Mindfulness meditation and the immune system: a systematic review of randomized controlled trials

Mindfulness meditation represents a mental training framework for cultivating the state of mindful awareness in daily life. Recently, there has been a surge of interest in how mindfulness meditation improves human health and well‐being. Although studies have shown that mindfulness meditation can imp...

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Vydáno v:Annals of the New York Academy of Sciences Ročník 1373; číslo 1; s. 13 - 24
Hlavní autoři: Black, David S., Slavich, George M.
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Blackwell Publishing Ltd 01.06.2016
Wiley Subscription Services, Inc
Témata:
Aging
Awareness - physiology
biology
Clinical trials
cytokines
disease
Gene expression
health
Heterogeneity
Humans
Hypnosis
Immune system
Immune System - physiology
Immunity, Cellular
inflammation
intervention
Meditation
Mindfulness
Randomized Controlled Trials as Topic
Stress, Psychological - immunology
Stress, Psychological - therapy
biology
disease
inflammation
meditation
mindfulness
immune system
health
cytokines
aging
intervention
ISSN:0077-8923, 1749-6632, 1749-6632
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Shrnutí:Mindfulness meditation represents a mental training framework for cultivating the state of mindful awareness in daily life. Recently, there has been a surge of interest in how mindfulness meditation improves human health and well‐being. Although studies have shown that mindfulness meditation can improve self‐reported measures of disease symptomatology, the effect that mindfulness meditation has on biological mechanisms underlying human aging and disease is less clear. To address this issue, we conducted the first comprehensive review of randomized controlled trials examining the effects of mindfulness meditation on immune system parameters, with a specific focus on five outcomes: (1) circulating and stimulated inflammatory proteins, (2) cellular transcription factors and gene expression, (3) immune cell count, (4) immune cell aging, and (5) antibody response. This analysis revealed substantial heterogeneity across studies with respect to patient population, study design, and assay procedures. The findings suggest possible effects of mindfulness meditation on specific markers of inflammation, cell‐mediated immunity, and biological aging, but these results are tentative and require further replication. On the basis of this analysis, we describe the limitations of existing work and suggest possible avenues for future research. Mindfulness meditation may be salutogenic for immune system dynamics, but additional work is needed to examine these effects.
Bibliografie:Biodemography and Population Health - No. P30 AG017265
ArticleID:NYAS12998
istex:F166850D4B49EBCEEDCFD7E3850A27179C0EA0CF
ark:/67375/WNG-H2MTMXFX-D
National Institute of Mental Health - No. K08 MH103443
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
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ISSN:0077-8923
1749-6632
1749-6632
DOI:10.1111/nyas.12998