Genetic Characterization of West Nile Virus Lineage 2, Greece, 2010

We conducted a complete genome analysis of a West Nile virus detected in Culex pipiens mosquitoes during a severe outbreak of human West Nile disease in Greece 2010. The virus showed closest genetic relationship to the lineage 2 strain that emerged in Hungary in 2004; increased virulence may be asso...

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Bibliographic Details
Published in:Emerging infectious diseases Vol. 17; no. 5; pp. 920 - 922
Main Authors: Papa, Anna, Bakonyi, Tamás, Xanthopoulou, Kyriaki, Vázquez, Ana, Tenorio, Antonio, Nowotny, Norbert
Format: Journal Article
Language:English
Published: United States U.S. National Center for Infectious Diseases 01.05.2011
Centers for Disease Control and Prevention
Subjects:
Amino Acid Substitution - genetics
Amino acids
Animals
Chemical properties
Culex - virology
Dispatch
flavivirus
Genetic aspects
Genetic Linkage - genetics
Greece
human
Humans
Infection
lineage 2
Molecular Sequence Data
Mosquitoes
neuroinvasive
Phylogeny
RNA, Viral - genetics
Viral Nonstructural Proteins - genetics
viruses
West Nile fever
West Nile Fever - virology
West Nile virus
West Nile virus - classification
West Nile virus - genetics
West Nile virus - isolation & purification
West Nile virus - pathogenicity
Greece
Hungary
ISSN:1080-6040, 1080-6059, 1080-6059
Online Access:Get full text
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Summary:We conducted a complete genome analysis of a West Nile virus detected in Culex pipiens mosquitoes during a severe outbreak of human West Nile disease in Greece 2010. The virus showed closest genetic relationship to the lineage 2 strain that emerged in Hungary in 2004; increased virulence may be associated with amino acid substitution H249P.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1080-6040
1080-6059
1080-6059
DOI:10.3201/eid1705.101759