Reassortant Group A Rotavirus from Straw-colored Fruit Bat ( Eidolon helvum )

Bats are known reservoirs of viral zoonoses. We report genetic characterization of a bat rotavirus (Bat/KE4852/07) detected in the feces of a straw-colored fruit bat (Eidolon helvum). Six bat rotavirus genes (viral protein [VP] 2, VP6, VP7, nonstructural protein [NSP] 2, NSP3, and NSP5) shared ances...

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Bibliographic Details
Published in:Emerging infectious diseases Vol. 16; no. 12; pp. 1844 - 1852
Main Authors: Esona, Mathew D., Mijatovic-Rustempasic, Slavica, Conrardy, Christina, Tong, Suxiang, Kuzmin, Ivan V., Agwanda, Bernard, Breiman, Robert F., Banyai, Krisztian, Niezgoda, Michael, Rupprecht, Charles E., Gentsch, Jon R., Bowen, Michael D.
Format: Journal Article
Language:English
Published: United States U.S. National Center for Infectious Diseases 01.12.2010
Centers for Disease Control and Prevention
Subjects:
Amino Acid Sequence
Amino acids
Animals
Capsid Proteins - genetics
Chiroptera - virology
Disease Reservoirs - virology
Eidolon helvum
Feces - virology
Genes, Viral - genetics
Genetic aspects
Glycoproteins - genetics
heterologous genome segments
Humans
Kenya
Marburg virus disease
Molecular Sequence Data
Phylogeny
Reassortant Viruses - classification
Reassortant Viruses - genetics
Reassortant Viruses - isolation & purification
reassortment
rotavirus
Rotavirus - classification
Rotavirus - genetics
Rotavirus - isolation & purification
Rotavirus Infections - transmission
Rotavirus Infections - virology
Sequence Alignment
Straw-colored fruit bat
Toxins, Biological - genetics
Viral Core Proteins - genetics
Viral Nonstructural Proteins - genetics
Viral proteins
Viral Proteins - genetics
viruses
Zoonoses - transmission
Zoonoses - virology
Kenya
ISSN:1080-6040, 1080-6059, 1080-6059
Online Access:Get full text
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Summary:Bats are known reservoirs of viral zoonoses. We report genetic characterization of a bat rotavirus (Bat/KE4852/07) detected in the feces of a straw-colored fruit bat (Eidolon helvum). Six bat rotavirus genes (viral protein [VP] 2, VP6, VP7, nonstructural protein [NSP] 2, NSP3, and NSP5) shared ancestry with other mammalian rotaviruses but were distantly related. The VP4 gene was nearly identical to that of human P[6] rotavirus strains, and the NSP4 gene was closely related to those of previously described mammalian rotaviruses, including human strains. Analysis of partial sequence of the VP1 gene indicated that it was distinct from cognate genes of other rotaviruses. No sequences were obtained for the VP3 and NSP1 genes of the bat rotavirus. This rotavirus was designated G25-P[6]-I15-R8(provisional)-C8-Mx-Ax-N8-T11-E2-H10. Results suggest that several reassortment events have occurred between human, animal, and bat rotaviruses. Several additional rotavirus strains were detected in bats.
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ISSN:1080-6040
1080-6059
1080-6059
DOI:10.3201/eid1612.101089