Worldwide Emergence of Extensively Drug-resistant Tuberculosis

Mycobacterium tuberculosis strains that are resistant to an increasing number of second-line drugs used to treat multidrug-resistant tuberculosis (MDR TB) are becoming a threat to public health worldwide. We surveyed the Network of Supranational Reference Laboratories for M. tuberculosis isolates th...

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Published in:Emerging infectious diseases Vol. 13; no. 3; pp. 380 - 387
Main Authors: Shah, N. Sarita, Wright, Abigail, Bai, Gill-Han, Barrera, Lucia, Boulahbal, Fadila, Martín-Casabona, Nuria, Drobniewski, Francis, Gilpin, Chris, Havelková, Marta, Lepe, Rosario, Lumb, Richard, Metchock, Beverly, Portaels, Françoise, Rodrigues, Maria Filomena, Rüsch-Gerdes, Sabine, Van Deun, Armand, Vincent, Veronique, Laserson, Kayla, Wells, Charles, Cegielski, J. Peter
Format: Journal Article
Language:English
Published: United States U.S. National Center for Infectious Diseases 01.03.2007
Centers for Disease Control and Prevention
Subjects:
Antitubercular Agents - pharmacology
Communicable Disease Control
Drug resistance in microorganisms
emerging
Global Health
Health aspects
Humans
infectious diseases
Laboratories
multidrug-resistant
Mycobacterium tuberculosis
Mycobacterium tuberculosis - drug effects
Public health
second-line drugs
Sentinel Surveillance
tuberculosis
Tuberculosis - drug therapy
Tuberculosis - microbiology
Tuberculosis - prevention & control
Tuberculosis, Multidrug-Resistant
United States
Switzerland
ISSN:1080-6040, 1080-6059
Online Access:Get full text
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Summary:Mycobacterium tuberculosis strains that are resistant to an increasing number of second-line drugs used to treat multidrug-resistant tuberculosis (MDR TB) are becoming a threat to public health worldwide. We surveyed the Network of Supranational Reference Laboratories for M. tuberculosis isolates that were resistant to second-line anti-TB drugs during 2000-2004. We defined extensively drug-resistant TB (XDR TB) as MDR TB with further resistance to > or = 3 of the 6 classes of second-line drugs. Of 23 eligible laboratories, 14 (61%) contributed data on 17,690 isolates, which reflected drug susceptibility results from 48 countries. Of 3,520 (19.9%) MDR TB isolates, 347 (9.9%) met criteria for XDR TB. Further investigation of population-based trends and expanded efforts to prevent drug resistance and effectively treat patients with MDR TB are crucial for protection of public health and control of TB.
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ISSN:1080-6040
1080-6059
DOI:10.3201/eid1303.061400