Immunohistochemical Analysis of Scarring Trachoma Indicates Infiltration by Natural Killer and Undefined CD45 Negative Cells

The phenotype and function of immune cells infiltrating the conjunctiva in scarring trachoma have yet to be fully characterized. We assessed tissue morphology and immunophenotype of cellular infiltrates found in trachomatous scarring compared to control participants. Clinical assessments and conjunc...

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Bibliographic Details
Published in:	PLoS neglected tropical diseases Vol. 10; no. 5; p. e0004734
Main Authors:	Hu, Victor H., Luthert, Philip J., Derrick, Tamsyn, Pullin, James, Weiss, Helen A., Massae, Patrick, Mtuy, Tara, Makupa, William, Essex, David, Mabey, David C. W., Bailey, Robin L., Holland, Martin J., Burton, Matthew J.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 24.05.2016 Public Library of Science (PLoS)
Subjects:	Adult Antigens, CD - analysis B-Lymphocytes - immunology Biology and Life Sciences Biomedical research Biopsy CD56 Antigen - analysis CD83 Antigen Chlamydia trachomatis Chlamydia trachomatis - immunology Cicatrix - immunology Cicatrix - pathology Collagen Conjunctiva - immunology Conjunctiva - pathology Dendritic cells Dendritic Cells - immunology Female Fibers Genotype & phenotype Humans Immunoglobulins - analysis Immunohistochemistry Immunophenotyping Infections Infiltration Inflammation Inflammation - immunology Killer cells Killer Cells, Natural - immunology Leukocyte Common Antigens - analysis Leukocyte Common Antigens - immunology Male Medicine and Health Sciences Membrane Glycoproteins - analysis Research and Analysis Methods Risk factors Staining and Labeling Studies Surgery T-Lymphocytes, Helper-Inducer - immunology Trachoma Trachoma - immunology Trachoma - parasitology Trichiasis - immunology Trichiasis - parasitology Trichiasis - pathology Tropical diseases
ISSN:	1935-2735, 1935-2727, 1935-2735
Online Access:	Get full text
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