The association between cigarette smoking and inflammation: The Genetic Epidemiology Network of Arteriopathy (GENOA) study

To inform the study and regulation of emerging tobacco products, we sought to identify sensitive biomarkers of tobacco-induced subclinical cardiovascular damage by testing the cross-sectional associations of smoking with 17 biomarkers of inflammation in 2,702 GENOA study participants belonging to si...

Full description

Saved in:
Bibliographic Details
Published in:PloS one Vol. 12; no. 9; p. e0184914
Main Authors: Tibuakuu, Martin, Kamimura, Daisuke, Kianoush, Sina, DeFilippis, Andrew P., Al Rifai, Mahmoud, Reynolds, Lindsay M., White, Wendy B., Butler, Kenneth R., Mosley, Thomas H., Turner, Stephen T., Kullo, Iftikhar J., Hall, Michael E., Blaha, Michael J.
Format: Journal Article
Language:English
Published: United States Public Library of Science 18.09.2017
Public Library of Science (PLoS)
Subjects:
Aged
Atherosclerosis
Biological markers
Biology and Life Sciences
Biomarkers
Biomarkers - blood
Blood pressure
C-reactive protein
C-Reactive Protein - metabolism
Cardiology
Cardiovascular disease
Cell adhesion & migration
Cigarette smoking
Cigarettes
Complications and side effects
Cytokines
Damage detection
Diabetes
Disease prevention
DNA methylation
Epidemiology
Federal regulation
Female
Genetic aspects
Health risk assessment
Heart
Humans
Hypertension
Inflammation
Inflammation - blood
Inflammation - epidemiology
Male
Mathematical models
Medicine
Medicine and Health Sciences
Middle Aged
Molecular Epidemiology
People and places
Physiological aspects
Prevalence
Proteins
Quality control
Risk factors
Smoking
Smoking - blood
Smoking - epidemiology
Tobacco
Tumor necrosis factor-TNF
United States
United States > US
Baltimore Maryland
ISSN:1932-6203, 1932-6203
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To inform the study and regulation of emerging tobacco products, we sought to identify sensitive biomarkers of tobacco-induced subclinical cardiovascular damage by testing the cross-sectional associations of smoking with 17 biomarkers of inflammation in 2,702 GENOA study participants belonging to sibships ascertained on the basis of hypertension. Cigarette smoking was assessed by status, intensity (number of cigarettes per day), burden (pack-years of smoking), and time since quitting. We modeled biomarkers as geometric mean (GM) ratios using generalized estimating equations (GEE). The mean age of participants was 61 ±10 years; 64.5% were women and 54.4% African American. The prevalence of smoking was 12.2%. After adjusting for potential confounders, 6 of 17 biomarkers were significantly higher among current smokers at a Bonferroni adjusted p-value threshold (p<0.003). High sensitivity C-reactive protein was the most elevated biomarker among current smokers when compared to never smokers [GM ratio = 1.39 (95% CI: 1.23, 1.57); p <0.001]. Among former smokers, each pack-year of cigarettes smoked was associated with a 0.4% higher serum level of hsCRP [GM ratio = 1.004 (95% CI: 1.001, 1.006); p = 0.002] and each 5-year lapsed since quitting was associated with a 4% lower serum level of hsCRP [GM ratio = 0.96 (95% CI: 0.93, 0.99); p = 0.006]. However, we found no significant association of smoking intensity or burden with biomarkers of inflammation among current smokers. HsCRP appears to be the most sensitive biomarker of inflammation associated with cigarette smoking of those investigated, and could be a useful biomarker of smoking-related injury for the study and regulation of emerging tobacco products.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Article-2
ObjectType-Feature-1
content type line 23
Competing Interests: The authors have declared that no competing interests exist.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0184914