Differences in Neuropathogenesis of Encephalitic California Serogroup Viruses

The California serogroup of orthobunyaviruses comprises a group of mosquitoborne viruses, including La Crosse (LACV), snowshoe hare (SSHV), Tahyna (TAHV), Jamestown Canyon (JCV), and Inkoo (INKV) viruses, that cause neurologic disease in humans of differing ages with varying incidences. To determine...

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Bibliographic Details
Published in:Emerging infectious diseases Vol. 25; no. 4; pp. 728 - 738
Main Authors: Evans, Alyssa B., Winkler, Clayton W., Peterson, Karin E.
Format: Journal Article
Language:English
Published: United States U.S. National Center for Infectious Diseases 01.04.2019
Centers for Disease Control and Prevention
Subjects:
Age Factors
Animals
Antigens
Biochemistry
brain
Cell death
Cells, Cultured
Cluster Analysis
Comparative analysis
Differences in Neuropathogenesis of Encephalitic California Serogroup Viruses
disease
Disease Models, Animal
Encephalitis Virus, California - classification
Encephalitis Virus, California - genetics
Encephalitis Virus, California - pathogenicity
Encephalitis, California - diagnosis
Encephalitis, California - epidemiology
Encephalitis, California - virology
Genes, Viral
Geography, Medical
Global Health
Humans
Incidence
Mice
Nervous system diseases
orthobunyaviruses
pathogenicity
Public Health Surveillance
Sequence Analysis, DNA
Serogroup
susceptibility
Viral antigens
virus replication
California
Inkoo virus
viruses
mouse model
United States
virus replication
Tahyna virus
La Crosse virus
brain
neuropathogenesis
neurons
C57BL/6
pathogenicity
vector-borne infections
mosquitoborne viruses
California serogroup viruses
encephalitis
orthobunyaviruses
snowshoe hare virus
Jamestown Canyon virus
ISSN:1080-6040, 1080-6059, 1080-6059
Online Access:Get full text
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Summary:The California serogroup of orthobunyaviruses comprises a group of mosquitoborne viruses, including La Crosse (LACV), snowshoe hare (SSHV), Tahyna (TAHV), Jamestown Canyon (JCV), and Inkoo (INKV) viruses, that cause neurologic disease in humans of differing ages with varying incidences. To determine how the pathogenesis of these viruses differs, we compared their ability to induce disease in mice and replicate and induce cell death in vitro. In mice, LACV, TAHV, and SSHV induced neurologic disease after intraperitoneal and intranasal inoculation, and JCV induced disease only after intranasal inoculation. INKV rarely induced disease, which correlated with less viral antigen in the brain than the other viruses. In vitro, all viruses replicated to high titers; however, LACV, SSHV, and TAHV induced high cell death, whereas JCV and INKV did not. Results demonstrated that CSG viruses differ in neuropathogenesis in vitro and in vivo, which correlates with the differences in pathogenesis reported in humans.
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ISSN:1080-6040
1080-6059
1080-6059
DOI:10.3201/eid2504.181016