Human telomeric position effect is determined by chromosomal context and telomeric chromatin integrity

We investigated the influence of telomere proximity and composition on the expression of an EGFP reporter gene in human cells. In transient transfection assays, telomeric DNA does not repress EGFP but rather slightly increases its expression. In contrast, in stable cell lines, the same reporter cons...

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Bibliographic Details
Published in:	EMBO reports Vol. 3; no. 11; pp. 1055 - 1061
Main Authors:	Koering, Catherine Elaine, Pollice, Alessandra, Zibella, Maria Pia, Bauwens, Serge, Puisieux, Alain, Brunori, Michele, Brun, Christine, Martins, Luis, Sabatier, Laure, Pulitzer, John F., Gilson, Eric
Format:	Journal Article
Language:	English
Published:	Chichester, UK John Wiley & Sons, Ltd 01.11.2002 Nature Publishing Group UK Springer Nature B.V EMBO Press
Subjects:	Biochemistry, Molecular Biology Bioinformatics Chromatin - metabolism Chromosomes, Human - metabolism Computer Science Gene Expression Regulation Gene Silencing Genes, Reporter Humans Life Sciences Molecular biology Scientific Report Telomere - metabolism Telomeric Repeat Binding Protein 1 - genetics Telomeric Repeat Binding Protein 1 - metabolism Tumor Cells, Cultured
ISSN:	1469-221X, 1469-3178
Online Access:	Get full text
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