ANGPTL3 Deficiency and Protection Against Coronary Artery Disease

Familial combined hypolipidemia, a Mendelian condition characterized by substantial reductions in all 3 major lipid fractions, is caused by mutations that inactivate the gene angiopoietin-like 3 (ANGPTL3). Whether ANGPTL3 deficiency reduces risk of coronary artery disease (CAD) is unknown. The study...

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Veröffentlicht in:	Journal of the American College of Cardiology Jg. 69; H. 16; S. 2054
Hauptverfasser:	Stitziel, Nathan O, Khera, Amit V, Wang, Xiao, Bierhals, Andrew J, Vourakis, A Christina, Sperry, Alexandra E, Natarajan, Pradeep, Klarin, Derek, Emdin, Connor A, Zekavat, Seyedeh M, Nomura, Akihiro, Erdmann, Jeanette, Schunkert, Heribert, Samani, Nilesh J, Kraus, William E, Shah, Svati H, Yu, Bing, Boerwinkle, Eric, Rader, Daniel J, Gupta, Namrata, Frossard, Philippe M, Rasheed, Asif, Danesh, John, Lander, Eric S, Gabriel, Stacey, Saleheen, Danish, Musunuru, Kiran, Kathiresan, Sekar
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 25.04.2017
Schlagworte:	Adult Angiopoietin-Like Protein 3 Angiopoietin-like Proteins Angiopoietins - blood Angiopoietins - deficiency Angiopoietins - genetics Animals Atherosclerosis - genetics Case-Control Studies Coronary Artery Disease - genetics Female Humans Lipids - blood Male Mice, Inbred C57BL Mice, Knockout Middle Aged Mutation, Missense Myocardial Infarction - blood Risk Factors human genetics loss-of-function mutations myocardial infarction
ISSN:	1558-3597, 1558-3597
Online-Zugang:	Weitere Angaben
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