Per- and poly-fluoroalkyl substances (PFAS) and female reproductive outcomes: PFAS elimination, endocrine-mediated effects, and disease
Per- and poly-fluoroalkyl substances (PFAS) are widespread environmental contaminants frequently detected in drinking water supplies worldwide that have been linked to a variety of adverse reproductive health outcomes in women. Compared to men, reproductive health effects in women are generally unde...
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| Veröffentlicht in: | Toxicology (Amsterdam) Jg. 465; S. 153031 |
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| Hauptverfasser: | , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
Ireland
Elsevier B.V
15.01.2022
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| ISSN: | 0300-483X, 1879-3185, 1879-3185 |
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| Abstract | Per- and poly-fluoroalkyl substances (PFAS) are widespread environmental contaminants frequently detected in drinking water supplies worldwide that have been linked to a variety of adverse reproductive health outcomes in women. Compared to men, reproductive health effects in women are generally understudied while global trends in female reproduction rates are declining. Many factors may contribute to the observed decline in female reproduction, one of which is environmental contaminant exposure. PFAS have been used in home, food storage, personal care and industrial products for decades. Despite the phase-out of some legacy PFAS due to their environmental persistence and adverse health effects, alternative, short-chain and legacy PFAS mixtures will continue to pollute water and air and adversely influence women’s health. Studies have shown that both long- and short-chain PFAS disrupt normal reproductive function in women through altering hormone secretion, menstrual cyclicity, and fertility. Here, we summarize the role of a variety of PFAS and PFAS mixtures in female reproductive tract dysfunction and disease. Since these chemicals may affect reproductive tissues directly or indirectly through endocrine disruption, the role of PFAS in breast, thyroid, and hypothalamic-pituitary-gonadal axis function are also discussed as the interplay between these tissues may be critical in understanding the long-term reproductive health effects of PFAS in women. A major research gap is the need for mechanism of action data – the targets for PFAS in the female reproductive and endocrine systems are not evident, but the effects are many. Given the global decline in female fecundity and the ability of PFAS to negatively impact female reproductive health, further studies are needed to examine effects on endocrine target tissues involved in the onset of reproductive disorders of women. |
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| AbstractList | Per- and poly-fluoroalkyl substances (PFAS) are widespread environmental contaminants frequently detected in drinking water supplies worldwide that have been linked to a variety of adverse reproductive health outcomes in women. Compared to men, reproductive health effects in women are generally understudied while global trends in female reproduction rates are declining. Many factors may contribute to the observed decline in female reproduction, one of which is environmental contaminant exposure. PFAS have been used in home, food storage, personal care and industrial products for decades. Despite the phase-out of some legacy PFAS due to their environmental persistence and adverse health effects, alternative, short-chain and legacy PFAS mixtures will continue to pollute water and air and adversely influence women's health. Studies have shown that both long- and short-chain PFAS disrupt normal reproductive function in women through altering hormone secretion, menstrual cyclicity, and fertility. Here, we summarize the role of a variety of PFAS and PFAS mixtures in female reproductive tract dysfunction and disease. Since these chemicals may affect reproductive tissues directly or indirectly through endocrine disruption, the role of PFAS in breast, thyroid, and hypothalamic-pituitary-gonadal axis function are also discussed as the interplay between these tissues may be critical in understanding the long-term reproductive health effects of PFAS in women. A major research gap is the need for mechanism of action data - the targets for PFAS in the female reproductive and endocrine systems are not evident, but the effects are many. Given the global decline in female fecundity and the ability of PFAS to negatively impact female reproductive health, further studies are needed to examine effects on endocrine target tissues involved in the onset of reproductive disorders of women.Per- and poly-fluoroalkyl substances (PFAS) are widespread environmental contaminants frequently detected in drinking water supplies worldwide that have been linked to a variety of adverse reproductive health outcomes in women. Compared to men, reproductive health effects in women are generally understudied while global trends in female reproduction rates are declining. Many factors may contribute to the observed decline in female reproduction, one of which is environmental contaminant exposure. PFAS have been used in home, food storage, personal care and industrial products for decades. Despite the phase-out of some legacy PFAS due to their environmental persistence and adverse health effects, alternative, short-chain and legacy PFAS mixtures will continue to pollute water and air and adversely influence women's health. Studies have shown that both long- and short-chain PFAS disrupt normal reproductive function in women through altering hormone secretion, menstrual cyclicity, and fertility. Here, we summarize the role of a variety of PFAS and PFAS mixtures in female reproductive tract dysfunction and disease. Since these chemicals may affect reproductive tissues directly or indirectly through endocrine disruption, the role of PFAS in breast, thyroid, and hypothalamic-pituitary-gonadal axis function are also discussed as the interplay between these tissues may be critical in understanding the long-term reproductive health effects of PFAS in women. A major research gap is the need for mechanism of action data - the targets for PFAS in the female reproductive and endocrine systems are not evident, but the effects are many. Given the global decline in female fecundity and the ability of PFAS to negatively impact female reproductive health, further studies are needed to examine effects on endocrine target tissues involved in the onset of reproductive disorders of women. Per- and poly-fluoroalkyl substances (PFAS) are widespread environmental contaminants frequently detected in drinking water supplies worldwide that have been linked to a variety of adverse reproductive health outcomes in women. Compared to men, reproductive health effects in women are generally understudied while global trends in female reproduction rates are declining. Many factors may contribute to the observed decline in female reproduction, one of which is environmental contaminant exposure. PFAS have been used in home, food storage, personal care and industrial products for decades. Despite the phase-out of some legacy PFAS due to their environmental persistence and adverse health effects, alternative, short-chain and legacy PFAS mixtures will continue to pollute water and air and adversely influence women’s health. Studies have shown that both long- and short-chain PFAS disrupt normal reproductive function in women through altering hormone secretion, menstrual cyclicity, and fertility. Here, we summarize the role of a variety of PFAS and PFAS mixtures in female reproductive tract dysfunction and disease. Since these chemicals may affect reproductive tissues directly or indirectly through endocrine disruption, the role of PFAS in breast, thyroid, and hypothalamic-pituitary-gonadal axis function are also discussed as the interplay between these tissues may be critical in understanding the long-term reproductive health effects of PFAS in women. A major research gap is the need for mechanism of action data – the targets for PFAS in the female reproductive and endocrine systems are not evident, but the effects are many. Given the global decline in female fecundity and the ability of PFAS to negatively impact female reproductive health, further studies are needed to examine effects on endocrine target tissues involved in the onset of reproductive disorders of women. AbstractPer- and poly-fluoroalkyl substances (PFAS) are widespread environmental contaminants frequently detected in drinking water supplies worldwide that have been linked to a variety of adverse reproductive health outcomes in women. Compared to men, reproductive health effects in women are generally understudied while global trends in female reproduction rates are declining. Many factors may contribute to the observed decline in female reproduction, one of which is environmental contaminant exposure. PFAS have been used in home, food storage, personal care and industrial products for decades. Despite the phase-out of some legacy PFAS due to their environmental persistence and adverse health effects, alternative, short-chain and legacy PFAS mixtures will continue to pollute water and air and adversely influence women’s health. Studies have shown that both long- and short-chain PFAS disrupt normal reproductive function in women through altering hormone secretion, menstrual cyclicity, and fertility. Here, we summarize the role of a variety of PFAS and PFAS mixtures in female reproductive tract dysfunction and disease. Since these chemicals may affect reproductive tissues directly or indirectly through endocrine disruption, the role of PFAS in breast, thyroid, and hypothalamic-pituitary-gonadal axis function are also discussed as the interplay between these tissues may be critical in understanding the long-term reproductive health effects of PFAS in women. A major research gap is the need for mechanism of action data – the targets for PFAS in the female reproductive and endocrine systems are not evident, but the effects are many. Given the global decline in female fecundity and the ability of PFAS to negatively impact female reproductive health, further studies are needed to examine effects on endocrine target tissues involved in the onset of reproductive disorders of women. |
| ArticleNumber | 153031 |
| Author | Rizvi, Imran Fenton, Suzanne E. Rickard, Brittany P. |
| AuthorAffiliation | b Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, North Carolina State University, Raleigh, NC 27599 USA a Curriculum in Toxicology & Environmental Medicine, UNC School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 USA c Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599 USA d Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 USA |
| AuthorAffiliation_xml | – name: a Curriculum in Toxicology & Environmental Medicine, UNC School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 USA – name: c Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599 USA – name: d Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 USA – name: b Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, North Carolina State University, Raleigh, NC 27599 USA |
| Author_xml | – sequence: 1 givenname: Brittany P. orcidid: 0000-0002-6112-1290 surname: Rickard fullname: Rickard, Brittany P. organization: Curriculum in Toxicology & Environmental Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA – sequence: 2 givenname: Imran surname: Rizvi fullname: Rizvi, Imran organization: Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, North Carolina State University, Raleigh, NC 27599, USA – sequence: 3 givenname: Suzanne E. orcidid: 0000-0002-8956-398X surname: Fenton fullname: Fenton, Suzanne E. email: fentonse@niehs.nih.gov organization: Division of the National Toxicology Program, National Institute of Environmental Health Sciences, 111 TW Alexander Dr., Rm E121A, Research Triangle Park, NC 27709, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34774661$$D View this record in MEDLINE/PubMed |
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| Keywords | CDC EDC ADONA PFNA E2 PFAS PFBA TPO-Ab FSH HBM-I ERβ NIOSH ERα TSH Endocrine disruption PFOSA PCOS Environmental contaminants Me-PFOSA-AcOH PFUdA SWAN AFFF HPGA DDE TTP PFHxA OC DDT PFDA GnRH BMI T3 T4 PFBS Female reproduction PFHxS PFDOA PFHpA Et-PFOSA-AcOH PFOA FAI HFPO-DA DES EPA NHANES LH SHBG PFHpS PFOS Perfluorobutanoic acid Perfluorododecanoic acid Study of Women’s Health Across the Nation Perfluorodecanoic acid endocrine disruption Perfluorobutane sulfonate Body mass index Luteinizing hormone Diethylstilbestrol Free androgen index Perfluoroundecanoic acid Estrogen receptor-α Time to pregnancy Estrogen receptor-β Perfluorohexane sulfonate Hypothalamic-pituitary-gonadal axis Thyroid-stimulating hormone United States National Health and Nutrition Examination Survey National Institute for Occupational Safety and Health Perfluorohexanoic acid Thyroid peroxidase antibody Gonadotropin-releasing hormone Aqueous film forming foam Environmental Protection Agency environmental contaminants Sex hormone-binding globulin Perfluoroheptanoic acid Estradiol Perfluorooctane sulfonamide female reproduction Perfluorooctanoic acid Centers for Disease Control and Prevention Perfluoroheptane sulfonate Thyroxine Ammonium perfluoro(2-methyl-3-oxahexanoate) Polycystic ovarian syndrome Perfluorooctane sulfonate Triiodothyronine Dichlorodiphenyltrichloroethane 2-(N-ethylperfluorooctane sulfonamido) acetic acid Ammonium 4,8-dioxa-3H-perfluorononanoate Follicle-stimulating hormone Diphenyldichloroethene Per- and poly-fluoroalkyl substances Human Biomonitoring-I Oral contraceptive 2-(N-methyl-perfluorooctane sulfonamido) acetic acid Perfluorononanoic acid Endocrine-disrupting compound |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 Suzanne Fenton: Conceptualization; Data curation; Supervision; Figure 1; Writing – review & editing. Imran Rizvi: Funding acquisition; Supervision; Writing – review & editing. Brittany Rickard: Conceptualization; Data curation; Visualization; Developed table and Figure 2; Writing – original draft; Writing – review & editing. Paper tasks |
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| Snippet | Per- and poly-fluoroalkyl substances (PFAS) are widespread environmental contaminants frequently detected in drinking water supplies worldwide that have been... AbstractPer- and poly-fluoroalkyl substances (PFAS) are widespread environmental contaminants frequently detected in drinking water supplies worldwide that... |
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| SubjectTerms | air breasts Emergency Endocrine disruption Endocrine Disruptors - adverse effects Endocrine System Diseases - chemically induced Endocrine System Diseases - metabolism Endocrine System Diseases - physiopathology Environmental contaminants Environmental Exposure - adverse effects environmental fate Environmental Pollutants - adverse effects fecundity Female Female reproduction female reproductive system females Fertility - drug effects food storage hormone secretion Humans Hydrocarbons, Fluorinated - adverse effects Infertility, Female - chemically induced Infertility, Female - metabolism Infertility, Female - physiopathology mechanism of action Menstrual Cycle - drug effects periodicity PFAS pollution Pregnancy Pregnancy Complications - chemically induced Pregnancy Complications - metabolism Pregnancy Complications - physiopathology Prognosis Reproduction - drug effects Risk Assessment Risk Factors toxicology |
| Title | Per- and poly-fluoroalkyl substances (PFAS) and female reproductive outcomes: PFAS elimination, endocrine-mediated effects, and disease |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S0300483X2100353X https://www.clinicalkey.es/playcontent/1-s2.0-S0300483X2100353X https://dx.doi.org/10.1016/j.tox.2021.153031 https://www.ncbi.nlm.nih.gov/pubmed/34774661 https://www.proquest.com/docview/2597802858 https://www.proquest.com/docview/2636509972 https://pubmed.ncbi.nlm.nih.gov/PMC8743032 |
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