Toll-like Receptor 9 Promotes Initiation of Gastric Tumorigenesis by Augmenting Inflammation and Cellular Proliferation

Gastric cancer (GC) is strongly linked with chronic gastritis after Helicobacter pylori infection. Toll-like receptors (TLRs) are key innate immune pathogenic sensors that mediate chronic inflammatory and oncogenic responses. Here, we investigated the role of TLR9 in the pathogenesis of GC, includin...

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Published in:	Cellular and Molecular Gastroenterology and Hepatology Vol. 14; no. 3; pp. 567 - 586
Main Authors:	Tang, Ke, McLeod, Louise, Livis, Thaleia, West, Alison C., Dawson, Ruby, Yu, Liang, Balic, Jesse J., Chonwerawong, Michelle, Wray-McCann, Georgie, Oshima, Hiroko, Oshima, Masanobu, Deswaerte, Virginie, Ferrero, Richard L., Jenkins, Brendan J.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.01.2022 Elsevier BV Elsevier
Subjects:	Animals Carcinogenesis Carcinogenesis - pathology Cell Proliferation Cytokine Receptor gp130 Cytokine Receptor gp130 - metabolism Gastric Cancer Gastric Mucosa Gastric Mucosa - pathology Gastritis Gastritis - pathology Gastroenterology and Hepatology H pylori Helicobacter Infections Helicobacter Infections - metabolism Helicobacter pylori Helicobacter pylori - metabolism Humans Hyperplasia Hyperplasia - pathology Inflammation Inflammation - pathology Initiation Ligands Mice NF-kappa B NF-kappa B - metabolism Original Research Stomach Neoplasms Stomach Neoplasms - pathology TLR9 Toll-Like Receptor 9 Toll-Like Receptor 9 - genetics Toll-Like Receptor 9 - metabolism PCNA MAPK H pylori TME TCGA NF-κB PI3K ANOVA Gastric Cancer TLR9 qPCR TLR GC Initiation WT ERK nuclear factor kappa B mitogen-activated protein kinase analysis of variance extracellular signal-related kinase quantitative polymerase chain reaction The Cancer Genome Atlas proliferating cell nuclear antigen toll-like receptor phosphatidylinositol-3′-kinase tumor microenvironment wild-type
ISSN:	2352-345X, 2352-345X
Online Access:	Get full text
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