Genomic landscape of adult testicular germ cell tumours in the 100,000 Genomes Project

Testicular germ cell tumours (TGCT), which comprise seminoma and non-seminoma subtypes, are the most common cancers in young men. In this study, we present a comprehensive whole genome sequencing analysis of adult TGCTs. Leveraging samples from participants recruited via the UK National Health Servi...

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Bibliographic Details
Published in:	Nature communications Vol. 15; no. 1; pp. 9247 - 13
Main Authors:	Ní Leathlobhair, Máire, Frangou, Anna, Kinnersley, Ben, Cornish, Alex J., Chubb, Daniel, Lakatos, Eszter, Arumugam, Prabhu, Gruber, Andreas J., Law, Philip, Tapinos, Avraam, Jakobsdottir, G. Maria, Peneva, Iliana, Sahli, Atef, Smyth, Evie M., Ball, Richard Y., Sylva, Rushan, Benes, Ksenija, Stark, Dan, Young, Robin J., Lee, Alexander T. J., Wolverson, Vincent, Houlston, Richard S., Sosinsky, Alona, Protheroe, Andrew, Murray, Matthew J., Wedge, David C., Verrill, Clare
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 26.10.2024 Nature Publishing Group Nature Portfolio
Subjects:	45 45/23 631/114 631/67/1836 631/67/580 631/67/68 631/67/69 Adult Antigens Cancer Copy number Data analysis Divergence DNA Copy Number Variations - genetics Gene sequencing Genome, Human Genomes Genomic analysis Genomics Genomics - methods Histocompatibility antigen HLA Humanities and Social Sciences Humans Leukocytes Male Medical Genetics and Genomics Medicinsk genetik och genomik multidisciplinary Mutation Neoplasms, Germ Cell and Embryonal - genetics Neoplasms, Germ Cell and Embryonal - pathology Pathogenesis Science Science (multidisciplinary) Seminoma Seminoma - genetics Seminoma - pathology Subgroups Testes Testicular Neoplasms - genetics Testicular Neoplasms - pathology Tumors Whole Genome Sequencing United Kingdom > UK England
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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