Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis

We report the experiences of 5 patients taking bedaquiline with delamanid in combination: 1 patient was cured; 3 culture converted, with 2 continuing and 1 changing therapy; and 1 died from respiratory insufficiency. For 2 patients, QT-interval prolongation but no arrhythmias occurred. Use of this t...

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Bibliographic Details
Published in:Emerging infectious diseases Vol. 23; no. 10; pp. 1718 - 1721
Main Authors: Maryandyshev, Andrey, Pontali, Emanuele, Tiberi, Simon, Akkerman, Onno, Ganatra, Shashank, Sadutshang, Tsetan Dorji, Alffenaar, Jan-Willem, Amale, Rohit, Mullerpattan, Jai, Topgyal, Sonam, Udwadia, Zarir Farokh, Centis, Rosella, D’Ambrosio, Lia, Sotgiu, Giovanni, Migliori, Giovanni Battista
Format: Journal Article
Language:English
Published: United States U.S. National Center for Infectious Diseases 01.10.2017
Centers for Disease Control and Prevention
Subjects:
Adolescent
Adult
Antitubercular Agents - administration & dosage
Antitubercular Agents - therapeutic use
bedaquiline
Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis
combination treatment
delamanid
Diarylquinolines - administration & dosage
Diarylquinolines - therapeutic use
Dispatch
Drug therapy
Drug Therapy, Combination
effectiveness
Extensively Drug-Resistant Tuberculosis - drug therapy
Female
Humans
Male
MDR-TB
Microbial drug resistance
Nitroimidazoles - administration & dosage
Nitroimidazoles - therapeutic use
Oxazoles - administration & dosage
Oxazoles - therapeutic use
Public health
Respiratory system agents
Rifampin
Tuberculosis
Tuberculosis, Pulmonary - drug therapy
Tuberculosis, Pulmonary - microbiology
XDR-TB
Young Adult
multidrug resistance
bacteria
combination treatment
mycobacteria
Russia
the Netherlands
antimicrobial resistance
safety
delamanid
MDR TB
effectiveness
Europe
XDR TB
tuberculosis
United Kingdom
pulmonary
multidrug-resistant tuberculosis
Switzerland
bedaquiline
TB
respiratory infections
India
Mycobacterium tuberculosis
tolerability
Italy
ISSN:1080-6040, 1080-6059, 1080-6059
Online Access:Get full text
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Description
Summary:We report the experiences of 5 patients taking bedaquiline with delamanid in combination: 1 patient was cured; 3 culture converted, with 2 continuing and 1 changing therapy; and 1 died from respiratory insufficiency. For 2 patients, QT-interval prolongation but no arrhythmias occurred. Use of this therapy is justified for patients with limited options.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1080-6040
1080-6059
1080-6059
DOI:10.3201/eid2310.170834