New tools for automated high-resolution cryo-EM structure determination in RELION-3

Here, we describe the third major release of RELION. CPU-based vector acceleration has been added in addition to GPU support, which provides flexibility in use of resources and avoids memory limitations. Reference-free autopicking with Laplacian-of-Gaussian filtering and execution of jobs from pytho...

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Veröffentlicht in:	eLife Jg. 7
Hauptverfasser:	Zivanov, Jasenko, Nakane, Takanori, Forsberg, Björn O, Kimanius, Dari, Hagen, Wim JH, Lindahl, Erik, Scheres, Sjors HW
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England eLife Sciences Publications Ltd 09.11.2018 eLife Sciences Publications, Ltd
Schlagworte:	Automation Automation, Laboratory - methods Bayesian analysis Biochemistry towards Bioinformatics biokemi med inriktning mot bioinformatik Classification Cryo-EM Cryoelectron Microscopy - methods Datasets Fourier transforms Image Processing, Computer-Assisted - methods Laboratories Microscopy Molecular biology Sensors single-particle analysis Software Structural Biology and Molecular Biophysics Tools and Resources Heidelberg Germany Sweden Stockholm Sweden United States > US Germany structural biology none software molecular biophysics Cryo-EM single-particle analysis
ISSN:	2050-084X, 2050-084X
Online-Zugang:	Volltext
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