Lactate dehydrogenase levels predict coronavirus disease 2019 (COVID-19) severity and mortality: A pooled analysis

Coronavirus disease 2019 (COVID-19) infection has now reached a pandemic state, affecting more than a million patients worldwide. Predictors of disease outcomes in these patients need to be urgently assessed to decrease morbidity and societal burden. Lactate dehydrogenase (LDH) has been associated w...

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Bibliographic Details
Published in:The American journal of emergency medicine Vol. 38; no. 9; pp. 1722 - 1726
Main Authors: Henry, Brandon Michael, Aggarwal, Gaurav, Wong, Johnny, Benoit, Stefanie, Vikse, Jens, Plebani, Mario, Lippi, Giuseppe
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01.09.2020
Elsevier Limited
Subjects:
Betacoronavirus
Biomarkers - blood
C-Reactive Protein - metabolism
Coronavirus
Coronavirus Infections - enzymology
Coronavirus Infections - epidemiology
Coronaviruses
COVID-19
Dehydrogenase
Emergency
Emergency medical care
Global Health
Humans
L-Lactate dehydrogenase
L-Lactate Dehydrogenase - blood
Lactate dehydrogenase
Lactic acid
Morbidity
Mortality
Pandemics
Pneumonia, Viral - enzymology
Pneumonia, Viral - epidemiology
SARS-CoV-2
Severity of Illness Index
Survival Rate - trends
Viral infections
China
COVID-19
Lactate dehydrogenase
Coronavirus
ISSN:0735-6757, 1532-8171, 1532-8171
Online Access:Get full text
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Summary:Coronavirus disease 2019 (COVID-19) infection has now reached a pandemic state, affecting more than a million patients worldwide. Predictors of disease outcomes in these patients need to be urgently assessed to decrease morbidity and societal burden. Lactate dehydrogenase (LDH) has been associated with worse outcomes in patients with viral infections. In this pooled analysis of 9 published studies (n = 1532 COVID-19 patients), we evaluated the association between elevated LDH levels measured at earliest time point in hospitalization and disease outcomes in patients with COVID-19. Elevated LDH levels were associated with a ~6-fold increase in odds of developing severe disease and a ~16-fold increase in odds of mortality in patients with COVID-19. Larger studies are needed to confirm these findings.
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ISSN:0735-6757
1532-8171
1532-8171
DOI:10.1016/j.ajem.2020.05.073