Efficacy of mefloquine and its enantiomers in a murine model of Mycobacterium avium infection

The treatment of Mycobacterium avium infections is still long, complex, and often poorly tolerated, besides emergence of resistances. New active molecules that are more effective and better tolerated are deeply needed. Mefloquine and its enantiomers ((+) Erythro-mefloquine ((+)-EMQ) and (-)-Erythro-...

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Bibliographic Details
Published in:	PloS one Vol. 19; no. 9; p. e0311167
Main Authors:	Froment, Antoine, Delomez, Julia, Da Nascimento, Sophie, Dassonville-Klimpt, Alexandra, Andréjak, Claire, Peltier, François, Joseph, Cédric, Sonnet, Pascal, Lanoix, Jean-Philippe
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 30.09.2024
Subjects:	Aerosols Animal experimentation Animal models Animal welfare Animals Antibiotics Antitubercular Agents - chemistry Antitubercular Agents - pharmacology Biology and Life Sciences Care and treatment Clarithromycin Clarithromycin - pharmacology Complications and side effects Diagnosis Disease Models, Animal Drug development Drug efficacy Drug interactions Drug Therapy, Combination Effectiveness Enantiomers Ethambutol Ethambutol - pharmacology Ethanol Evaluation Female Human health and pathology In vivo methods and tests Infections Infectious diseases Life Sciences Lung - drug effects Lung - microbiology Lung - pathology Lungs Medicine and Health Sciences Mefloquine Mefloquine - pharmacology Mice Mice, Inbred BALB C Mycobacterial infections Mycobacterium avium Mycobacterium avium - drug effects Patient outcomes Physical Sciences Research and Analysis Methods Rifampin Rifampin - pharmacology Stereoisomerism Sterilization Tuberculosis - drug therapy Tuberculosis - microbiology France
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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