HLTF's Ancient HIRAN Domain Binds 3' DNA Ends to Drive Replication Fork Reversal

Stalled replication forks are a critical problem for the cell because they can lead to complex genome rearrangements that underlie cell death and disease. Processes such as DNA damage tolerance and replication fork reversal protect stalled forks from these events. A central mediator of these DNA dam...

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Veröffentlicht in:	Molecular cell Jg. 58; H. 6; S. 1090 - 1100
Hauptverfasser:	Kile, Andrew C, Chavez, Diana A, Bacal, Julien, Eldirany, Sherif, Korzhnev, Dmitry M, Bezsonova, Irina, Eichman, Brandt F, Cimprich, Karlene A
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 18.06.2015
Schlagworte:	Amino Acid Sequence Base Sequence Binding Sites - genetics Blotting, Western Cell Line, Tumor Crystallography, X-Ray DNA - chemistry DNA - genetics DNA - metabolism DNA Replication DNA, Single-Stranded - chemistry DNA, Single-Stranded - genetics DNA, Single-Stranded - metabolism DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Humans Magnetic Resonance Spectroscopy Models, Genetic Models, Molecular Molecular Sequence Data Mutation Nucleic Acid Conformation Protein Binding Protein Structure, Tertiary RNA Interference Sequence Homology, Amino Acid Sequence Homology, Nucleic Acid Transcription Factors - chemistry Transcription Factors - genetics Transcription Factors - metabolism
ISSN:	1097-4164
Online-Zugang:	Weitere Angaben
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