Interplay between metabolic identities in the intestinal crypt supports stem cell function

The glycolytic activity of Paneth cells provides lactate, which is required by self-renewing intestinal stem cells for oxidative metabolism to activate p38 MAP kinase, ensuring regeneration of a mature crypt. Metabolism and gut regeneration Small intestine crypts are regenerated throughout life than...

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Bibliographic Details
Published in:	Nature (London) Vol. 543; no. 7645; pp. 424 - 427
Main Authors:	Rodríguez-Colman, Maria J., Schewe, Matthias, Meerlo, Maaike, Stigter, Edwin, Gerrits, Johan, Pras-Raves, Mia, Sacchetti, Andrea, Hornsveld, Marten, Oost, Koen C., Snippert, Hugo J., Verhoeven-Duif, Nanda, Fodde, Riccardo, Burgering, Boudewijn M. T.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 16.03.2017 Nature Publishing Group
Subjects:	13/100 14 14/19 14/34 14/35 38 38/77 631/45/320 631/532/1360 631/532/2139 96 96/1 96/31 Animals Cell Differentiation Cell Self Renewal Culture Media, Conditioned - chemistry Culture Media, Conditioned - pharmacology Gene expression Glycolysis Homeostasis Humanities and Social Sciences Intestinal Mucosa - cytology Intestinal Mucosa - metabolism Intestine, Small - cytology Intestine, Small - metabolism Intestines Lactic Acid - metabolism letter Metabolism Mice Mitochondria Mitochondria - metabolism multidisciplinary Organoids - cytology Organoids - drug effects Organoids - metabolism Oxidative Phosphorylation p38 Mitogen-Activated Protein Kinases - metabolism Paneth Cells - cytology Paneth Cells - metabolism Physiological aspects Physiological research Reactive Oxygen Species - metabolism Receptors, G-Protein-Coupled - metabolism Science Signal Transduction Small intestine Stem cells Stem Cells - cytology Stem Cells - physiology Wnt3A Protein - pharmacology
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
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