Reconstruction of the cell entry pathway of an extinct virus

Endogenous retroviruses (ERVs), remnants of ancient germline infections, comprise 8% of the human genome. The most recently integrated includes human ERV-K (HERV-K) where several envelope (env) sequences remain intact. Viral pseudotypes decorated with one of those Envs are infectious. Using a recomb...

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Veröffentlicht in:	PLoS pathogens Jg. 14; H. 8; S. e1007123
Hauptverfasser:	Robinson-McCarthy, Lindsey R., McCarthy, Kevin R., Raaben, Matthijs, Piccinotti, Silvia, Nieuwenhuis, Joppe, Stubbs, Sarah H., Bakkers, Mark J. G., Whelan, Sean P. J.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 01.08.2018 Public Library of Science (PLoS)
Schlagworte:	Acids Anticoagulants Binding sites Biochemistry Biology and life sciences Biosynthesis Cancer Cell surface CRISPR Endangered & extinct species Endogenous retroviruses Endogenous Retroviruses - physiology Extinction Fusion protein Genes Genetic aspects Genetic screening Genomes Glycoproteins Heparan sulfate Heparin Heparitin Sulfate - metabolism History Humans Infections Infectious diseases Leukemia Medical schools Medicine and Health Sciences Mutation Organic chemistry pH effects Physical Sciences Physiological aspects Pretreatment Proteins Research and Analysis Methods Retroviruses RNA polymerase Stem cells Stomatitis Sulfates Viral Envelope Proteins - metabolism Viral Tropism - physiology Virions Virology Virus attachment Virus Internalization Virus replication Viruses United States Netherlands United States > US Massachusetts
ISSN:	1553-7374, 1553-7366, 1553-7374
Online-Zugang:	Volltext
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