Antagonists of PD-1 and PD-L1 in Cancer Treatment

The PD-1 pathway, comprising the immune cell co-receptor Programmed Death 1 (PD-1) and its ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC), mediates local immunosuppression in the tumor microenvironment. Drugs designed to block PD-1 or PD-L1 "release the brakes" on anti-tumor immunity and have de...

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Published in:Seminars in oncology Vol. 42; no. 4; pp. 587 - 600
Main Authors: Lipson, Evan J, Forde, Patrick M, Hammers, Hans-Joerg, Emens, Leisha A, Taube, Janis M, Topalian, Suzanne L
Format: Journal Article
Language:English
Published: United States 01.08.2015
Subjects:
Antineoplastic Agents - therapeutic use
B7-H1 Antigen - antagonists & inhibitors
Biomarkers, Tumor - metabolism
Humans
Immunosuppression - methods
Neoplasms - drug therapy
Neoplasms - metabolism
Programmed Cell Death 1 Receptor - antagonists & inhibitors
Tumor Microenvironment - drug effects
ISSN:1532-8708
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Abstract The PD-1 pathway, comprising the immune cell co-receptor Programmed Death 1 (PD-1) and its ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC), mediates local immunosuppression in the tumor microenvironment. Drugs designed to block PD-1 or PD-L1 "release the brakes" on anti-tumor immunity and have demonstrated clinical activity in several types of advanced cancers, validating this pathway as a target for cancer therapy. Two such drugs have recently been approved to treat melanoma and lung cancers, and regulatory approvals in first- and second-line settings for additional cancer types are anticipated. The manageable safety profile of PD-1/PD-L1 blocking drugs identifies them as suitable for outpatient administration and the development of combinatorial therapies. Ongoing studies aim to identify biomarkers to guide patient selection, which would further improve the risk:benefit ratio for these drugs.
AbstractList The PD-1 pathway, comprising the immune cell co-receptor Programmed Death 1 (PD-1) and its ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC), mediates local immunosuppression in the tumor microenvironment. Drugs designed to block PD-1 or PD-L1 "release the brakes" on anti-tumor immunity and have demonstrated clinical activity in several types of advanced cancers, validating this pathway as a target for cancer therapy. Two such drugs have recently been approved to treat melanoma and lung cancers, and regulatory approvals in first- and second-line settings for additional cancer types are anticipated. The manageable safety profile of PD-1/PD-L1 blocking drugs identifies them as suitable for outpatient administration and the development of combinatorial therapies. Ongoing studies aim to identify biomarkers to guide patient selection, which would further improve the risk:benefit ratio for these drugs.
Author Forde, Patrick M
Emens, Leisha A
Hammers, Hans-Joerg
Taube, Janis M
Lipson, Evan J
Topalian, Suzanne L
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  surname: Forde
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  surname: Hammers
  fullname: Hammers, Hans-Joerg
  organization: Department of Oncology, The Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD
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  givenname: Leisha A
  surname: Emens
  fullname: Emens, Leisha A
  organization: Department of Oncology, The Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD
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  givenname: Janis M
  surname: Taube
  fullname: Taube, Janis M
  organization: Department of Oncology, The Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Department of Dermatology, The Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Department of Pathology, The Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD
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  givenname: Suzanne L
  surname: Topalian
  fullname: Topalian, Suzanne L
  organization: Department of Surgery, The Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD
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References 25384885 - Oncology (Williston Park). 2014 Nov;28 Suppl 3:30-8
25428505 - Nature. 2014 Nov 27;515(7528):568-71
24608200 - Ann Oncol. 2014 Aug;25(8):1544-50
22437870 - Nat Rev Cancer. 2012 Apr;12(4):252-64
24590637 - J Clin Oncol. 2014 Apr 1;32(10):1020-30
23341518 - J Clin Oncol. 2013 Mar 1;31(7):860-7
24145345 - J Clin Oncol. 2013 Dec 1;31(34):4311-8
22679113 - J Natl Compr Canc Netw. 2012 Jun 1;10(6):690-3
22658127 - N Engl J Med. 2012 Jun 28;366(26):2443-54
23253225 - Expert Rev Anticancer Ther. 2012 Dec;12(12):1597-611
23288508 - Cancer Res. 2013 Mar 15;73(6):1733-41
21710841 - Oncology (Williston Park). 2011 Apr 30;25(5):427-8
25428503 - Nature. 2014 Nov 27;515(7528):558-62
25524312 - Clin Cancer Res. 2015 Feb 15;21(4):712-20
23724846 - N Engl J Med. 2013 Jul 11;369(2):134-44
24714771 - Clin Cancer Res. 2014 Oct 1;20(19):5064-74
12529460 - N Engl J Med. 2003 Jan 16;348(3):203-13
19825956 - Clin Cancer Res. 2009 Oct 15;15(20):6341-7
25452452 - J Clin Oncol. 2015 May 1;33(13):1430-7
20818862 - N Engl J Med. 2010 Jul 29;363(5):411-22
22658128 - N Engl J Med. 2012 Jun 28;366(26):2455-65
24658839 - Cancer Immunol Immunother. 2014 Jun;63(6):545-57
25409260 - N Engl J Med. 2014 Dec 4;371(23):2189-99
22186141 - Cancer Res. 2012 Feb 15;72(4):917-27
25428504 - Nature. 2014 Nov 27;515(7528):563-7
25482239 - N Engl J Med. 2015 Jan 22;372(4):311-9
23756627 - Breast Cancer Res Treat. 2013 Jun;139(3):667-76
25399552 - N Engl J Med. 2015 Jan 22;372(4):320-30
20628145 - Blood. 2010 Oct 28;116(17):3268-77
25034862 - Lancet. 2014 Sep 20;384(9948):1109-17
25358689 - Cancer Discov. 2015 Jan;5(1):43-51
17159987 - Nat Med. 2007 Jan;13(1):84-8
24831977 - Lancet Oncol. 2014 Jun;15(7):700-12
24842267 - Breast Cancer Res Treat. 2014 Jul;146(1):15-24
17360651 - Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3360-5
23169436 - Clin Cancer Res. 2013 Jan 15;19(2):462-8
23724867 - N Engl J Med. 2013 Jul 11;369(2):122-33
22461641 - Sci Transl Med. 2012 Mar 28;4(127):127ra37
22547591 - J Clin Oncol. 2012 Jun 10;30(17):2055-62
20516446 - J Clin Oncol. 2010 Jul 1;28(19):3167-75
References_xml – reference: 25399552 - N Engl J Med. 2015 Jan 22;372(4):320-30
– reference: 22437870 - Nat Rev Cancer. 2012 Apr;12(4):252-64
– reference: 25428503 - Nature. 2014 Nov 27;515(7528):558-62
– reference: 25428505 - Nature. 2014 Nov 27;515(7528):568-71
– reference: 20818862 - N Engl J Med. 2010 Jul 29;363(5):411-22
– reference: 20628145 - Blood. 2010 Oct 28;116(17):3268-77
– reference: 24714771 - Clin Cancer Res. 2014 Oct 1;20(19):5064-74
– reference: 24590637 - J Clin Oncol. 2014 Apr 1;32(10):1020-30
– reference: 25384885 - Oncology (Williston Park). 2014 Nov;28 Suppl 3:30-8
– reference: 25452452 - J Clin Oncol. 2015 May 1;33(13):1430-7
– reference: 22679113 - J Natl Compr Canc Netw. 2012 Jun 1;10(6):690-3
– reference: 23169436 - Clin Cancer Res. 2013 Jan 15;19(2):462-8
– reference: 23288508 - Cancer Res. 2013 Mar 15;73(6):1733-41
– reference: 23724867 - N Engl J Med. 2013 Jul 11;369(2):122-33
– reference: 25034862 - Lancet. 2014 Sep 20;384(9948):1109-17
– reference: 23253225 - Expert Rev Anticancer Ther. 2012 Dec;12(12):1597-611
– reference: 24608200 - Ann Oncol. 2014 Aug;25(8):1544-50
– reference: 25524312 - Clin Cancer Res. 2015 Feb 15;21(4):712-20
– reference: 23341518 - J Clin Oncol. 2013 Mar 1;31(7):860-7
– reference: 25482239 - N Engl J Med. 2015 Jan 22;372(4):311-9
– reference: 20516446 - J Clin Oncol. 2010 Jul 1;28(19):3167-75
– reference: 23756627 - Breast Cancer Res Treat. 2013 Jun;139(3):667-76
– reference: 24658839 - Cancer Immunol Immunother. 2014 Jun;63(6):545-57
– reference: 19825956 - Clin Cancer Res. 2009 Oct 15;15(20):6341-7
– reference: 22186141 - Cancer Res. 2012 Feb 15;72(4):917-27
– reference: 24145345 - J Clin Oncol. 2013 Dec 1;31(34):4311-8
– reference: 25428504 - Nature. 2014 Nov 27;515(7528):563-7
– reference: 22658127 - N Engl J Med. 2012 Jun 28;366(26):2443-54
– reference: 25409260 - N Engl J Med. 2014 Dec 4;371(23):2189-99
– reference: 17360651 - Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3360-5
– reference: 22547591 - J Clin Oncol. 2012 Jun 10;30(17):2055-62
– reference: 22461641 - Sci Transl Med. 2012 Mar 28;4(127):127ra37
– reference: 25358689 - Cancer Discov. 2015 Jan;5(1):43-51
– reference: 17159987 - Nat Med. 2007 Jan;13(1):84-8
– reference: 22658128 - N Engl J Med. 2012 Jun 28;366(26):2455-65
– reference: 23724846 - N Engl J Med. 2013 Jul 11;369(2):134-44
– reference: 24831977 - Lancet Oncol. 2014 Jun;15(7):700-12
– reference: 24842267 - Breast Cancer Res Treat. 2014 Jul;146(1):15-24
– reference: 21710841 - Oncology (Williston Park). 2011 Apr 30;25(5):427-8
– reference: 12529460 - N Engl J Med. 2003 Jan 16;348(3):203-13
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Snippet The PD-1 pathway, comprising the immune cell co-receptor Programmed Death 1 (PD-1) and its ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC), mediates local...
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SubjectTerms Antineoplastic Agents - therapeutic use
B7-H1 Antigen - antagonists & inhibitors
Biomarkers, Tumor - metabolism
Humans
Immunosuppression - methods
Neoplasms - drug therapy
Neoplasms - metabolism
Programmed Cell Death 1 Receptor - antagonists & inhibitors
Tumor Microenvironment - drug effects
Title Antagonists of PD-1 and PD-L1 in Cancer Treatment
URI https://www.ncbi.nlm.nih.gov/pubmed/26320063
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