark C., Barrett, Michael P.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 03.11.2020 Public Library of Science (PLoS)
Subjects:	Aldehyde dehydrogenase Aldehydes Analysis Animals Biology and Life Sciences Boron Compounds - metabolism Carboxylic Acids - metabolism Carboxypeptidase Carboxypeptidases - metabolism Chemical compounds Chemical properties Chromosome 10 Chromosomes Cloning Dosage and administration Drug dosages Drug Resistance Drug therapy Drugs Enzyme activation Female Forecasts and trends Gene sequencing Genes Genomes Identification and classification Infectious diseases Influence Livestock Metabolism Metabolomics Methionine Methylation Mice Nucleotide sequence Parasitemia - veterinary Parasites Peptidase Peptidases Peptides Physical Sciences Prodrugs Prodrugs - metabolism Proteases Protozoan Proteins - metabolism Research and Analysis Methods RNA processing Serine Serine carboxypeptidase Splicing Synteny Trypanocidal Agents - metabolism Trypanosoma Trypanosoma brucei brucei - drug effects Trypanosoma brucei brucei - enzymology Trypanosoma congolense - drug effects Trypanosoma congolense - enzymology Trypanosoma vivax - drug effects Trypanosoma vivax - enzymology Trypanosomiasis, African - drug therapy Trypanosomiasis, African - parasitology Trypanosomiasis, African - veterinary Valine - analogs & derivatives Valine - metabolism Veterinary research Whole genome sequencing United Kingdom
ISSN:	1553-7374, 1553-7366, 1553-7374
Online Access:	Get full text
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