A comparative review of aging and B cell function in mice and humans

•B cell generation in bone marrow declines with age in mice but may be maintained in humans.•Shifts in naïve and antigen-experienced peripheral B cell subsets are now well documented in both mice and humans, although some controversies still exist in humans.•Antibody responses to both T cell-depende...

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Bibliographic Details
Published in:	Current opinion in immunology Vol. 25; no. 4; pp. 504 - 510
Main Authors:	Scholz, Jean L, Diaz, Alain, Riley, Richard L, Cancro, Michael P, Frasca, Daniela
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.08.2013
Subjects:	adults Aging Allergy and Immunology animal models Animals B-Lymphocytes - cytology B-Lymphocytes - immunology Cell Differentiation Homeostasis Humans humoral immunity immune response immune system Immunity, Humoral longevity Mice
ISSN:	0952-7915, 1879-0372, 1879-0372
Online Access:	Get full text
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