Mitochondrial oxidative stress drives tumor progression and metastasis: should we use antioxidants as a key component of cancer treatment and prevention?

The functional role of oxidative stress in cancer pathogenesis has long been a hotly debated topic. A study published this month in BMC Cancer by Goh et al. , directly addresses this issue by using a molecular genetic approach, via an established mouse animal model of human breast cancer. More speci...

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Bibliographic Details
Published in:	BMC medicine Vol. 9; no. 1; p. 62
Main Authors:	Sotgia, Federica, Martinez-Outschoorn, Ubaldo E, Lisanti, Michael P
Format:	Journal Article
Language:	English
Published:	London BioMed Central 23.05.2011 BioMed Central Ltd BMC
Subjects:	Analysis Animals Antineoplastic Agents - therapeutic use Antioxidants Antioxidants - therapeutic use Biomedicine Breast Neoplasms - drug therapy Breast Neoplasms - pathology Cancer Catalase - genetics Catalase - metabolism Commentary Complications and side effects Development and progression Disease Models, Animal Drug therapy Female Gene Expression Health aspects Humans Medicine Medicine & Public Health Mice Mitochondria - metabolism Neoplasm Metastasis - pathology Neoplasm Metastasis - prevention & control Neoplasms - drug therapy Neoplasms - pathology Oxidative Stress Prevention Protein Transport Risk factors Rodent Diseases - drug therapy Rodent Diseases - pathology United States United Kingdom Cancer Associate Fibroblast Mitochondrial Oxidative Stress Tumor Stroma Mitochondrial SOD2 Triple Negative Breast Cancer Patient
ISSN:	1741-7015, 1741-7015
Online Access:	Get full text
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