The prevalence of symptoms in 24,410 adults infected by the novel coronavirus (SARS-CoV-2; COVID-19): A systematic review and meta-analysis of 148 studies from 9 countries

To limit the spread of SARS-CoV-2, an evidence-based understanding of the symptoms is critical to inform guidelines for quarantining and testing. The most common features are purported to be fever and a new persistent cough, although the global prevalence of these symptoms remains unclear. The aim o...

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Vydáno v:	PloS one Ročník 15; číslo 6; s. e0234765
Hlavní autoři:	Grant, Michael C., Geoghegan, Luke, Arbyn, Marc, Mohammed, Zakaria, McGuinness, Luke, Clarke, Emily L., Wade, Ryckie G.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Public Library of Science 23.06.2020 Public Library of Science (PLoS)
Témata:	Adult Adults Bias Biology and Life Sciences Coronavirus infections Coronavirus Infections - epidemiology Coronavirus Infections - pathology Coronaviruses Cough Cough - epidemiology COVID-19 Diagnosis Distribution Extracorporeal membrane oxygenation Fever Fever - epidemiology Global Health Heterogeneity Humans Laboratory tests Medical research Medicine and Health Sciences Meta-analysis Middle Aged Oxygenation Pandemics Physical Sciences Pneumonia, Viral - epidemiology Pneumonia, Viral - pathology Preprints as Topic Prevalence Research and Analysis Methods Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Studies Ventilation Viral diseases United Kingdom United Kingdom > UK
ISSN:	1932-6203, 1932-6203
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Shrnutí:	To limit the spread of SARS-CoV-2, an evidence-based understanding of the symptoms is critical to inform guidelines for quarantining and testing. The most common features are purported to be fever and a new persistent cough, although the global prevalence of these symptoms remains unclear. The aim of this systematic review is to determine the prevalence of symptoms associated with COVID-19 worldwide. We searched PubMed, Embase, CINAHL, AMED, medRxiv and bioRxiv on 5th April 2020 for studies of adults (>16 years) with laboratory test confirmed COVID-19. No language or publication status restrictions were applied. Data were independently extracted by two review authors into standardised forms. All datapoints were independently checked by three other review authors. A random-effects model for pooling of binomial data was applied to estimate the prevalence of symptoms, subgrouping estimates by country. I2 was used to assess inter-study heterogeneity. Of 851 unique citations, 148 articles were included which comprised 24,410 adults with confirmed COVID-19 from 9 countries. The most prevalent symptoms were fever (78% [95% CI 75%-81%]; 138 studies, 21,701 patients; I2 94%), a cough (57% [95% CI 54%-60%]; 138 studies, 21,682 patients; I2 94%) and fatigue (31% [95% CI 27%-35%]; 78 studies, 13,385 patients; I2 95%). Overall, 19% of hospitalised patients required non-invasive ventilation (44 studies, 6,513 patients), 17% required intensive care (33 studies, 7504 patients), 9% required invasive ventilation (45 studies, 6933 patients) and 2% required extra-corporeal membrane oxygenation (12 studies, 1,486 patients). The mortality rate was 7% (73 studies, 10,402 patients). We confirm that fever and cough are the most prevalent symptoms of adults infected by SARS-CoV-2. However, there is a large proportion of infected adults which symptoms-alone do not identify.
Bibliografie:	ObjectType-Article-2 SourceType-Scholarly Journals-1 content type line 14 ObjectType-Feature-3 ObjectType-Evidence Based Healthcare-1 ObjectType-Article-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3 Competing Interests: The authors have declared that no competing interests exist.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0234765