Mitochondrial oxidative stress drives tumor progression and metastasis: should we use antioxidants as a key component of cancer treatment and prevention?

The functional role of oxidative stress in cancer pathogenesis has long been a hotly debated topic. A study published this month in BMC Cancer by Goh et al. , directly addresses this issue by using a molecular genetic approach, via an established mouse animal model of human breast cancer. More speci...

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Vydáno v:	BMC medicine Ročník 9; číslo 1; s. 62
Hlavní autoři:	Sotgia, Federica, Martinez-Outschoorn, Ubaldo E, Lisanti, Michael P
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London BioMed Central 23.05.2011 BioMed Central Ltd BMC
Témata:	Analysis Animals Antineoplastic Agents - therapeutic use Antioxidants Antioxidants - therapeutic use Biomedicine Breast Neoplasms - drug therapy Breast Neoplasms - pathology Cancer Catalase - genetics Catalase - metabolism Commentary Complications and side effects Development and progression Disease Models, Animal Drug therapy Female Gene Expression Health aspects Humans Medicine Medicine & Public Health Mice Mitochondria - metabolism Neoplasm Metastasis - pathology Neoplasm Metastasis - prevention & control Neoplasms - drug therapy Neoplasms - pathology Oxidative Stress Prevention Protein Transport Risk factors Rodent Diseases - drug therapy Rodent Diseases - pathology United States United Kingdom Cancer Associate Fibroblast Mitochondrial Oxidative Stress Tumor Stroma Mitochondrial SOD2 Triple Negative Breast Cancer Patient
ISSN:	1741-7015, 1741-7015
On-line přístup:	Získat plný text
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