Ubiquitin variants potently inhibit SARS-CoV-2 PLpro and viral replication via a novel site distal to the protease active site

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has made it clear that combating coronavirus outbreaks benefits from a combination of vaccines and therapeutics. A promising drug target common to all coronaviruses—including SARS-CoV, MERS-CoV, and SARS-CoV-2—is the papain-li...

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Bibliographic Details
Published in:	PLoS pathogens Vol. 18; no. 12; p. e1011065
Main Authors:	van Vliet, Vera J. E., Huynh, Nhan, Palà, Judith, Patel, Ankoor, Singer, Alex, Slater, Cole, Chung, Jacky, van Huizen, Mariska, Teyra, Joan, Miersch, Shane, Luu, Gia-Khanh, Ye, Wei, Sharma, Nitin, Ganaie, Safder S., Russell, Raquel, Chen, Chao, Maynard, Mindy, Amarasinghe, Gaya K., Mark, Brian L., Kikkert, Marjolein, Sidhu, Sachdev S.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.12.2022 Public Library of Science (PLoS)
Subjects:	Antiviral agents Antiviral drugs Biology and life sciences Catalytic Domain Cell culture Cloning Coronaviruses COVID-19 COVID-19 vaccines Crystal structure Disease transmission Enzymes Genomes Health aspects Humans Immune response Innate immunity Medicine and health sciences Middle East respiratory syndrome Pandemics Papain Papain - chemistry Papain - metabolism Peptide Hydrolases - metabolism Phages Physiological aspects Polyproteins Protease Proteases Proteins Replicase Replication Research and analysis methods SARS-CoV-2 - metabolism Severe acute respiratory syndrome coronavirus 2 Substrates Therapeutic targets Ubiquitin Ubiquitin - metabolism Vaccines Viral diseases Virus Replication Virus research Viruses Netherlands
ISSN:	1553-7374, 1553-7366, 1553-7374
Online Access:	Get full text
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