Comparative Sequence Analyses of La Crosse Virus Strain Isolated from Patient with Fatal Encephalitis, Tennessee, USA

We characterized a La Crosse virus (LACV) isolate from the brain of a child who died of encephalitis-associated complications in eastern Tennessee, USA, during summer 2012. We compared the isolate with LACV sequences from mosquitoes collected near the child's home just after his postmortem diag...

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Bibliographic Details
Published in:Emerging infectious diseases Vol. 21; no. 5; pp. 833 - 836
Main Authors: Lambert, Amy J., Fryxell, Rebecca Trout, Freyman, Kimberly, Ulloa, Armando, Velez, Jason O., Paulsen, Dave, Lanciotti, Robert S., Moncayo, Abelardo
Format: Journal Article
Language:English
Published: United States U.S. National Center for Infectious Diseases 01.05.2015
Centers for Disease Control and Prevention
Subjects:
Animals
Child
children
Comparative Sequence Analyses of La Crosse Virus Strain Isolated from Patient with Fatal Encephalitis, Tennessee, USA
Encephalitis
Encephalitis, California - diagnosis
Encephalitis, California - epidemiology
Encephalitis, California - transmission
Encephalitis, California - virology
Fatal Outcome
Genome, Viral
Genomics
Health aspects
Humans
La Crosse virus
La Crosse virus - classification
La Crosse virus - genetics
Male
Phylogeny
RNA
RNA, Viral
sequence
Serotyping
Tennessee
Tennessee - epidemiology
vector-borne infections
viruses
Tennessee
mosquitoes
sequence
viruses
vector-borne infections
United States
children
encephalitis
Tennessee
La Crosse virus
ISSN:1080-6040, 1080-6059, 1080-6059
Online Access:Get full text
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Description
Summary:We characterized a La Crosse virus (LACV) isolate from the brain of a child who died of encephalitis-associated complications in eastern Tennessee, USA, during summer 2012. We compared the isolate with LACV sequences from mosquitoes collected near the child's home just after his postmortem diagnosis. In addition, we conducted phylogenetic analyses of these and other sequences derived from LACV strains representing varied temporal, geographic, and ecologic origins. Consistent with historical findings, results of these analyses indicate that a limited range of LACV lineage I genotypes is associated with severe clinical outcomes.
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ISSN:1080-6040
1080-6059
1080-6059
DOI:10.3201/eid2105.141992