Infantile Fibrosarcoma With NTRK3-ETV6 Fusion Successfully Treated With the Tropomyosin-Related Kinase Inhibitor LOXO-101

Infantile fibrosarcoma (IFS) is a rare pediatric cancer typically presenting in the first 2 years of life. Surgical resection is usually curative and chemotherapy is active against gross residual disease. However, when recurrences occur, therapeutic options are limited. We report a case of refractor...

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Veröffentlicht in:	Pediatric blood & cancer Jg. 63; H. 8; S. 1468 - 1470
Hauptverfasser:	Nagasubramanian, Ramamoorthy, Wei, Julie, Gordon, Paul, Rastatter, Jeff C., Cox, Michael C., Pappo, Alberto
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Blackwell Publishing Ltd 01.08.2016 Wiley Subscription Services, Inc John Wiley and Sons Inc
Schlagworte:	Brief Report Brief Reports ETS Translocation Variant 6 Protein ETV6-NTRK3 Female Fibrosarcoma - diagnostic imaging Fibrosarcoma - drug therapy Fibrosarcoma - genetics Fibrosarcoma - surgery gene fusion Genes Hematology Humans Infant infantile fibrosarcoma Kinases LOXO-101 Magnetic Resonance Imaging Oncology Pediatrics Proto-Oncogene Proteins c-ets - genetics Pyrazoles - therapeutic use Pyrimidines - therapeutic use Receptor, trkC - antagonists & inhibitors Receptor, trkC - genetics Recombinant Fusion Proteins - genetics Repressor Proteins - genetics tropomyosin-related kinase (TRK) LOXO-101 ETV6-NTRK3 infantile fibrosarcoma tropomyosin-related kinase (TRK) gene fusion
ISSN:	1545-5009, 1545-5017, 1545-5017
Online-Zugang:	Volltext
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