Heritable tumor cell division rate heterogeneity induces clonal dominance

Tumors consist of a hierarchical population of cells that differ in their phenotype and genotype. This hierarchical organization of cells means that a few clones (i.e., cells and several generations of offspring) are abundant while most are rare, which is called clonal dominance. Such dominance also...

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Bibliographic Details
Published in:	PLoS computational biology Vol. 14; no. 2; p. e1005954
Main Authors:	Palm, Margriet M., Elemans, Marjet, Beltman, Joost B.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.02.2018 Public Library of Science (PLoS)
Subjects:	Autosomal dominant inheritance Bar codes Bioinformatics Biology and Life Sciences Cancer Cell division Cell self-renewal Computer applications Computer simulation Dominance Epigenetics Experiments Gene expression Genetic aspects Genotypes Health aspects Heterogeneity Labeling Medicine and Health Sciences Mutation Offspring Phenotypes Physiological aspects R&D Research & development Research and Analysis Methods Software Stem cells Tumor cells Tumors Netherlands
ISSN:	1553-7358, 1553-734X, 1553-7358
Online Access:	Get full text
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