Fluoride bioavailability in saliva and plaque

Background Different fluoride formulations may have different effects on caries prevention. It was the aim of this clinical study to assess the fluoride content, provided by NaF compared to amine fluoride, in saliva and plaque. Methods Eight trained volunteers brushed their teeth in the morning for...

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Published in:BMC oral health Vol. 12; no. 1; p. 3
Main Authors: Naumova, Ella A, Kuehnl, Phillip, Hertenstein, Philipp, Markovic, Ljubisa, Jordan, Rainer A, Gaengler, Peter, Arnold, Wolfgang H
Format: Journal Article
Language:English
Published: London BioMed Central 09.01.2012
BioMed Central Ltd
Springer Nature B.V
BMC
Subjects:
Adult
Aged
Amines - pharmacokinetics
Biological Availability
Cariostatic Agents - pharmacokinetics
Cross-Over Studies
Dental care
Dental caries
Dental Plaque - metabolism
Dentifrices - pharmacokinetics
Dentistry
Drinking water
Enamel
Female
Fluoridation
Fluorides
Fluorides - pharmacokinetics
Health aspects
Humans
Hygiene
Ion-Selective Electrodes
Male
Medicine
Middle Aged
Oral and Maxillofacial Surgery
Research Article
Saliva - metabolism
Sodium Fluoride - pharmacokinetics
Statistics, Nonparametric
Tin Fluorides - pharmacokinetics
Toothbrushing
Young Adult
Germany
Tooth Brushing
Fluoride
Fluoride Concentration
Dental Plaque
Enamel Surface
ISSN:1472-6831, 1472-6831
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Summary:Background Different fluoride formulations may have different effects on caries prevention. It was the aim of this clinical study to assess the fluoride content, provided by NaF compared to amine fluoride, in saliva and plaque. Methods Eight trained volunteers brushed their teeth in the morning for 3 minutes with either NaF or amine fluoride, and saliva and 3-day-plaque-regrowth was collected at 5 time intervals during 6 hours after tooth brushing. The amount of collected saliva and plaque was measured, and the fluoride content was analysed using a fluoride sensitive electrode. All subjects repeated all study cycles 5 times, and 3 cycles per subject underwent statistical analysis using the Wilcoxon-Mann-Whitney test. Results Immediately after brushing the fluoride concentration in saliva increased rapidly and dropped to the baseline level after 360 minutes. No difference was found between NaF and amine fluoride. All plaque fluoride levels were elevated after 30 minutes until 120 minutes after tooth brushing, and decreasing after 360 minutes to baseline. According to the highly individual profile of fluoride in saliva and plaque, both levels of bioavailability correlated for the first 30 minutes, and the fluoride content of saliva and plaque was back to baseline after 6 hours. Conclusions Fluoride levels in saliva and plaque are interindividually highly variable. However, no significant difference in bioavailability between NaF and amine fluoride, in saliva, or in plaque was found.
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ISSN:1472-6831
1472-6831
DOI:10.1186/1472-6831-12-3