Atrial fibrillation in heart failure: a comprehensive review

Chronic heart failure and atrial fibrillation are 2 major disorders that are closely linked. Their coexistence is associated with adverse prognosis. Both share several common predisposing conditions, but their interaction involves complex ultrastructural, electrophysiologic, and neurohormonal proces...

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Veröffentlicht in:	The American journal of medicine Jg. 123; H. 3; S. 198
Hauptverfasser:	Deedwania, Prakash C, Lardizabal, Joel A
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.03.2010
Schlagworte:	Anti-Arrhythmia Agents - therapeutic use Atrial Fibrillation - complications Atrial Fibrillation - diagnosis Atrial Fibrillation - therapy Catheter Ablation - methods Electrophysiologic Techniques, Cardiac - methods Heart Failure - complications Heart Failure - diagnosis Heart Failure - therapy Humans Prognosis
ISSN:	1555-7162, 1555-7162
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Beschreibung
Zusammenfassung:	Chronic heart failure and atrial fibrillation are 2 major disorders that are closely linked. Their coexistence is associated with adverse prognosis. Both share several common predisposing conditions, but their interaction involves complex ultrastructural, electrophysiologic, and neurohormonal processes that go beyond mere sharing of mutual risk factors. Rate control approach remains the standard therapy for atrial fibrillation in heart failure because current strategies at rhythm control have so far failed to positively impact mortality and morbidity. This is largely because of the shortcomings of current pharmacologic anti-arrhythmic agents. Surgical and catheter-based therapies are promising, but long-term data are lacking. The role of non-anti-arrhythmic therapeutic agents also is being explored. Further progress toward improved understanding the complex relationship between atrial fibrillation and heart failure should improve management strategies.
Bibliographie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ISSN:	1555-7162 1555-7162
DOI:	10.1016/j.amjmed.2009.06.033