CAR/CXCR5-T cell immunotherapy is safe and potentially efficacious in promoting sustained remission of SIV infection

During chronic human immunodeficiency virus (HIV) or simian immunodeficiency virus (SIV) infection prior to AIDS progression, the vast majority of viral replication is concentrated within B cell follicles of secondary lymphoid tissues. We investigated whether infusion of T cells expressing an SIV-sp...

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Bibliographic Details
Published in:	PLoS pathogens Vol. 18; no. 2; p. e1009831
Main Authors:	Pampusch, Mary S., Abdelaal, Hadia M., Cartwright, Emily K., Molden, Jhomary S., Davey, Brianna C., Sauve, Jordan D., Sevcik, Emily N., Rendahl, Aaron K., Rakasz, Eva G., Connick, Elizabeth, Berger, Edward A., Skinner, Pamela J.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.02.2022 Public Library of Science (PLoS)
Subjects:	Animals Antigen receptors, T cell Antigens Antiretroviral therapy Antiviral drugs B-Lymphocytes - immunology Biology and Life Sciences Bone marrow CD4 antigen CD4-Positive T-Lymphocytes - immunology CD8 antigen CD8-Positive T-Lymphocytes - immunology Cell migration Chemokine receptors Chemokines Chimeric antigen receptors Chronic infection Control CXCR5 protein Dendritic cells Drug resistance Follicles Genetic modification Germinal Center - immunology Glycoproteins Health aspects HIV Human immunodeficiency virus Humans Ileum Immune system Immunotherapy Infections Localization Lymph nodes Lymph Nodes - immunology Lymphatic system Lymphocytes Lymphocytes T Lymphoid tissue Macaca mulatta Medicine and Health Sciences Receptors Receptors, Chimeric Antigen - immunology Receptors, Chimeric Antigen - metabolism Receptors, CXCR5 - immunology Receptors, CXCR5 - metabolism Rectum Remission Research and Analysis Methods Ribonucleic acid RNA RNA, Viral Simian Acquired Immunodeficiency Syndrome - immunology Simian Acquired Immunodeficiency Syndrome - therapy Simian immunodeficiency virus Simian Immunodeficiency Virus - immunology Small intestine Spleen T cells Testing Viral Load Viruses United States
ISSN:	1553-7374, 1553-7366, 1553-7374
Online Access:	Get full text
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