Envelope Deglycosylation Enhances Antigenicity of HIV-1 gp41 Epitopes for Both Broad Neutralizing Antibodies and Their Unmutated Ancestor Antibodies

The HIV-1 gp41 envelope (Env) membrane proximal external region (MPER) is an important vaccine target that in rare subjects can elicit neutralizing antibodies. One mechanism proposed for rarity of MPER neutralizing antibody generation is lack of reverted unmutated ancestor (putative naive B cell rec...

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Bibliographic Details
Published in:	PLoS pathogens Vol. 7; no. 9; p. e1002200
Main Authors:	Ma, Ben-Jiang, Alam, S. Munir, Go, Eden P., Lu, Xiaozhi, Desaire, Heather, Tomaras, Georgia D., Bowman, Cindy, Sutherland, Laura L., Scearce, Richard M., Santra, Sampa, Letvin, Norman L., Kepler, Thomas B., Liao, Hua-Xin, Haynes, Barton F.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.09.2011 Public Library of Science (PLoS)
Subjects:	Acquired immune deficiency syndrome AIDS Animals Antibodies, Monoclonal - immunology Antibodies, Neutralizing - immunology Antigen-antibody reactions B-Lymphocytes - immunology Biology env Gene Products, Human Immunodeficiency Virus - chemistry env Gene Products, Human Immunodeficiency Virus - immunology Epitopes - immunology Experiments Flow cytometry Glycosylation HIV (Viruses) HIV antibodies HIV Envelope Protein gp41 - chemistry HIV Envelope Protein gp41 - immunology HIV-1 - immunology Humans Hypotheses Immunization Immunogenicity Immunology Macaca mulatta - immunology Medicine Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase - metabolism Peptides Physiological aspects Proteins Vaccines United States
ISSN:	1553-7374, 1553-7366, 1553-7374
Online Access:	Get full text
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