Comparative Sequence Analyses of La Crosse Virus Strain Isolated from Patient with Fatal Encephalitis, Tennessee, USA
We characterized a La Crosse virus (LACV) isolate from the brain of a child who died of encephalitis-associated complications in eastern Tennessee, USA, during summer 2012. We compared the isolate with LACV sequences from mosquitoes collected near the child's home just after his postmortem diag...
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| Veröffentlicht in: | Emerging infectious diseases Jg. 21; H. 5; S. 833 - 836 |
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United States
U.S. National Center for Infectious Diseases
01.05.2015
Centers for Disease Control and Prevention |
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| Abstract | We characterized a La Crosse virus (LACV) isolate from the brain of a child who died of encephalitis-associated complications in eastern Tennessee, USA, during summer 2012. We compared the isolate with LACV sequences from mosquitoes collected near the child's home just after his postmortem diagnosis. In addition, we conducted phylogenetic analyses of these and other sequences derived from LACV strains representing varied temporal, geographic, and ecologic origins. Consistent with historical findings, results of these analyses indicate that a limited range of LACV lineage I genotypes is associated with severe clinical outcomes. |
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| AbstractList | We characterized a La Crosse virus (LACV) isolate from the brain of a child who died of encephalitis-associated complications in eastern Tennessee, USA, during summer 2012. We compared the isolate with LACV sequences from mosquitoes collected near the child's home just after his postmortem diagnosis. In addition, we conducted phylogenetic analyses of these and other sequences derived from LACV strains representing varied temporal, geographic, and ecologic origins. Consistent with historical findings, results of these analyses indicate that a limited range of LACV lineage I genotypes is associated with severe clinical outcomes.We characterized a La Crosse virus (LACV) isolate from the brain of a child who died of encephalitis-associated complications in eastern Tennessee, USA, during summer 2012. We compared the isolate with LACV sequences from mosquitoes collected near the child's home just after his postmortem diagnosis. In addition, we conducted phylogenetic analyses of these and other sequences derived from LACV strains representing varied temporal, geographic, and ecologic origins. Consistent with historical findings, results of these analyses indicate that a limited range of LACV lineage I genotypes is associated with severe clinical outcomes. We characterized a La Crosse virus (LACV) isolate from the brain of a child who died of encephalitis-associated complications in eastern Tennessee, USA, during summer 2012. We compared the isolate with LACV sequences from mosquitoes collected near the child's home just after his postmortem diagnosis. In addition, we conducted phylogenetic analyses of these and other sequences derived from LACV strains representing varied temporal, geographic, and ecologic origins. Consistent with historical findings, results of these analyses indicate that a limited range of LACV lineage I genotypes is associated with severe clinical outcomes. We verified the transovarial maintenance and ecologic role of the endemic vector in this region. We characterized a La Crosse virus (LACV) isolate from the brain of a child who died of encephalitis-associated complications in eastern Tennessee, USA, during summer 2012. We compared the isolate with LACV sequences from mosquitoes collected near the child’s home just after his postmortem diagnosis. In addition, we conducted phylogenetic analyses of these and other sequences derived from LACV strains representing varied temporal, geographic, and ecologic origins. Consistent with historical findings, results of these analyses indicate that a limited range of LACV lineage I genotypes is associated with severe clinical outcomes. |
| Audience | Professional Academic |
| Author | Lanciotti, Robert S. Ulloa, Armando Velez, Jason O. Moncayo, Abelardo Freyman, Kimberly Paulsen, Dave Fryxell, Rebecca Trout Lambert, Amy J. |
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| Cites_doi | 10.1016/0042-6822(83)90271-4 10.4269/ajtmh.2006.75.491 10.1371/journal.pone.0006954 10.1016/S0042-6822(95)80001-8 10.1128/JCM.43.4.1885-1889.2005 10.1128/JCM.36.11.3332-3336.1998 10.1099/vir.0.2008/002253-0 10.1006/viro.1993.1213 10.1099/0022-1317-68-12-3057 10.1603/0022-2585-37.4.559 10.1128/JCM.34.5.1184-1188.1996 10.1016/S0168-1702(97)01437-8 10.1099/vir.0.051359-0 |
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| Keywords | mosquitoes sequence viruses vector-borne infections United States children encephalitis Tennessee La Crosse virus |
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| References | Lambert (key-10.3201/eid2105.141992-201504170842-R7) 2005; 43 Grady (key-10.3201/eid2105.141992-201504170842-R1) 1987; 68 Huhtamo (key-10.3201/eid2105.141992-201504170842-R8) 2013; 94 Roberts (key-10.3201/eid2105.141992-201504170842-R4) 1995; 206 Lambert (key-10.3201/eid2105.141992-201504170842-R11) 2008; 89 Armstrong (key-10.3201/eid2105.141992-201504170842-R13) 2006; 75 Jacoby (key-10.3201/eid2105.141992-201504170842-R2) 1993; 193 Chandler (key-10.3201/eid2105.141992-201504170842-R14) 1998; 36 Haddow (key-10.3201/eid2105.141992-201504170842-R6) 2009; 4 Kuno (key-10.3201/eid2105.141992-201504170842-R10) 1996; 34 Huang (key-10.3201/eid2105.141992-201504170842-R12) 1997; 48 key-10.3201/eid2105.141992-201504170842-R9 Nasci (key-10.3201/eid2105.141992-201504170842-R5) 2000; 37 Cabradilla (key-10.3201/eid2105.141992-201504170842-R3) 1983; 128 9774588 - J Clin Microbiol. 1998 Nov;36(11):3332-6 15815013 - J Clin Microbiol. 2005 Apr;43(4):1885-9 18796727 - J Gen Virol. 2008 Oct;89(Pt 10):2580-5 9175252 - Virus Res. 1997 May;48(2):143-8 8460503 - Virology. 1993 Apr;193(2):993-6 3694177 - J Gen Virol. 1987 Dec;68 ( Pt 12):3057-71 7831835 - Virology. 1995 Jan 10;206(1):742-5 23515020 - J Gen Virol. 2013 Jun;94(Pt 6):1242-8 19742311 - PLoS One. 2009;4(9):e6954 16968927 - Am J Trop Med Hyg. 2006 Sep;75(3):491-6 10916297 - J Med Entomol. 2000 Jul;37(4):559-70 6684362 - Virology. 1983 Jul 30;128(2):463-8 8727900 - J Clin Microbiol. 1996 May;34(5):1184-8 |
| References_xml | – volume: 128 start-page: 463 year: 1983 ident: key-10.3201/eid2105.141992-201504170842-R3 article-title: Molecular cloning and sequencing of the La Crosse virus S RNA. publication-title: Virology doi: 10.1016/0042-6822(83)90271-4 – ident: key-10.3201/eid2105.141992-201504170842-R9 – volume: 75 start-page: 491 year: 2006 ident: key-10.3201/eid2105.141992-201504170842-R13 article-title: A new genetic variant of La Crosse (Bunyaviridae) isolated from New England. publication-title: Am J Trop Med Hyg doi: 10.4269/ajtmh.2006.75.491 – volume: 4 start-page: e6954 year: 2009 ident: key-10.3201/eid2105.141992-201504170842-R6 article-title: Assessing risk in focal arboviral infections: are we missing the big or little picture? publication-title: PLoS ONE doi: 10.1371/journal.pone.0006954 – volume: 206 start-page: 742 year: 1995 ident: key-10.3201/eid2105.141992-201504170842-R4 article-title: Completion of the La Crosse virus genome sequence and genetic comparisons of the L proteins of the Bunyaviridae. publication-title: Virology doi: 10.1016/S0042-6822(95)80001-8 – volume: 43 start-page: 1885 year: 2005 ident: key-10.3201/eid2105.141992-201504170842-R7 article-title: Nucleic acid amplification assays for detection of La Crosse virus RNA. publication-title: J Clin Microbiol doi: 10.1128/JCM.43.4.1885-1889.2005 – volume: 36 start-page: 3332 year: 1998 ident: key-10.3201/eid2105.141992-201504170842-R14 article-title: Characterization of La Crosse virus RNA in autopsied central nervous system tissues. publication-title: J Clin Microbiol doi: 10.1128/JCM.36.11.3332-3336.1998 – volume: 89 start-page: 2580 year: 2008 ident: key-10.3201/eid2105.141992-201504170842-R11 article-title: Molecular characterization of medically important viruses of the genus Orthobunyavirus. publication-title: J Gen Virol doi: 10.1099/vir.0.2008/002253-0 – volume: 193 start-page: 993 year: 1993 ident: key-10.3201/eid2105.141992-201504170842-R2 article-title: Expression of the La Crosse M segment proteins in a recombinant vaccinia expression system mediates pH-dependent cellular fusion. publication-title: Virology doi: 10.1006/viro.1993.1213 – volume: 68 start-page: 3057 year: 1987 ident: key-10.3201/eid2105.141992-201504170842-R1 article-title: The sequence of the M RNA of an isolate of La Crosse virus. publication-title: J Gen Virol doi: 10.1099/0022-1317-68-12-3057 – volume: 37 start-page: 559 year: 2000 ident: key-10.3201/eid2105.141992-201504170842-R5 article-title: La Crosse encephalitis virus habitat associations in Nicholas County, West Virginia. publication-title: J Med Entomol doi: 10.1603/0022-2585-37.4.559 – volume: 34 start-page: 1184 year: 1996 ident: key-10.3201/eid2105.141992-201504170842-R10 article-title: Detecting bunyaviruses of the Bunyamwera and California serogroups by a PCR technique. publication-title: J Clin Microbiol doi: 10.1128/JCM.34.5.1184-1188.1996 – volume: 48 start-page: 143 year: 1997 ident: key-10.3201/eid2105.141992-201504170842-R12 article-title: Evidence that fatal human infections with La Crosse virus may be associated with a narrow range of genotypes. publication-title: Virus Res doi: 10.1016/S0168-1702(97)01437-8 – volume: 94 start-page: 1242 year: 2013 ident: key-10.3201/eid2105.141992-201504170842-R8 article-title: Isolation and full genomic characterization of Batai virus from mosquitoes, Italy 2009. publication-title: J Gen Virol doi: 10.1099/vir.0.051359-0 – reference: 7831835 - Virology. 1995 Jan 10;206(1):742-5 – reference: 9175252 - Virus Res. 1997 May;48(2):143-8 – reference: 6684362 - Virology. 1983 Jul 30;128(2):463-8 – reference: 9774588 - J Clin Microbiol. 1998 Nov;36(11):3332-6 – reference: 15815013 - J Clin Microbiol. 2005 Apr;43(4):1885-9 – reference: 3694177 - J Gen Virol. 1987 Dec;68 ( Pt 12):3057-71 – reference: 16968927 - Am J Trop Med Hyg. 2006 Sep;75(3):491-6 – reference: 8727900 - J Clin Microbiol. 1996 May;34(5):1184-8 – reference: 18796727 - J Gen Virol. 2008 Oct;89(Pt 10):2580-5 – reference: 23515020 - J Gen Virol. 2013 Jun;94(Pt 6):1242-8 – reference: 19742311 - PLoS One. 2009;4(9):e6954 – reference: 10916297 - J Med Entomol. 2000 Jul;37(4):559-70 – reference: 8460503 - Virology. 1993 Apr;193(2):993-6 |
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| Snippet | We characterized a La Crosse virus (LACV) isolate from the brain of a child who died of encephalitis-associated complications in eastern Tennessee, USA, during... We verified the transovarial maintenance and ecologic role of the endemic vector in this region. We characterized a La Crosse virus (LACV) isolate from the... |
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| SubjectTerms | Animals Child children Comparative Sequence Analyses of La Crosse Virus Strain Isolated from Patient with Fatal Encephalitis, Tennessee, USA Encephalitis Encephalitis, California - diagnosis Encephalitis, California - epidemiology Encephalitis, California - transmission Encephalitis, California - virology Fatal Outcome Genome, Viral Genomics Health aspects Humans La Crosse virus La Crosse virus - classification La Crosse virus - genetics Male Phylogeny RNA RNA, Viral sequence Serotyping Tennessee Tennessee - epidemiology vector-borne infections viruses |
| Title | Comparative Sequence Analyses of La Crosse Virus Strain Isolated from Patient with Fatal Encephalitis, Tennessee, USA |
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