Chromulinavorax destructans, a pathogen of microzooplankton that provides a window into the enigmatic candidate phylum Dependentiae

Members of the major candidate phylum Dependentiae (a.k.a. TM6) are widespread across diverse environments from showerheads to peat bogs; yet, with the exception of two isolates infecting amoebae, they are only known from metagenomic data. The limited knowledge of their biology indicates that they h...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	PLoS pathogens Ročník 15; číslo 5; s. e1007801
Hlavní autori:	Deeg, Christoph M., Zimmer, Matthias M., George, Emma E., Husnik, Filip, Keeling, Patrick J., Suttle, Curtis A.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Public Library of Science 01.05.2019 Public Library of Science (PLoS)
Predmet:	Amoeba Animals Ankyrins Atmospheric sciences Bacteria Bacteria - classification Bacteria - genetics Bacteria - pathogenicity Bioinformatics Biological evolution Biology Biology and Life Sciences Bogs Chrysophyta - microbiology Computer and Information Sciences Dependence Flagellates Flow cytometry Genes Genetic aspects Genome, Bacterial Genomes Host Microbial Interactions Host-bacteria relationships Immunology Infections Integrated software Metabolic pathways Microscopy Nutrients Parasites Parasitism Pathogens Peat Peat bogs Phylogenetics Phylogeny Physiological aspects Proteins Research and Analysis Methods Secretion Supervision Viruses Zooplankton Zooplankton - microbiology Canada
ISSN:	1553-7374, 1553-7366, 1553-7374
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Abstract	Members of the major candidate phylum Dependentiae (a.k.a. TM6) are widespread across diverse environments from showerheads to peat bogs; yet, with the exception of two isolates infecting amoebae, they are only known from metagenomic data. The limited knowledge of their biology indicates that they have a long evolutionary history of parasitism. Here, we present Chromulinavorax destructans (Strain SeV1) the first isolate of this phylum to infect a representative from a widespread and ecologically significant group of heterotrophic flagellates, the microzooplankter Spumella elongata (Strain CCAP 955/1). Chromulinavorax destructans has a reduced 1.2 Mb genome that is so specialized for infection that it shows no evidence of complete metabolic pathways, but encodes an extensive transporter system for importing nutrients and energy in the form of ATP from the host. Its replication causes extensive reorganization and expansion of the mitochondrion, effectively surrounding the pathogen, consistent with its dependency on the host for energy. Nearly half (44%) of the inferred proteins contain signal sequences for secretion, including many without recognizable similarity to proteins of known function, as well as 98 copies of proteins with an ankyrin-repeat domain; ankyrin-repeats are known effectors of host modulation, suggesting the presence of an extensive host-manipulation apparatus. These observations help to cement members of this phylum as widespread and diverse parasites infecting a broad range of eukaryotic microbes.
AbstractList	Members of the major candidate phylum Dependentiae (a.k.a. TM6) are widespread across diverse environments from showerheads to peat bogs; yet, with the exception of two isolates infecting amoebae, they are only known from metagenomic data. The limited knowledge of their biology indicates that they have a long evolutionary history of parasitism. Here, we present Chromulinavorax destructans (Strain SeV1) the first isolate of this phylum to infect a representative from a widespread and ecologically significant group of heterotrophic flagellates, the microzooplankter Spumella elongata (Strain CCAP 955/1). Chromulinavorax destructans has a reduced 1.2 Mb genome that is so specialized for infection that it shows no evidence of complete metabolic pathways, but encodes an extensive transporter system for importing nutrients and energy in the form of ATP from the host. Its replication causes extensive reorganization and expansion of the mitochondrion, effectively surrounding the pathogen, consistent with its dependency on the host for energy. Nearly half (44%) of the inferred proteins contain signal sequences for secretion, including many without recognizable similarity to proteins of known function, as well as 98 copies of proteins with an ankyrin-repeat domain; ankyrin-repeats are known effectors of host modulation, suggesting the presence of an extensive host-manipulation apparatus. These observations help to cement members of this phylum as widespread and diverse parasites infecting a broad range of eukaryotic microbes. Members of the major candidate phylum Dependentiae (a.k.a. TM6) are widespread across diverse environments from showerheads to peat bogs; yet, with the exception of two isolates infecting amoebae, they are only known from metagenomic data. The limited knowledge of their biology indicates that they have a long evolutionary history of parasitism. Here, we present Chromulinavorax destructans (Strain SeV1) the first isolate of this phylum to infect a representative from a widespread and ecologically significant group of heterotrophic flagellates, the microzooplankter Spumella elongata (Strain CCAP 955/1). Chromulinavorax destructans has a reduced 1.2 Mb genome that is so specialized for infection that it shows no evidence of complete metabolic pathways, but encodes an extensive transporter system for importing nutrients and energy in the form of ATP from the host. Its replication causes extensive reorganization and expansion of the mitochondrion, effectively surrounding the pathogen, consistent with its dependency on the host for energy. Nearly half (44%) of the inferred proteins contain signal sequences for secretion, including many without recognizable similarity to proteins of known function, as well as 98 copies of proteins with an ankyrin-repeat domain; ankyrin-repeats are known effectors of host modulation, suggesting the presence of an extensive host-manipulation apparatus. These observations help to cement members of this phylum as widespread and diverse parasites infecting a broad range of eukaryotic microbes. Little is known about the biology of bacteria in the candidate phylum Dependentiae, despite being widespread in nature. Here, we describe a novel isolate of this phylum, Chromulinavorax destructans, which infects an abundant aquatic predatory protist, Spumella elongata. Chromulinavorax destructans is an obligate intracellular parasite, forgoes binary fission and replicates surrounded by the host mitochondrion. The genome of C. destructans encodes no detectable complete metabolic pathways and instead contains extensive transporter systems to import metabolites and even energy in the form of ATP from the host. We also found a surprising number of genes in the C. destructans genome encoding putative host modifying proteins that might be responsible for the extensive host reorganization. Phylogenetic analysis showed that C. destructans is distantly related to intracellular pathogens and symbionts of unrelated amoebae. Hence, Chromulinavorax destructans provides new insights into the biology of a widespread but largely unknown phylum of bacteria. These results imply that members of the Dependentiae are pathogens of diverse aquatic protists and are therefore likely important players in aquatic ecosystems. Members of the major candidate phylum Dependentiae (a.k.a. TM6) are widespread across diverse environments from showerheads to peat bogs; yet, with the exception of two isolates infecting amoebae, they are only known from metagenomic data. The limited knowledge of their biology indicates that they have a long evolutionary history of parasitism. Here, we present Chromulinavorax destructans (Strain SeV1) the first isolate of this phylum to infect a representative from a widespread and ecologically significant group of heterotrophic flagellates, the microzooplankter Spumella elongata (Strain CCAP 955/1). Chromulinavorax destructans has a reduced 1.2 Mb genome that is so specialized for infection that it shows no evidence of complete metabolic pathways, but encodes an extensive transporter system for importing nutrients and energy in the form of ATP from the host. Its replication causes extensive reorganization and expansion of the mitochondrion, effectively surrounding the pathogen, consistent with its dependency on the host for energy. Nearly half (44%) of the inferred proteins contain signal sequences for secretion, including many without recognizable similarity to proteins of known function, as well as 98 copies of proteins with an ankyrin-repeat domain; ankyrin-repeats are known effectors of host modulation, suggesting the presence of an extensive host-manipulation apparatus. These observations help to cement members of this phylum as widespread and diverse parasites infecting a broad range of eukaryotic microbes.Members of the major candidate phylum Dependentiae (a.k.a. TM6) are widespread across diverse environments from showerheads to peat bogs; yet, with the exception of two isolates infecting amoebae, they are only known from metagenomic data. The limited knowledge of their biology indicates that they have a long evolutionary history of parasitism. Here, we present Chromulinavorax destructans (Strain SeV1) the first isolate of this phylum to infect a representative from a widespread and ecologically significant group of heterotrophic flagellates, the microzooplankter Spumella elongata (Strain CCAP 955/1). Chromulinavorax destructans has a reduced 1.2 Mb genome that is so specialized for infection that it shows no evidence of complete metabolic pathways, but encodes an extensive transporter system for importing nutrients and energy in the form of ATP from the host. Its replication causes extensive reorganization and expansion of the mitochondrion, effectively surrounding the pathogen, consistent with its dependency on the host for energy. Nearly half (44%) of the inferred proteins contain signal sequences for secretion, including many without recognizable similarity to proteins of known function, as well as 98 copies of proteins with an ankyrin-repeat domain; ankyrin-repeats are known effectors of host modulation, suggesting the presence of an extensive host-manipulation apparatus. These observations help to cement members of this phylum as widespread and diverse parasites infecting a broad range of eukaryotic microbes.
Audience	Academic
Author	Zimmer, Matthias M. Suttle, Curtis A. Deeg, Christoph M. George, Emma E. Keeling, Patrick J. Husnik, Filip
AuthorAffiliation	2 Department of Earth, Ocean and Atmospheric Sciences, University of British Columbia, Vancouver, Canada 3 Department of Botany, University of British Columbia, Vancouver, Canada 1 Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada Pennsylvania State University, UNITED STATES 4 Institute for the Oceans and Fisheries, University of British Columbia, Vancouver, Canada
AuthorAffiliation_xml	– name: 2 Department of Earth, Ocean and Atmospheric Sciences, University of British Columbia, Vancouver, Canada – name: 1 Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada – name: 3 Department of Botany, University of British Columbia, Vancouver, Canada – name: Pennsylvania State University, UNITED STATES – name: 4 Institute for the Oceans and Fisheries, University of British Columbia, Vancouver, Canada
Author_xml	– sequence: 1 givenname: Christoph M. orcidid: 0000-0002-4459-9372 surname: Deeg fullname: Deeg, Christoph M. – sequence: 2 givenname: Matthias M. surname: Zimmer fullname: Zimmer, Matthias M. – sequence: 3 givenname: Emma E. surname: George fullname: George, Emma E. – sequence: 4 givenname: Filip orcidid: 0000-0002-5381-0125 surname: Husnik fullname: Husnik, Filip – sequence: 5 givenname: Patrick J. surname: Keeling fullname: Keeling, Patrick J. – sequence: 6 givenname: Curtis A. surname: Suttle fullname: Suttle, Curtis A.
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/31150530$$D View this record in MEDLINE/PubMed
BookMark	eNqVU12L1DAULbLi7o7-A9GCLwrOmDRt0_ogLOPXwKLgx3O4TdNOxjbppunsrq_-cW-djuwsiyAtJCTnnNtzeu9pcGSsUUHwmJIFZZy-2tjBGWgWXQd-QQnhGaH3ghOaJGzOGY-PbuyPg9O-3xASU0bTB8ExozQhCSMnwa_l2tl2aLSBrXVwFZaq926QHkz_MoQQxde2Via0Vdhq6exPa7sGzA9vTejX4MPO2a1GFoIvtSntZaiNt3inQmV03YLXMpRgSl2CV2G3vm6GNnyrOmVKZbwG9TC4X0HTq0fTOgu-v3_3bflxfv75w2p5dj6XaUr9vJAlJTlhuFZZnisFPM0pqWKFb0YAskhmaZKyMoqiPEoIgShjBc1kRkkBOZsFT3e6XWN7MeXXiyhKMI6Y5DEiVjtEaWEjOqdbcNfCghZ_DqyrBTj00yjBKCtSwgGrlzGNSEFS4LwoOaMkAp6g1pup2lC0qpTo1UFzIHp4Y_Ra1HYr0AJN0OcseD4JOHsx4G8Rre6lajB9ZYfxuxnLErQ5Qp_dgt7tbkLVgAa0qSzWlaOoOEsyzkmUouYsWNyBwqdU2ADYg5XG8wPCiwMCYry68jUMfS9WX7_8B_bTIfbJzQD_JrdvXgS83gGwLfveqUpI7bHd7JinbgQlYpyUfRZinBQxTQqS41vkvf4_ab8B8zkZrw
CitedBy_id	crossref_primary_10_1016_j_gene_2022_146870 crossref_primary_10_1038_s41559_022_01686_2 crossref_primary_10_1016_j_jece_2024_114675 crossref_primary_10_1111_1462_2920_16307 crossref_primary_10_1128_mra_01123_21 crossref_primary_10_3390_microorganisms10112149 crossref_primary_10_1016_j_watres_2024_122928 crossref_primary_10_1099_ijsem_0_006847 crossref_primary_10_3389_fmicb_2021_624170 crossref_primary_10_1371_journal_pgen_1011218 crossref_primary_10_1099_ijsem_0_004671 crossref_primary_10_1038_s41598_022_20580_2 crossref_primary_10_1128_msystems_00261_25 crossref_primary_10_3390_ani14162415 crossref_primary_10_1038_s43705_023_00223_x crossref_primary_10_1038_s41467_023_39758_x crossref_primary_10_1128_aem_00929_25 crossref_primary_10_1016_j_cbpc_2024_109906 crossref_primary_10_1073_pnas_2025322118 crossref_primary_10_3389_fmicb_2019_02118 crossref_primary_10_1007_s00709_019_01442_7 crossref_primary_10_1128_aem_01575_22 crossref_primary_10_3389_fmicb_2020_01848 crossref_primary_10_3389_frwa_2020_603567 crossref_primary_10_1016_j_scitotenv_2022_161034 crossref_primary_10_1039_D2EW00419D crossref_primary_10_1128_msystems_00966_23 crossref_primary_10_1016_j_cub_2021_05_049 crossref_primary_10_1016_j_envpol_2020_116126 crossref_primary_10_1038_s41564_022_01174_0 crossref_primary_10_3390_microorganisms11030797
Cites_doi	10.1186/s13062-015-0043-z 10.1038/s41564-017-0012-7 10.1093/nar/gkm321 10.1099/ijs.0.64386-0 10.1128/JVI.78.5.2510-2516.2004 10.1038/nmeth.2474 10.1128/AEM.64.2.431-438.1998 10.1128/mBio.02447-17 10.1111/j.1550-7408.2000.tb00060.x 10.1101/gr.1224503 10.1073/pnas.0802042105 10.1371/journal.pcbi.1002195 10.1016/j.jmb.2004.03.016 10.1186/1471-2105-11-538 10.7554/eLife.33014 10.1093/nar/27.23.4636 10.3354/ame035263 10.1073/pnas.1219809110 10.1371/journal.ppat.1000261 10.1186/1471-2105-11-119 10.1093/nar/gkh340 10.1038/s41467-018-07641-9 10.3354/ame027137 10.1016/j.virol.2018.03.010 10.1111/1758-2229.12343 10.1038/nature10335 10.1093/bioinformatics/btu033 10.1128/AEM.57.3.721-726.1991 10.1016/j.tim.2009.11.004 10.1038/s41467-018-03923-4 10.1126/science.1081867 10.1038/nature14486 10.1038/ncomms13219 10.1146/annurev.micro.56.012302.160854 10.1371/journal.pone.0009490 10.1007/BF02012838 10.1111/mec.13812 10.1007/BF01574689 10.1111/j.1462-2920.2005.00743.x 10.1038/ncomms9884 10.1093/molbev/msv281 10.1126/science.1158160 10.1126/science.1101485 10.1093/bib/bbp043 10.1038/sdata.2017.203
ContentType	Journal Article
Copyright	COPYRIGHT 2019 Public Library of Science 2019 Deeg et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2019 Deeg et al 2019 Deeg et al
Copyright_xml	– notice: COPYRIGHT 2019 Public Library of Science – notice: 2019 Deeg et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2019 Deeg et al 2019 Deeg et al
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM ISN ISR 3V. 7QL 7U9 7X7 7XB 88E 8FE 8FH 8FI 8FJ 8FK ABUWG AEUYN AFKRA AZQEC BBNVY BENPR BHPHI C1K CCPQU DWQXO FYUFA GHDGH GNUQQ H94 HCIFZ K9. LK8 M0S M1P M7P PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS 7X8 5PM DOA
DOI	10.1371/journal.ppat.1007801
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Gale In Context: Canada Gale In Context: Science ProQuest Central (Corporate) Bacteriology Abstracts (Microbiology B) Virology and AIDS Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest One Sustainability (subscription) ProQuest Central UK/Ireland ProQuest Central Essentials - QC Biological Science Collection ProQuest Central Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences ProQuest Health & Medical Collection Medical Database Biological Science Database ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest Central ProQuest One Applied & Life Sciences ProQuest One Sustainability ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Health & Medical Research Collection Biological Science Collection AIDS and Cancer Research Abstracts ProQuest Central (New) ProQuest Medical Library (Alumni) Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic MEDLINE Publicly Available Content Database
Database_xml	– sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Biology
DocumentTitleAlternate	Chromulinavorax destructans, a novel pathogen in the candidate phylum Dependentiae
EISSN	1553-7374
ExternalDocumentID	2251154094 oai_doaj_org_article_313b607a4efd4120b06a77bd73102a75 PMC6561590 A587702622 31150530 10_1371_journal_ppat_1007801
Genre	Research Support, Non-U.S. Gov't Journal Article
GeographicLocations	Canada
GeographicLocations_xml	– name: Canada
GrantInformation_xml	– fundername: ; – fundername: ; grantid: 25412 – fundername: ; grantid: 05896 – fundername: ; grantid: ALTF 1260-2016
GroupedDBID	--- 123 29O 2WC 53G 5VS 7X7 88E 8FE 8FH 8FI 8FJ AAFWJ AAUCC AAWOE AAYXX ABDBF ABUWG ACCTH ACGFO ACIHN ACPRK ACUHS ADBBV AEAQA AENEX AEUYN AFFHD AFKRA AFPKN AFRAH AHMBA ALMA_UNASSIGNED_HOLDINGS AOIJS B0M BAIFH BAWUL BBNVY BBTPI BCNDV BENPR BHPHI BPHCQ BVXVI BWKFM CCPQU CITATION CS3 DIK DU5 E3Z EAP EAS EBD EMK EMOBN ESX F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HMCUK HYE IAO IHR INH INR ISN ISR ITC KQ8 LK8 M1P M48 M7P MM. O5R O5S OK1 OVT P2P PGMZT PHGZM PHGZT PIMPY PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO PV9 QF4 QN7 RNS RPM RZL SV3 TR2 TUS UKHRP WOW ~8M 3V. ADRAZ CGR CUY CVF ECM EIF H13 IPNFZ M~E NPM RIG WOQ 7QL 7U9 7XB 8FK AZQEC C1K DWQXO GNUQQ H94 K9. PKEHL PQEST PQUKI PRINS 7X8 PUEGO 5PM AAPBV ABPTK
ID	FETCH-LOGICAL-c661t-bcd10903bcdf899eea76910f4ef4e80aa82c86563d22292500a283b18c810ba93
IEDL.DBID	DOA
ISICitedReferencesCount	31
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000471180400039&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	1553-7374 1553-7366
IngestDate	Sun Oct 01 00:11:15 EDT 2023 Fri Oct 03 12:34:14 EDT 2025 Tue Nov 04 01:42:46 EST 2025 Thu Oct 02 11:38:19 EDT 2025 Sat Nov 29 15:07:15 EST 2025 Tue Nov 11 10:41:19 EST 2025 Tue Nov 04 18:00:17 EST 2025 Thu Nov 13 15:13:04 EST 2025 Thu Nov 13 15:44:04 EST 2025 Wed Feb 19 02:31:00 EST 2025 Tue Nov 18 21:08:09 EST 2025 Sat Nov 29 05:58:52 EST 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	5
Language	English
License	This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Creative Commons Attribution License
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c661t-bcd10903bcdf899eea76910f4ef4e80aa82c86563d22292500a283b18c810ba93
Notes	new_version ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 The authors have declared that no competing interests exist.
ORCID	0000-0002-5381-0125 0000-0002-4459-9372
OpenAccessLink	https://doaj.org/article/313b607a4efd4120b06a77bd73102a75
PMID	31150530
PQID	2251154094
PQPubID	1436335
ParticipantIDs	plos_journals_2251154094 doaj_primary_oai_doaj_org_article_313b607a4efd4120b06a77bd73102a75 pubmedcentral_primary_oai_pubmedcentral_nih_gov_6561590 proquest_miscellaneous_2233855000 proquest_journals_2251154094 gale_infotracmisc_A587702622 gale_infotracacademiconefile_A587702622 gale_incontextgauss_ISR_A587702622 gale_incontextgauss_ISN_A587702622 pubmed_primary_31150530 crossref_citationtrail_10_1371_journal_ppat_1007801 crossref_primary_10_1371_journal_ppat_1007801
PublicationCentury	2000
PublicationDate	2019-05-01
PublicationDateYYYYMMDD	2019-05-01
PublicationDate_xml	– month: 05 year: 2019 text: 2019-05-01 day: 01
PublicationDecade	2010
PublicationPlace	United States
PublicationPlace_xml	– name: United States – name: San Francisco – name: San Francisco, CA USA
PublicationTitle	PLoS pathogens
PublicationTitleAlternate	PLoS Pathog
PublicationYear	2019
Publisher	Public Library of Science Public Library of Science (PLoS)
Publisher_xml	– name: Public Library of Science – name: Public Library of Science (PLoS)
References	A Andersson (ref13) 1989; 17 S Mukherjee (ref18) 2011; 477 D Sassera (ref24) 2006; 56 V Delafont (ref4) 2015; 7 X Pan (ref20) 2008; 320 MN Price (ref47) 2010; 5 J Gonzalez (ref10) 1993; 94 S Al-Khodor (ref17) 2010; 18 CT Brown (ref8) 2015; 523 R Andersen (ref34) 2005 K Anantharaman (ref7) 2016; 7 SR Eddy (ref48) 2011; 7 YK Yeoh (ref3) 2015; 33 D Hyatt (ref46) 2010; 11 CA Suttle (ref33) 1991; 57 PD Karp (ref40) 2009; 11 FA Matsen (ref44) 2010; 11 P Dean (ref26) 2018; 9 S Sonnberg (ref29) 2008; 105 L Li (ref43) 2003; 13 AL Delcher (ref37) 1999; 27 H Rheims (ref1) 1996; 17 C-S Chin (ref36) 2013; 10 D Reynolds (ref31) 2016; 25 A Stamatakis (ref42) 2014; 30 JM Rose (ref35) 2004; 34 RC Edgar (ref41) 2004; 32 CM Deeg (ref16) 2018; 7 L Käll (ref38) 2004; 338 D Tashyreva (ref23) 2018; 9 MG Weinbauer (ref11) 1998; 64 JS McLean (ref2) 2013; 110 C Lambert (ref30) 2015; 6 DH Parks (ref6) 2017; 2 B La Scola (ref28) 2003; 299 D Raoult (ref15) 2004; 306 I Pagnier (ref5) 2015; 10 C Matz (ref12) 2002; 27 C Camus-Bouclainville (ref19) 2004; 78 PJ Keeling (ref25) 2002; 56 DH Parks (ref22) 2018 CR Schvarcz (ref32) 2018; 518 J Boenigk (ref14) 2005; 7 J Boenigk (ref9) 2000; 47 BJ Tully (ref21) 2018; 5 C Jain (ref45) 2018; 9 DE Akiyoshi (ref27) 2009; 5 Y Moriya (ref39) 2007; 35
References_xml	– volume: 10 start-page: 13 issue: 1 year: 2015 ident: ref5 article-title: Babela massiliensis, a representative of a widespread bacterial phylum with unusual adaptations to parasitism in amoebae publication-title: Biology direct doi: 10.1186/s13062-015-0043-z – volume: 2 start-page: 1533 issue: 11 year: 2017 ident: ref6 article-title: Recovery of nearly 8,000 metagenome-assembled genomes substantially expands the tree of life publication-title: Nature microbiology doi: 10.1038/s41564-017-0012-7 – volume: 35 start-page: W182 issue: suppl_2 year: 2007 ident: ref39 article-title: KAAS: an automatic genome annotation and pathway reconstruction server publication-title: Nucleic acids research doi: 10.1093/nar/gkm321 – volume: 56 start-page: 2535 issue: 11 year: 2006 ident: ref24 article-title: ‘Candidatus Midichloria mitochondrii’, an endosymbiont of the tick Ixodes ricinus with a unique intramitochondrial lifestyle publication-title: International journal of systematic and evolutionary microbiology doi: 10.1099/ijs.0.64386-0 – volume: 78 start-page: 2510 issue: 5 year: 2004 ident: ref19 article-title: A virulence factor of myxoma virus colocalizes with NF-κB in the nucleus and interferes with inflammation publication-title: Journal of virology doi: 10.1128/JVI.78.5.2510-2516.2004 – volume: 94 issue: 1 year: 1993 ident: ref10 article-title: Grazing by marine nanoflagellates on viruses and virus-sized particles: ingestion and digestion publication-title: Marine Ecology Progress Series MESEDT – volume: 10 start-page: 563 issue: 6 year: 2013 ident: ref36 article-title: Nonhybrid, finished microbial genome assemblies from long-read SMRT sequencing data publication-title: Nature methods doi: 10.1038/nmeth.2474 – volume: 64 start-page: 431 issue: 2 year: 1998 ident: ref11 article-title: Significance of viral lysis and flagellate grazing as factors controlling bacterioplankton production in a eutrophic lake publication-title: Applied and Environmental Microbiology doi: 10.1128/AEM.64.2.431-438.1998 – volume: 9 start-page: e02447 issue: 2 year: 2018 ident: ref23 article-title: Life Cycle, Ultrastructure, and Phylogeny of New Diplonemids and Their Endosymbiotic Bacteria publication-title: mBio doi: 10.1128/mBio.02447-17 – volume: 47 start-page: 350 issue: 4 year: 2000 ident: ref9 article-title: Particle Handling during Interception Feeding by Four Species of Heterotrophic Nanoflagellates publication-title: Journal of Eukaryotic Microbiology doi: 10.1111/j.1550-7408.2000.tb00060.x – volume: 13 start-page: 2178 issue: 9 year: 2003 ident: ref43 article-title: OrthoMCL: identification of ortholog groups for eukaryotic genomes publication-title: Genome research doi: 10.1101/gr.1224503 – start-page: 429 year: 2005 ident: ref34 article-title: Recipes for freshwater and seawater media publication-title: Algal culturing techniques Elsevier, Amsterdam – volume: 105 start-page: 10955 issue: 31 year: 2008 ident: ref29 article-title: Poxvirus ankyrin repeat proteins are a unique class of F-box proteins that associate with cellular SCF1 ubiquitin ligase complexes publication-title: Proceedings of the National Academy of Sciences doi: 10.1073/pnas.0802042105 – volume: 7 start-page: e1002195 issue: 10 year: 2011 ident: ref48 article-title: Accelerated profile HMM searches publication-title: PLoS computational biology doi: 10.1371/journal.pcbi.1002195 – volume: 338 start-page: 1027 issue: 5 year: 2004 ident: ref38 article-title: A combined transmembrane topology and signal peptide prediction method publication-title: Journal of molecular biology doi: 10.1016/j.jmb.2004.03.016 – volume: 11 start-page: 538 issue: 1 year: 2010 ident: ref44 article-title: pplacer: linear time maximum-likelihood and Bayesian phylogenetic placement of sequences onto a fixed reference tree publication-title: BMC bioinformatics doi: 10.1186/1471-2105-11-538 – volume: 7 start-page: e33014 year: 2018 ident: ref16 article-title: The kinetoplastid-infecting Bodo saltans virus (BsV), a window into the most abundant giant viruses in the sea publication-title: eLife doi: 10.7554/eLife.33014 – volume: 27 start-page: 4636 issue: 23 year: 1999 ident: ref37 article-title: Improved microbial gene identification with GLIMMER publication-title: Nucleic acids research doi: 10.1093/nar/27.23.4636 – volume: 34 start-page: 263 issue: 3 year: 2004 ident: ref35 article-title: Counting heterotrophic nanoplanktonic protists in cultures and aquatic communities by flow cytometry publication-title: Aquatic microbial ecology doi: 10.3354/ame035263 – volume: 110 start-page: E2390 issue: 26 year: 2013 ident: ref2 article-title: Candidate phylum TM6 genome recovered from a hospital sink biofilm provides genomic insights into this uncultivated phylum publication-title: Proceedings of the National Academy of Sciences doi: 10.1073/pnas.1219809110 – volume: 5 start-page: e1000261 issue: 1 year: 2009 ident: ref27 article-title: Genomic survey of the non-cultivatable opportunistic human pathogen, Enterocytozoon bieneusi publication-title: PLoS pathogens doi: 10.1371/journal.ppat.1000261 – volume: 11 start-page: 119 issue: 1 year: 2010 ident: ref46 article-title: Prodigal: prokaryotic gene recognition and translation initiation site identification publication-title: BMC bioinformatics doi: 10.1186/1471-2105-11-119 – volume: 32 start-page: 1792 issue: 5 year: 2004 ident: ref41 article-title: MUSCLE: multiple sequence alignment with high accuracy and high throughput publication-title: Nucleic acids research doi: 10.1093/nar/gkh340 – volume: 9 start-page: 5114 issue: 1 year: 2018 ident: ref45 article-title: High throughput ANI analysis of 90K prokaryotic genomes reveals clear species boundaries publication-title: Nature communications doi: 10.1038/s41467-018-07641-9 – volume: 27 start-page: 137 issue: 2 year: 2002 ident: ref12 article-title: Role of bacterial phenotypic traits in selective feeding of the heterotrophic nanoflagellate Spumella sp publication-title: Aquatic microbial ecology doi: 10.3354/ame027137 – volume: 518 start-page: 423 year: 2018 ident: ref32 article-title: A giant virus infecting green algae encodes key fermentation genes publication-title: Virology doi: 10.1016/j.virol.2018.03.010 – volume: 7 start-page: 970 issue: 6 year: 2015 ident: ref4 article-title: Shedding light on microbial dark matter: a TM6 bacterium as natural endosymbiont of a free‐living amoeba publication-title: Environmental microbiology reports doi: 10.1111/1758-2229.12343 – volume: 477 start-page: 103 issue: 7362 year: 2011 ident: ref18 article-title: Modulation of Rab GTPase function by a protein phosphocholine transferase publication-title: Nature doi: 10.1038/nature10335 – volume: 30 start-page: 1312 issue: 9 year: 2014 ident: ref42 article-title: RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies publication-title: Bioinformatics doi: 10.1093/bioinformatics/btu033 – volume: 57 start-page: 721 issue: 3 year: 1991 ident: ref33 article-title: Use of ultrafiltration to isolate viruses from seawater which are pathogens of marine phytoplankton publication-title: Applied and environmental microbiology doi: 10.1128/AEM.57.3.721-726.1991 – volume: 18 start-page: 132 issue: 3 year: 2010 ident: ref17 article-title: Functional diversity of ankyrin repeats in microbial proteins publication-title: Trends in microbiology doi: 10.1016/j.tim.2009.11.004 – volume: 9 year: 2018 ident: ref26 article-title: Transporter gene acquisition and innovation in the evolution of Microsporidia intracellular parasites publication-title: Nature communications doi: 10.1038/s41467-018-03923-4 – volume: 299 start-page: 2033 year: 2003 ident: ref28 article-title: A Giant Virus in Amoebae publication-title: Science doi: 10.1126/science.1081867 – volume: 523 start-page: 208 issue: 7559 year: 2015 ident: ref8 article-title: Unusual biology across a group comprising more than 15% of domain Bacteria publication-title: Nature doi: 10.1038/nature14486 – volume: 7 start-page: 13219 year: 2016 ident: ref7 article-title: Thousands of microbial genomes shed light on interconnected biogeochemical processes in an aquifer system publication-title: Nature communications doi: 10.1038/ncomms13219 – volume: 56 start-page: 93 issue: 1 year: 2002 ident: ref25 article-title: Microsporidia: biology and evolution of highly reduced intracellular parasites publication-title: Annual Reviews in Microbiology doi: 10.1146/annurev.micro.56.012302.160854 – volume: 5 start-page: e9490 issue: 3 year: 2010 ident: ref47 article-title: FastTree 2–approximately maximum-likelihood trees for large alignments publication-title: PloS one doi: 10.1371/journal.pone.0009490 – volume: 17 start-page: 251 issue: 3 year: 1989 ident: ref13 article-title: Nutritional characteristics of a mixotrophic nanoflagellate, Ochromonas sp. publication-title: Microbial Ecology doi: 10.1007/BF02012838 – volume: 25 start-page: 5242 issue: 20 year: 2016 ident: ref31 article-title: Evolution and function of eukaryotic‐like proteins from sponge symbionts publication-title: Molecular ecology doi: 10.1111/mec.13812 – volume: 17 start-page: 159 issue: 3–4 year: 1996 ident: ref1 article-title: A molecular approach to search for diversity among bacteria in the environment publication-title: Journal of industrial microbiology doi: 10.1007/BF01574689 – volume: 7 start-page: 685 issue: 5 year: 2005 ident: ref14 article-title: High diversity of the ‘Spumella‐like’flagellates: an investigation based on the SSU rRNA gene sequences of isolates from habitats located in six different geographic regions publication-title: Environmental microbiology doi: 10.1111/j.1462-2920.2005.00743.x – volume: 6 start-page: 8884 year: 2015 ident: ref30 article-title: Ankyrin-mediated self-protection during cell invasion by the bacterial predator Bdellovibrio bacteriovorus publication-title: Nature communications doi: 10.1038/ncomms9884 – volume: 33 start-page: 915 issue: 4 year: 2015 ident: ref3 article-title: Comparative genomics of candidate phylum TM6 suggests that parasitism is widespread and ancestral in this lineage publication-title: Molecular biology and evolution doi: 10.1093/molbev/msv281 – volume: 320 start-page: 1651 issue: 5883 year: 2008 ident: ref20 article-title: Ankyrin repeat proteins comprise a diverse family of bacterial type IV effectors publication-title: Science doi: 10.1126/science.1158160 – volume: 306 start-page: 1344 issue: 5700 year: 2004 ident: ref15 article-title: The 1.2-megabase genome sequence of Mimivirus publication-title: Science doi: 10.1126/science.1101485 – year: 2018 ident: ref22 article-title: A standardized bacterial taxonomy based on genome phylogeny substantially revises the tree of life publication-title: Nature biotechnology – volume: 11 start-page: 40 issue: 1 year: 2009 ident: ref40 article-title: Pathway Tools version 13.0: integrated software for pathway/genome informatics and systems biology publication-title: Briefings in bioinformatics doi: 10.1093/bib/bbp043 – volume: 5 start-page: 170203 year: 2018 ident: ref21 article-title: The reconstruction of 2,631 draft metagenome-assembled genomes from the global oceans publication-title: Scientific data doi: 10.1038/sdata.2017.203
SSID	ssj0041316
Score	2.4336216
Snippet	Members of the major candidate phylum Dependentiae (a.k.a. TM6) are widespread across diverse environments from showerheads to peat bogs; yet, with the...
SourceID	plos doaj pubmedcentral proquest gale pubmed crossref
SourceType	Open Website Open Access Repository Aggregation Database Index Database Enrichment Source
StartPage	e1007801
SubjectTerms	Amoeba Animals Ankyrins Atmospheric sciences Bacteria Bacteria - classification Bacteria - genetics Bacteria - pathogenicity Bioinformatics Biological evolution Biology Biology and Life Sciences Bogs Chrysophyta - microbiology Computer and Information Sciences Dependence Flagellates Flow cytometry Genes Genetic aspects Genome, Bacterial Genomes Host Microbial Interactions Host-bacteria relationships Immunology Infections Integrated software Metabolic pathways Microscopy Nutrients Parasites Parasitism Pathogens Peat Peat bogs Phylogenetics Phylogeny Physiological aspects Proteins Research and Analysis Methods Secretion Supervision Viruses Zooplankton Zooplankton - microbiology
SummonAdditionalLinks	– databaseName: Biological Science Database dbid: M7P link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9MwELeggMQL37DCQAYh8UI2J27j9AmNjwkkVE18aW_RxXa6imKHJduAZ_5w7hKnEDTgAalqpdyliu3z3c_O-XeMPdSmLLUycRRb_MKID1GBYT7KJkWiDcyS7lTah9dqPs_292d7YcOtDmmVvU9sHbXxmvbItxPCwlNajTypPkdUNYreroYSGmfZOWJJkG3q3l7vidE_t6VPqTROpGSahqNzUsXbYaS2qgqaNlMgC2Vh-tDUMviv_fSoWvn6NBD6ey7lL8Fp9_L_NusKuxRgKd_p7OgqO2PdNXahK1T59Tr7Thy6lEjl4Bht5gs3tiOexUDHH3PgVNjYoy1yX_JPlOP3zftqBe4jQkveHEDDw5G_GpVPls74E750jUeZ5dYtFy1zLNd0yIb2IDiOPrpN_jzU6EU_ZG-w97sv3j17GYX6DZHGqN9EhTaU9inxt8RlnbWgUkQn5cTiJxMAWaIzxJPSUFFxxGICEOwUcaazWBQwkzfZyHlnNxhHWKlnUOJVvJ0o50CAgdSqqSm0kNMxk_3Q5TqQm1ONjVXevrFTuMjpOjKnAc_DgI9ZtL6r6sg9_qH_lKxirUvU3O0Ff7jIw0zPZSyLVCjAVppJnIhCpKBUYRQC6QQUPuoDsqmcyDccZfcs4Kiu81dv5_nONFMKF8VJ8kelNwOlR0Gp9NhYDeFEBXYZkXoNNDcHmuhC9EC8Qfbdt7nOf1ol3tnb7eni-2sx_Sll7Dnrj0hHSiLLE2LMbnVTZN1vxPCEzh8lajB5Bh07lLjlQct9juaCAFzc_vtj3WEXEdjOusTUTTbCGWHvsvP6uFnWh_daJ_EDkfVyXQ priority: 102 providerName: ProQuest – databaseName: Public Library of Science (PLoS) Journals Open Access dbid: FPL link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3db9MwELdQAYkXvmGFDRmExAsBJ27j9HEwKpCmauJLe4sujrNVlKQi2QY884fzu8QtZFqFkKpWyp0j-3y-j_r8sxBPbV4U1uRhEDp8weNTkMHNB8koi2xOk6g7lfZ538xmyeHh5OBPonhuB1-b8KWX6Yvlkpp2Tz_h41qXIx3HXMI1PdhfWV7Y4zD2x-M2tey5nxalf22LB8tFVV8UaJ6vl_zLAU1v_G_Xb4rrPtSUu51u3BKXXHlbXO0un_xxR_xiXFwujirpFHrwXeauA5OF85LPJUm-rLiCfsmqkF-5bu9nVS0XVH5BuCibY2qkP8ZXg_kMuX11JudlU4HmpCvnRy0arLR8cIb_V5CYUZhCuefv3YVtcXfFp-mbj6_fBv5OhsDCkzdBZnMu5dT4LZCqOUcmRsRRjBw-iSJKIpsgRtQ5XxSO-EoRApgsTGwSqowm-p4YlFXptoREqGgnVOApmjOMHCnKKXZmnGdW6fFQ6NVUpdYDlvO9GYu03YUzSFw6QaYs39TLdyiCdatlB9jxD_5XrAVrXobbbh9gIlO_elMd6ixWhjDKfBRGKlMxGZPlBsFxRAZdfcI6lDKgRskVO0d0Utfpuw-zdHecGINEN4o2Mr3vMT3zTEWFwVrypyQgMgbq6nFu9zhhFmyPvMX6vBpznUacTI45nUfLlY5fTH68JvNLuQqvdNUJ82jNAHhKDcX9bkms5caoTTDooJjeYukJtk8p58ctnjnUBUG1erC5xw_FNQSqk67QdFsMsBrcjrhiT5t5_e1RawR-AzWsXtc priority: 102 providerName: Public Library of Science
Title	Chromulinavorax destructans, a pathogen of microzooplankton that provides a window into the enigmatic candidate phylum Dependentiae
URI	https://www.ncbi.nlm.nih.gov/pubmed/31150530 https://www.proquest.com/docview/2251154094 https://www.proquest.com/docview/2233855000 https://pubmed.ncbi.nlm.nih.gov/PMC6561590 https://doaj.org/article/313b607a4efd4120b06a77bd73102a75 http://dx.doi.org/10.1371/journal.ppat.1007801
Volume	15
WOSCitedRecordID	wos000471180400039&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1553-7374 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0041316 issn: 1553-7374 databaseCode: DOA dateStart: 20050101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVPQU databaseName: Biological Science Database (ProQuest) customDbUrl: eissn: 1553-7374 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0041316 issn: 1553-7374 databaseCode: M7P dateStart: 20050901 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection (ProQuest) customDbUrl: eissn: 1553-7374 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0041316 issn: 1553-7374 databaseCode: 7X7 dateStart: 20050901 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1553-7374 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0041316 issn: 1553-7374 databaseCode: BENPR dateStart: 20050901 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 1553-7374 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0041316 issn: 1553-7374 databaseCode: PIMPY dateStart: 20050901 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVATS databaseName: Public Library of Science (PLoS) Journals Open Access customDbUrl: eissn: 1553-7374 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0041316 issn: 1553-7374 databaseCode: FPL dateStart: 20050101 isFulltext: true titleUrlDefault: http://www.plos.org/publications/ providerName: Public Library of Science
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3db9MwELeggMQLGl9bYVQGIfFCmBO3cfq4wSomjSoaHypP0cVxtoqSVCTbgNf949zFTrSgob3w4kq5cyXfXe6jPf-OsZc6y3OtMt_zDS4Y8cFLMcx70TgNdAbTwN5K-3Ko5vNosZjGl0Z9UU-YhQe2gtuRvkxDoWBs8mzsByIVISiVZgrzkgBUg16KWU9bTFkfjJ65GXpKQ3E8JcPQXZqTyt9xOnqzXkPd9AhEbiBMG5Qa7P7OQw_Wq7K6Kv38u4vyUliabbB7Lp_ku_Yc99kNUzxgd-yEyV8P2QWB31IHVAFnqOyfPDMWMRYj1GsOnAYSl2hDvMz5d-rN-12W6xUU3zAl5PUJ1Nxd1auQ-Rzr9_KcL4u6RJrhplgeN4ivXNPlGPrtgKPW0N3xd262LvoP84h9nu1_evvec3MXPI3RuvZSnVG7psTPHMsxY0CFmFXkqIKxiQRAFOgI80CZ0TBwzKEEYJKS-pGOfJHCVD5mg6IszBbjmA7qKeT4FLcTVBwIyCA0apKlWsjJkMlW8Il2oOQ0G2OVNP-0KSxOrBwTUlfi1DVkXrdrbUE5ruHfI512vASp3TxAQ0ucoSXXGdqQvSCLSAg0o6CunGM4rark4OM82Z1ESmExGwT_ZDrqMb1yTHmJh9XgbkKgyAiMq8e53ePEV1_3yFtkne2ZqySggnFCJTvubC32avLzjkxfSp12hSlPiUdKArkTYsg2rYF3ciNkJnTaSFE90-8Jtk8plicNZjmaCybO4sn_0MRTdhfT1qltO91mA3xtzDN2W5_Vy-rHiN1UC9Ws0Yjd2tufx0ejxjngOosPR9TdGyMlPvgQf_0DgitqdQ
linkProvider	Directory of Open Access Journals
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9NAEF5VKQguvKGBAgsCccF0bSde54BQoVSNmkYRtKiczHp3nUYEr6ndhnLm9_AbmbHXBqMCpx6QokTyji3vZJ72zDeEPJIqSSRXruNq-AKPL5wY3LwT9mJPKjHwqq60dyM-Hof7-4PJEvle98JgWWVtE0tDrYzEZ-RrHsbCfcxGXmSfHZwahW9X6xEalVhs65MFpGz58-EG_L-PPW_z9e6rLcdOFXAk-KLCiaXCYkQffhNINrQWPACfmfQ0fEImROjJEKIcX-Goa4gQmAAXHLuhDF0WCwRfApO_3ANhDztkeTLcmbyvbT94hHLYKg7jcbgfBLZZz-fumpWNZ1kmirI2IbSDaGpnWM4MaDxDJ5ub_LSw9_fqzV_c4ebl_42RV8glG3jT9UpTrpIlnV4j56tRnCfXyTdECcZSsVQcg1Z8oUpX0LrgyulTKiiObjagbdQk9BNWMX41JpuL9CMEz7Q4EAW1TY05EC9mqTILOksLA2ua6nQ2LbFxqcQ2InzKQkG-wTHQDTuFGCytvkH2zoQFN0knNaleIRQCZzkQCRyF0xFUTzChRKB5X8WS-f0u8WtRiaSFb8cpIvOofCfJIY2rGBmhgEVWwLrEac7KKviSf9C_RClsaBF8vDxgDqeRtWWR7_pxwLiAXaqe67GYBYLzWHFIFTzB4VYfogxHCC-SYv3SVBzleTR8O47W-yHnkPZ73h-J3rSInliixMBmpbA9I8AyhC1rUa62KMFIytbyCupTvec8-qkFcGatJ6cvP2iW8aJYk5hqc4Q0vo9wgIx1ya1KJRu-IYYVuDdY4S1lbTG2vZLODkp0dxAXSDHY7b_f1n1yYWt3ZxSNhuPtO-QihPGDqgx3lXRAO_Rdck4eF7P88J41UZR8OGtl_gFxN8_W
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3db9MwELem8iFe-IYVBhgE4oVQJ2nj9AGhQamYNlUVH9PegmM7XUWxw5KtjGf-Kv467hKnEDTgaQ9IVSvFlyh27-53Tu5-R8hDqbJMcuV7voYvQHzhpQDzXtxPA6nEMKir0nZ3-GQS7-0Np2vke1MLg2mVjU-sHLWyEp-R9wKMhQe4G-llLi1iOho_zz972EEK37Q27TRqFdnWx0vYvhXPtkbwXz8KgvGrdy9fe67DgCcBl0ovlQoTE0P4zWDjobXgEeBn1tfwiZkQcSBjiHhChW2vIVpgAuA49WMZ-ywVSMQE7v8MR9LyKm1w2qAAYEPVdhXb8ng8jCJXthdyv-e05Gmei7LKUohdS5oGFqvuASuM6OQLW5wUAP-ex_kLMI4v_c9LeplcdOE43azt5wpZ0-YqOVc36Dy-Rr4hdzAmkBlxBLbyhSpdE-4CwNMnVFBs6GzBBqnN6CfMbfxqbb4Q5iOE1LTcFyV1pY4FCC_nRtklnZvSwpim2sxnFWMulVhchM9eKGg9wAUdud7E4H_1dfL-VJbgBukYa_Q6oRBOy6HI4CicjlR7ggklIs0HKpUsHHRJ2KhNIh2pO_YWWSTVm0oOm7t6IRNUtsQpW5d4q7PymtTkH_IvUCNXskhJXh2wB7PEebgk9MM0YlzALFXfD1jKIsF5qjhsIALB4VYfoD4nSDpiUNdm4rAokq23k2RzEHPOgigI_ij0piX02AllFiYrhaskgSVDMrOW5EZLElynbA2vo201cy6SnxYBZzY2c_Lw_dUwXhQzFY22hygThkgSyFiX3KzNc7VuyGwFoAcjvGW4rYVtj5j5fsX5DuoCGw926--3dY-cBwtOdrYm27fJBYjth3Vu7gbpgHHoO-SsPCrnxcHdyldR8uG0LfkHz-bXFQ
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Chromulinavorax+destructans%2C+a+pathogen+of+microzooplankton+that+provides+a+window+into+the+enigmatic+candidate+phylum+Dependentiae&rft.jtitle=PLoS+pathogens&rft.au=Christoph+M+Deeg&rft.au=Matthias+M+Zimmer&rft.au=Emma+E+George&rft.au=Filip+Husnik&rft.date=2019-05-01&rft.pub=Public+Library+of+Science+%28PLoS%29&rft.issn=1553-7366&rft.eissn=1553-7374&rft.volume=15&rft.issue=5&rft.spage=e1007801&rft_id=info:doi/10.1371%2Fjournal.ppat.1007801&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_313b607a4efd4120b06a77bd73102a75
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1553-7374&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1553-7374&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1553-7374&client=summon