The genomic landscape of core-binding factor acute myeloid leukemias

Lars Bullinger, Jinghui Zhang, Jeffery Klco, James Downing and colleagues report a detailed genomic analysis of pediatric and adult core-binding factor acute myeloid leukemias (CBF-AMLs). They identify recurrent mutations in CCND2 , MGA , DHX15 and ZBTB7A and highlight dramatic differences in the la...

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Bibliographic Details
Published in:	Nature genetics Vol. 48; no. 12; pp. 1551 - 1556
Main Authors:	Faber, Zachary J, Chen, Xiang, Gedman, Amanda Larson, Boggs, Kristy, Cheng, Jinjun, Ma, Jing, Radtke, Ina, Chao, Jyh-Rong, Walsh, Michael P, Song, Guangchun, Andersson, Anna K, Dang, Jinjun, Dong, Li, Liu, Yu, Huether, Robert, Cai, Zhongling, Mulder, Heather, Wu, Gang, Edmonson, Michael, Rusch, Michael, Qu, Chunxu, Li, Yongjin, Vadodaria, Bhavin, Wang, Jianmin, Hedlund, Erin, Cao, Xueyuan, Yergeau, Donald, Nakitandwe, Joy, Pounds, Stanley B, Shurtleff, Sheila, Fulton, Robert S, Fulton, Lucinda L, Easton, John, Parganas, Evan, Pui, Ching-Hon, Rubnitz, Jeffrey E, Ding, Li, Mardis, Elaine R, Wilson, Richard K, Gruber, Tanja A, Mullighan, Charles G, Schlenk, Richard F, Paschka, Peter, Döhner, Konstanze, Döhner, Hartmut, Bullinger, Lars, Zhang, Jinghui, Klco, Jeffery M, Downing, James R
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.12.2016 Nature Publishing Group
Subjects:	631/208/514/1948 631/67/1990/283/1897 Adult Agriculture Analysis Animal Genetics and Genomics Bioinformatics Biomarkers, Tumor - genetics Biomedicine Biosynthesis Cancer Cancer genetics Cancer Research Child Children & youth Clinical Medicine Core Binding Factors - genetics Epigenetic inheritance Gene Function Genetic aspects Genomes Genomics Genomics - methods Hematologi Hematology Human Genetics Humans Klinisk medicin Laboratories letter Leukemia Leukemia, Myeloid, Acute - genetics Medical and Health Sciences Medicin och hälsovetenskap Mutation Mutation - genetics Oncogene Proteins, Fusion - genetics Pediatrics Proteins Spectrum analysis Studies Transcription (Genetics) Transcription factors
ISSN:	1061-4036, 1546-1718, 1546-1718
Online Access:	Get full text
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