Infantile Fibrosarcoma With NTRK3-ETV6 Fusion Successfully Treated With the Tropomyosin-Related Kinase Inhibitor LOXO-101

Infantile fibrosarcoma (IFS) is a rare pediatric cancer typically presenting in the first 2 years of life. Surgical resection is usually curative and chemotherapy is active against gross residual disease. However, when recurrences occur, therapeutic options are limited. We report a case of refractor...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Pediatric blood & cancer Ročník 63; číslo 8; s. 1468 - 1470
Hlavní autoři:	Nagasubramanian, Ramamoorthy, Wei, Julie, Gordon, Paul, Rastatter, Jeff C., Cox, Michael C., Pappo, Alberto
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Blackwell Publishing Ltd 01.08.2016 Wiley Subscription Services, Inc John Wiley and Sons Inc
Témata:	Brief Report Brief Reports ETS Translocation Variant 6 Protein ETV6-NTRK3 Female Fibrosarcoma - diagnostic imaging Fibrosarcoma - drug therapy Fibrosarcoma - genetics Fibrosarcoma - surgery gene fusion Genes Hematology Humans Infant infantile fibrosarcoma Kinases LOXO-101 Magnetic Resonance Imaging Oncology Pediatrics Proto-Oncogene Proteins c-ets - genetics Pyrazoles - therapeutic use Pyrimidines - therapeutic use Receptor, trkC - antagonists & inhibitors Receptor, trkC - genetics Recombinant Fusion Proteins - genetics Repressor Proteins - genetics tropomyosin-related kinase (TRK) LOXO-101 ETV6-NTRK3 infantile fibrosarcoma tropomyosin-related kinase (TRK) gene fusion
ISSN:	1545-5009, 1545-5017, 1545-5017
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Abstract	Infantile fibrosarcoma (IFS) is a rare pediatric cancer typically presenting in the first 2 years of life. Surgical resection is usually curative and chemotherapy is active against gross residual disease. However, when recurrences occur, therapeutic options are limited. We report a case of refractory IFS with constitutive activation of the tropomyosin‐related kinase (TRK) signaling pathway from an ETS variant gene 6–neurotrophin 3 receptor gene (ETV6–NTRK3) gene fusion. The patient enrolled in a pediatric Phase 1 trial of LOXO‐101, an experimental, highly selective inhibitor of TRK. The patient experienced a rapid, radiographic response, demonstrating the potential for LOXO‐101 to provide benefit for IFS harboring NTRK gene fusions.
AbstractList	Infantile fibrosarcoma (IFS) is a rare pediatric cancer typically presenting in the first 2 years of life. Surgical resection is usually curative and chemotherapy is active against gross residual disease. However, when recurrences occur, therapeutic options are limited. We report a case of refractory IFS with constitutive activation of the tropomyosin-related kinase (TRK) signaling pathway from an ETS variant gene 6-neurotrophin 3 receptor gene (ETV6-NTRK3) gene fusion. The patient enrolled in a pediatric Phase 1 trial of LOXO-101, an experimental, highly selective inhibitor of TRK. The patient experienced a rapid, radiographic response, demonstrating the potential for LOXO-101 to provide benefit for IFS harboring NTRK gene fusions.Infantile fibrosarcoma (IFS) is a rare pediatric cancer typically presenting in the first 2 years of life. Surgical resection is usually curative and chemotherapy is active against gross residual disease. However, when recurrences occur, therapeutic options are limited. We report a case of refractory IFS with constitutive activation of the tropomyosin-related kinase (TRK) signaling pathway from an ETS variant gene 6-neurotrophin 3 receptor gene (ETV6-NTRK3) gene fusion. The patient enrolled in a pediatric Phase 1 trial of LOXO-101, an experimental, highly selective inhibitor of TRK. The patient experienced a rapid, radiographic response, demonstrating the potential for LOXO-101 to provide benefit for IFS harboring NTRK gene fusions. Infantile fibrosarcoma (IFS) is a rare pediatric cancer typically presenting in the first 2 years of life. Surgical resection is usually curative and chemotherapy is active against gross residual disease. However, when recurrences occur, therapeutic options are limited. We report a case of refractory IFS with constitutive activation of the tropomyosin‐related kinase (TRK) signaling pathway from an ETS variant gene 6–neurotrophin 3 receptor gene (ETV6–NTRK3) gene fusion. The patient enrolled in a pediatric Phase 1 trial of LOXO‐101, an experimental, highly selective inhibitor of TRK. The patient experienced a rapid, radiographic response, demonstrating the potential for LOXO‐101 to provide benefit for IFS harboring NTRK gene fusions.
Author	Cox, Michael C. Wei, Julie Gordon, Paul Rastatter, Jeff C. Nagasubramanian, Ramamoorthy Pappo, Alberto
AuthorAffiliation	1 Nemours Children's Hospital Orlando Florida 4 St. Jude Children's Research Hospital Memphis Tennessee 3 Loxo Oncology Inc South San Francisco California 2 Department of Otolaryngology – Head and Neck Surgery Northwestern University Feinberg School of Medicine Chicago Illinois
AuthorAffiliation_xml	– name: 1 Nemours Children's Hospital Orlando Florida – name: 3 Loxo Oncology Inc South San Francisco California – name: 2 Department of Otolaryngology – Head and Neck Surgery Northwestern University Feinberg School of Medicine Chicago Illinois – name: 4 St. Jude Children's Research Hospital Memphis Tennessee
Author_xml	– sequence: 1 givenname: Ramamoorthy surname: Nagasubramanian fullname: Nagasubramanian, Ramamoorthy email: Correspondence to: Ramamoorthy Nagasubramanian, Nemours Children's Hospital, 13535 Nemours Parkway, Orlando, FL 32827., rnagasub@nemours.org organization: Nemours Children's Hospital, Florida, Orlando – sequence: 2 givenname: Julie surname: Wei fullname: Wei, Julie organization: Nemours Children's Hospital, Florida, Orlando – sequence: 3 givenname: Paul surname: Gordon fullname: Gordon, Paul organization: Nemours Children's Hospital, Florida, Orlando – sequence: 4 givenname: Jeff C. surname: Rastatter fullname: Rastatter, Jeff C. organization: Department of Otolaryngology - Head and Neck Surgery, Northwestern University Feinberg School of Medicine, Illinois, Chicago – sequence: 5 givenname: Michael C. surname: Cox fullname: Cox, Michael C. organization: Loxo Oncology Inc, California, South San Francisco – sequence: 6 givenname: Alberto surname: Pappo fullname: Pappo, Alberto organization: St. Jude Children's Research Hospital, Tennessee, Memphis
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/27093299$$D View this record in MEDLINE/PubMed
BookMark	eNqNkktv1DAUhSNURB-w4A-gSGxgkdaP2E42SDDqlFGHmWoYKDvLdhzGbWIPdgLk3-N2HoIKJFa2fL9zdH3vOU4OrLM6SZ5DcAoBQGdrqU4RBYg-So4gyUlGAGQH-zsoD5PjEG4iSgEpniSHiIESo7I8SoaJrYXtTKPTsZHeBeGVa0V6bbpVOlsuLnF2vvxM03EfjLPpx14pHULdN82QLr0Wna42bLfS8cGtXTu4YGy20M198dJYEXQ6sSsjTed8Op1_mWcQwKfJ41o0QT_bnifJp_H5cvQ-m84vJqO300xRktOsZFjkFEqUC4krJBXSkAHJqppipFQllMixVLUqAIV1XhGcl4hWNal0Keta4pPkzcZ33ctWV0rbzouGr71phR-4E4b_WbFmxb-675wAlqMcR4NXWwPvvvU6dLw1QemmEVa7PnBYgIJCith_oKwsURw9AxF9-QC9cb23cRJ3VIEYyYsyUi9-b37f9W6BETjbACruLnhdc2U60cVdxb-YhkPA7yLCY0T4fUSi4vUDxc70b-zW_UcMyPBvkF-9G-0U2UZhQqd_7hXC33LKMCP8enbBx-ADLBZXM07wL2fj2dA
CitedBy_id	crossref_primary_10_1002_pbc_26813 crossref_primary_10_1038_s41379_018_0118_3 crossref_primary_10_1097_PAS_0000000000000911 crossref_primary_10_1016_S1470_2045_19_30691_6 crossref_primary_10_1002_ijc_33723 crossref_primary_10_1016_j_pharmthera_2017_02_006 crossref_primary_10_1016_j_ijporl_2018_09_031 crossref_primary_10_1002_hed_25536 crossref_primary_10_1111_his_13981 crossref_primary_10_1038_s41419_024_06752_0 crossref_primary_10_1097_PAS_0000000000001203 crossref_primary_10_1007_s12105_017_0855_5 crossref_primary_10_1016_j_semcancer_2020_07_009 crossref_primary_10_1016_j_ymthe_2018_10_022 crossref_primary_10_1111_jpc_70039 crossref_primary_10_1007_s11523_018_0590_1 crossref_primary_10_1007_s00441_017_2761_2 crossref_primary_10_1111_cup_13926 crossref_primary_10_1002_pbc_26925 crossref_primary_10_1007_s00428_018_2415_0 crossref_primary_10_1002_gcc_22671 crossref_primary_10_1016_j_path_2018_10_009 crossref_primary_10_1016_j_cancergen_2021_12_002 crossref_primary_10_1016_j_cell_2019_02_049 crossref_primary_10_1097_MPH_0000000000001013 crossref_primary_10_3390_ijms19123784 crossref_primary_10_1007_s00401_022_02405_8 crossref_primary_10_1002_lio2_169 crossref_primary_10_1007_s11912_019_0761_y crossref_primary_10_1093_labmed_lmz102 crossref_primary_10_1016_j_jmoldx_2018_10_003 crossref_primary_10_1038_modpathol_2017_127 crossref_primary_10_1038_s41585_024_00993_6 crossref_primary_10_1155_2020_6716742 crossref_primary_10_3390_ijms19030739 crossref_primary_10_1016_j_jpedsurg_2019_10_051 crossref_primary_10_1097_PAS_0000000000001074 crossref_primary_10_1007_s00761_019_00693_6 crossref_primary_10_1016_j_bbcan_2020_188389 crossref_primary_10_1177_1093526617712639 crossref_primary_10_1055_s_0045_1809888 crossref_primary_10_3389_fcell_2023_1284428 crossref_primary_10_1080_14737140_2019_1538796 crossref_primary_10_1016_j_joms_2019_01_002 crossref_primary_10_1177_10935266221114017 crossref_primary_10_1111_ped_13704 crossref_primary_10_1053_j_sempedsurg_2016_09_012 crossref_primary_10_1158_2159_8290_CD_17_0507 crossref_primary_10_1016_j_gendis_2025_101536 crossref_primary_10_1097_PAS_0000000000000938 crossref_primary_10_1080_17512433_2019_1661775 crossref_primary_10_1097_PAI_0000000000001116 crossref_primary_10_1097_ANC_0000000000000440 crossref_primary_10_1093_annonc_mdz191 crossref_primary_10_1080_13543776_2017_1297797 crossref_primary_10_1038_s41375_019_0576_8 crossref_primary_10_1097_PAS_0000000000001062 crossref_primary_10_1016_j_jtho_2018_12_003 crossref_primary_10_3892_br_2023_1630 crossref_primary_10_1172_JCI120787 crossref_primary_10_1016_j_ejca_2020_06_028 crossref_primary_10_1016_j_jmoldx_2019_03_008 crossref_primary_10_1155_2020_5903863 crossref_primary_10_3389_fphar_2021_747895 crossref_primary_10_1016_S1470_2045_18_30119_0 crossref_primary_10_1186_s13256_019_1968_0 crossref_primary_10_3389_fonc_2021_740676 crossref_primary_10_2217_fon_2019_0534 crossref_primary_10_1038_nbt0817_694 crossref_primary_10_1093_annonc_mdz382 crossref_primary_10_5858_arpa_2018_0441_OA crossref_primary_10_1002_pbc_28011 crossref_primary_10_1111_ped_13229 crossref_primary_10_3390_cancers12010147 crossref_primary_10_1002_pbc_26593 crossref_primary_10_1007_s00432_022_04249_x crossref_primary_10_1016_j_cytogfr_2022_08_003 crossref_primary_10_1200_JCO_18_00573 crossref_primary_10_1002_pbc_26433 crossref_primary_10_1016_j_bulcan_2017_11_006 crossref_primary_10_1097_MD_0000000000034194
Cites_doi	10.1056/NEJMoa1403088 10.1158/1535-7163.TARG-15-PR13 10.1038/nrc3612 10.1002/gcc.20028 10.1038/ng.2938 10.1200/JCO.2009.21.9972 10.1002/cncr.29887 10.1016/j.ejca.2008.10.026 10.1038/ng0298-184 10.1007/0-306-48158-8_1 10.1016/j.semcancer.2005.01.003 10.1001/jamaoncol.2015.5689 10.1158/2159-8290.CD-15-0443 10.1126/science.1073096 10.1093/jnci/djv307 10.1038/modpathol.2016.37 10.1097/00043426-200212000-00008 10.1002/path.4701 10.1016/j.ejca.2015.12.028 10.1002/1097-0142(197608)38:2<729::AID-CNCR2820380216>3.0.CO;2-Z
ContentType	Journal Article
Copyright	2016 The Authors. , published by Wiley Periodicals, Inc. 2016 The Authors. Pediatric Blood & Cancer, published by Wiley Periodicals, Inc. 2016 Wiley Periodicals, Inc.
Copyright_xml	– notice: 2016 The Authors. , published by Wiley Periodicals, Inc. – notice: 2016 The Authors. Pediatric Blood & Cancer, published by Wiley Periodicals, Inc. – notice: 2016 Wiley Periodicals, Inc.
DBID	BSCLL 24P AAYXX CITATION CGR CUY CVF ECM EIF NPM 7T5 7TK 7TO 8FD FR3 H94 K9. P64 RC3 7X8 5PM
DOI	10.1002/pbc.26026
DatabaseName	Istex Wiley-Blackwell Open Access Titles CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Immunology Abstracts Neurosciences Abstracts Oncogenes and Growth Factors Abstracts Technology Research Database Engineering Research Database AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Biotechnology and BioEngineering Abstracts Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles)
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Genetics Abstracts Oncogenes and Growth Factors Abstracts Technology Research Database AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Immunology Abstracts Engineering Research Database Neurosciences Abstracts Biotechnology and BioEngineering Abstracts MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic MEDLINE Genetics Abstracts Oncogenes and Growth Factors Abstracts
Database_xml	– sequence: 1 dbid: 24P name: Wiley Online Library Open Access url: https://authorservices.wiley.com/open-science/open-access/browse-journals.html sourceTypes: Publisher – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine
DocumentTitleAlternate	Nagasubramanian et al
EISSN	1545-5017
EndPage	1470
ExternalDocumentID	PMC5074243 4095230881 27093299 10_1002_pbc_26026 PBC26026 ark_67375_WNG_F0M18RPN_5
Genre	article Research Support, Non-U.S. Gov't Journal Article Case Reports
GrantInformation_xml	– fundername: Loxo Oncology, Inc.
GroupedDBID	--- .3N .GA .Y3 05W 0R~ 10A 123 1L6 1OC 31~ 33P 3SF 3WU 4.4 4ZD 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5VS 66C 6PF 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 AAESR AAEVG AAHQN AAIPD AAMMB AAMNL AANHP AANLZ AAONW AASGY AAWTL AAXRX AAYCA AAZKR ABCQN ABCUV ABEML ABIJN ABPPZ ABPVW ABQWH ABXGK ACAHQ ACBWZ ACCZN ACFBH ACGFS ACGOF ACIWK ACMXC ACPOU ACPRK ACRPL ACSCC ACXBN ACXQS ACYXJ ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADNMO ADOZA ADXAS ADZMN AEFGJ AEIGN AEIMD AENEX AEUYR AEYWJ AFBPY AFFPM AFGKR AFRAH AFWVQ AFZJQ AGHNM AGQPQ AGXDD AGYGG AHBTC AHMBA AIACR AIDQK AIDYY AITYG AIURR ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN ALVPJ AMBMR AMYDB ATUGU AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMXJE BROTX BRXPI BSCLL BY8 C45 CS3 D-6 D-7 D-E D-F DCZOG DPXWK DR2 DRFUL DRMAN DRSTM DU5 EBD EBS EJD EMOBN F00 F01 F04 F5P FEDTE FUBAC G-S G.N GNP GODZA H.X HBH HF~ HGLYW HHY HHZ HVGLF HZ~ IX1 J0M JPC KBYEO KQQ LATKE LAW LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES MEWTI MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N9A NF~ NNB O66 O9- OIG OVD P2W P2X P2Z P4B P4D PQQKQ Q.N Q11 QB0 QRW R.K ROL RX1 RYL SUPJJ SV3 TEORI UB1 UDS V2E W8V W99 WBKPD WHWMO WIH WIJ WIK WJL WOHZO WQJ WVDHM WXI WXSBR XG1 XV2 ~IA ~WT 1OB 24P AAYXX CITATION O8X AAHHS ACCFJ AEEZP AEQDE AIWBW AJBDE CGR CUY CVF ECM EIF NPM 7T5 7TK 7TO 8FD FR3 H94 K9. P64 RC3 7X8 5PM
ID	FETCH-LOGICAL-c6546-973a461b24ab3d2bc2e170b7df632ccdaca43bcfc8061f4d534926df5de9bffb3
IEDL.DBID	24P
ISICitedReferencesCount	89
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000380108600025&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	1545-5009 1545-5017
IngestDate	Tue Nov 04 01:44:57 EST 2025 Thu Oct 02 06:44:55 EDT 2025 Wed Oct 01 09:40:36 EDT 2025 Sat Nov 29 14:29:32 EST 2025 Thu Apr 03 07:07:09 EDT 2025 Tue Nov 18 21:01:54 EST 2025 Sat Nov 29 06:01:44 EST 2025 Wed Aug 20 07:24:12 EDT 2025 Tue Nov 11 03:33:26 EST 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	8
Keywords	LOXO-101 ETV6-NTRK3 infantile fibrosarcoma tropomyosin-related kinase (TRK) gene fusion
Language	English
License	Attribution-NonCommercial-NoDerivs http://doi.wiley.com/10.1002/tdm_license_1.1 http://creativecommons.org/licenses/by-nc-nd/4.0 2016 The Authors. Pediatric Blood & Cancer, published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c6546-973a461b24ab3d2bc2e170b7df632ccdaca43bcfc8061f4d534926df5de9bffb3
Notes	Loxo Oncology, Inc. istex:FFB34EF41B208F6D04A3BFEB93672189A276053B ArticleID:PBC26026 ark:/67375/WNG-F0M18RPN-5 Grant sponsor: Loxo Oncology, Inc. Conflict of interest: Michael C. Cox, Pharm.D., MHSc, is an employee and stock holder of Loxo Oncology, Inc. All other authors have no conflict of interest to declare. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Case Study-2 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
OpenAccessLink	https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fpbc.26026
PMID	27093299
PQID	1798275489
PQPubID	1036357
PageCount	3
ParticipantIDs	pubmedcentral_primary_oai_pubmedcentral_nih_gov_5074243 proquest_miscellaneous_1808616273 proquest_miscellaneous_1799209370 proquest_journals_1798275489 pubmed_primary_27093299 crossref_citationtrail_10_1002_pbc_26026 crossref_primary_10_1002_pbc_26026 wiley_primary_10_1002_pbc_26026_PBC26026 istex_primary_ark_67375_WNG_F0M18RPN_5
PublicationCentury	2000
PublicationDate	August 2016
PublicationDateYYYYMMDD	2016-08-01
PublicationDate_xml	– month: 08 year: 2016 text: August 2016
PublicationDecade	2010
PublicationPlace	United States
PublicationPlace_xml	– name: United States – name: Glenview – name: Hoboken
PublicationTitle	Pediatric blood & cancer
PublicationTitleAlternate	Pediatr Blood Cancer
PublicationYear	2016
Publisher	Blackwell Publishing Ltd Wiley Subscription Services, Inc John Wiley and Sons Inc
Publisher_xml	– name: Blackwell Publishing Ltd – name: Wiley Subscription Services, Inc – name: John Wiley and Sons Inc
References	Knezevich SR, McFadden DE, Tao W, Lim JF, Sorensen PH. A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma. Nat Genet 1998;18:184-187. Orbach D, Brennan B, De Paoli A, Gallego S, Mudry P, Francotte N, van Noesel M, Kelsey A, Alaggio R, Ranchere D, De Salvo GL, Casanova M, Bergeron C, Merks JH, Jenney M, Stevens MC, Bisogno G, Ferrari A. Conservative strategy in infantile fibrosarcoma is possible: The European paediatric Soft tissue sarcoma Study Group experience. Eur J Cancer 2016;57:1-9. Doebele RC, Davis LE, Vaishnavi A, Le AT, Estrada-Bernal A, Keysar S, Jimeno A, Varella-Garcia M, Aisner DL, Li Y, Stephens PJ, Morosini D, Tuch BB, Fernandes M, Nanda N, Low JA. An oncogenic NTRK fusion in a patient with soft-tissue sarcoma with response to the tropomyosin-related kinase inhibitor LOXO-101. Cancer Discov 2015;5:1049-1057. Shaw AT, Hsu PP, Awad MM, Engelman JA. Tyrosine kinase gene rearrangements in epithelial malignancies. Nat Rev Cancer 2013;13:772-787. Wu G, Diaz AK, Paugh BS, Rankin SL, Ju B, Li Y, Zhu X, Qu C, Chen X, Zhang J, Easton J, Edmonson M, Ma X, Lu C, Nagahawatte P, Hedlund E, Rusch M, Pounds S, Lin T, Onar-Thomas A, et al. The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma. Nat Genet 2014;46:444-450. Harris MH, DuBois SG, Glade Bender JL, Kim A, Crompton BD, Parker E, Dumont IP, Hong AL, Guo D, Church A, Stegmaier K, Roberts CW, Shusterman S, London WB, MacConaill LE, Lindeman NI, Diller L, Rodriguez-Galindo C, Janeway KA. Multicenter feasibility study of tumor molecular profiling to inform therapeutic decisions in advanced pediatric solid tumors: The Individualized Cancer Therapy (iCat) Study. JAMA Oncol 2016. doi: 10.1001/jamaoncol.2015.5689. Chung EB, Enzinger FM. Infantile fibrosarcoma. Cancer 1976;38:729-739. Wu G, Barnhill RL, Lee S, Li Y, Shao Y, Easton J, Dalton J, Zhang J, Pappo A, Bahrami A. The landscape of fusion transcripts in spitzoid melanoma and biologically indeterminate spitzoid tumors by RNA sequencing. Mod Pathol 2016;29:359-369. Wong V, Pavlick D, Brennan T, Yelensky R, Crawford J, Ross JS, Miller VA, Malicki D, Stephens PJ, Ali SM, Ahn H. Evaluation of a congenital infantile fibrosarcoma by comprehensive genomic profiling reveals an LMNA-NTRK1 gene fusion responsive to Crizotinib. J Natl Cancer Inst 2016;108:djv307. doi: 10.1093/jnci/djv307 Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R, Dancey J, Arbuck S, Gwyther S, Mooney M, Rubinstein L, Shankar L, Dodd L, Kaplan R, Lacombe D, Verweij J. New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1). Eur J Cancer 2009;45:228-247. Knezevich SR, Garnett MJ, Pysher TJ, Beckwith JB, Grundy PE, Sorensen PH. ETV6-NTRK3 gene fusions and trisomy 11 establish a histogenetic link between mesoblastic nephroma and congenital fibrosarcoma. Cancer Res 1998;58:5046-5048. Prasad ML, Vyas M, Horne MJ, Virk RK, Morotti R, Liu Z, Tallini G, Nikiforova MN, Christison-Lagay ER, Udelsman R, Dinauer CA, Nikiforov YE. NTRK fusion oncogenes in pediatric papillary thyroid carcinoma in northeast United States. Cancer 2016;122:1097-1107. Haller F, Knopf J, Ackermann A, Bieg M, Kleinheinz K, Schlesner M, Moskalev EA, Will R, Satir AA, Abdelmagid IE, Giedl J, Carbon R, Rompel O, Hartmann A, Wiemann S, Metzler M, Agaimy A. Paediatric and adult soft tissue sarcomas with NTRK1 gene fusions: A subset of spindle cell sarcomas unified by a prominent myopericytic/haemangiopericytic pattern. J Pathol 2016;238:700-710. Hong DS, Brose MS, Doebele RC, Shaw AT, Dowlati A, Bauer TM, Farago AF, Estrada-Bernal A, Lee AT, Cox MC, Nanda N, Low JA, Burris HA. Abstract PR13: Clinical safety and activity from a phase 1 study of LOXO-101, a selective TRKA/B/C inhibitor, in solid-tumor patients with NTRK gene fusions. Mol Cancer Ther 2015;14(12 Suppl 2):PR13. Orbach D, Rey A, Cecchetto G, Oberlin O, Casanova M, Thebaud E, Scopinaro M, Bisogno G, Carli M, Ferrari A. Infantile fibrosarcoma: Management based on the European experience. J Clin Oncol 2010;28:318-323. Lannon CL, Sorensen PH. ETV6-NTRK3: A chimeric protein tyrosine kinase with transformation activity in multiple cell lineages. Semin Cancer Biol 2005;15:215-223. Roberts KG, Li Y, Payne-Turner D, Harvey RC, Yang YL, Pei D, McCastlain K, Ding L, Lu C, Song G, Ma J, Becksfort J, Rusch M, Chen SC, Easton J, Cheng J, Boggs K, Santiago-Morales N, Iacobucci I, Fulton RS, et al. Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia. N Engl J Med 2014;371:1005-1015. Makretsov N, He M, Hayes M, Chia S, Horsman DE, Sorensen PHB, Huntsman DG. A fluorescence in situ hybridization study of ETV6-NTRK3 fusion gene in secretory breast carcinoma. Genes Chromosomes Cancer 2004;40:152-157. Loh ML, Ahn P, Perez-Atayde AR, Gebhardt MC, Shamberger RC, Grier HE. Treatment of infantile fibrosarcoma with chemotherapy and surgery: Results from the Dana-Farber Cancer Institute and Children's Hospital, Boston. J Pediatr Hematol Oncol 2002;24:722-726. Rubin JB, Segal RA. Growth, survival and migration: The Trk to cancer. Cancer Treat Res 2003;115:1-18. Weinstein IB. Cancer. Addiction to oncogenes-The Achilles heal of cancer. Science 2002;297:63-64. 2009; 45 1998; 18 2015; 14 2015; 5 2004; 40 2002; 297 2013; 13 2016; 108 2010; 28 2002; 24 2016; 122 2014; 46 2016 2016; 238 2014; 371 2005; 15 2003; 115 2016; 29 1976; 38 2016; 57 1998; 58 e_1_2_7_6_1 e_1_2_7_5_1 e_1_2_7_4_1 e_1_2_7_3_1 e_1_2_7_9_1 e_1_2_7_8_1 e_1_2_7_7_1 Knezevich SR (e_1_2_7_12_1) 1998; 58 e_1_2_7_19_1 e_1_2_7_18_1 e_1_2_7_17_1 e_1_2_7_16_1 e_1_2_7_2_1 e_1_2_7_15_1 e_1_2_7_14_1 e_1_2_7_13_1 e_1_2_7_11_1 e_1_2_7_22_1 e_1_2_7_10_1 e_1_2_7_21_1 e_1_2_7_20_1
References_xml	– reference: Knezevich SR, Garnett MJ, Pysher TJ, Beckwith JB, Grundy PE, Sorensen PH. ETV6-NTRK3 gene fusions and trisomy 11 establish a histogenetic link between mesoblastic nephroma and congenital fibrosarcoma. Cancer Res 1998;58:5046-5048. – reference: Knezevich SR, McFadden DE, Tao W, Lim JF, Sorensen PH. A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma. Nat Genet 1998;18:184-187. – reference: Wu G, Barnhill RL, Lee S, Li Y, Shao Y, Easton J, Dalton J, Zhang J, Pappo A, Bahrami A. The landscape of fusion transcripts in spitzoid melanoma and biologically indeterminate spitzoid tumors by RNA sequencing. Mod Pathol 2016;29:359-369. – reference: Haller F, Knopf J, Ackermann A, Bieg M, Kleinheinz K, Schlesner M, Moskalev EA, Will R, Satir AA, Abdelmagid IE, Giedl J, Carbon R, Rompel O, Hartmann A, Wiemann S, Metzler M, Agaimy A. Paediatric and adult soft tissue sarcomas with NTRK1 gene fusions: A subset of spindle cell sarcomas unified by a prominent myopericytic/haemangiopericytic pattern. J Pathol 2016;238:700-710. – reference: Lannon CL, Sorensen PH. ETV6-NTRK3: A chimeric protein tyrosine kinase with transformation activity in multiple cell lineages. Semin Cancer Biol 2005;15:215-223. – reference: Wong V, Pavlick D, Brennan T, Yelensky R, Crawford J, Ross JS, Miller VA, Malicki D, Stephens PJ, Ali SM, Ahn H. Evaluation of a congenital infantile fibrosarcoma by comprehensive genomic profiling reveals an LMNA-NTRK1 gene fusion responsive to Crizotinib. J Natl Cancer Inst 2016;108:djv307. doi: 10.1093/jnci/djv307 – reference: Weinstein IB. Cancer. Addiction to oncogenes-The Achilles heal of cancer. Science 2002;297:63-64. – reference: Rubin JB, Segal RA. Growth, survival and migration: The Trk to cancer. Cancer Treat Res 2003;115:1-18. – reference: Loh ML, Ahn P, Perez-Atayde AR, Gebhardt MC, Shamberger RC, Grier HE. Treatment of infantile fibrosarcoma with chemotherapy and surgery: Results from the Dana-Farber Cancer Institute and Children's Hospital, Boston. J Pediatr Hematol Oncol 2002;24:722-726. – reference: Orbach D, Rey A, Cecchetto G, Oberlin O, Casanova M, Thebaud E, Scopinaro M, Bisogno G, Carli M, Ferrari A. Infantile fibrosarcoma: Management based on the European experience. J Clin Oncol 2010;28:318-323. – reference: Harris MH, DuBois SG, Glade Bender JL, Kim A, Crompton BD, Parker E, Dumont IP, Hong AL, Guo D, Church A, Stegmaier K, Roberts CW, Shusterman S, London WB, MacConaill LE, Lindeman NI, Diller L, Rodriguez-Galindo C, Janeway KA. Multicenter feasibility study of tumor molecular profiling to inform therapeutic decisions in advanced pediatric solid tumors: The Individualized Cancer Therapy (iCat) Study. JAMA Oncol 2016. doi: 10.1001/jamaoncol.2015.5689. – reference: Doebele RC, Davis LE, Vaishnavi A, Le AT, Estrada-Bernal A, Keysar S, Jimeno A, Varella-Garcia M, Aisner DL, Li Y, Stephens PJ, Morosini D, Tuch BB, Fernandes M, Nanda N, Low JA. An oncogenic NTRK fusion in a patient with soft-tissue sarcoma with response to the tropomyosin-related kinase inhibitor LOXO-101. Cancer Discov 2015;5:1049-1057. – reference: Chung EB, Enzinger FM. Infantile fibrosarcoma. Cancer 1976;38:729-739. – reference: Roberts KG, Li Y, Payne-Turner D, Harvey RC, Yang YL, Pei D, McCastlain K, Ding L, Lu C, Song G, Ma J, Becksfort J, Rusch M, Chen SC, Easton J, Cheng J, Boggs K, Santiago-Morales N, Iacobucci I, Fulton RS, et al. Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia. N Engl J Med 2014;371:1005-1015. – reference: Wu G, Diaz AK, Paugh BS, Rankin SL, Ju B, Li Y, Zhu X, Qu C, Chen X, Zhang J, Easton J, Edmonson M, Ma X, Lu C, Nagahawatte P, Hedlund E, Rusch M, Pounds S, Lin T, Onar-Thomas A, et al. The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma. Nat Genet 2014;46:444-450. – reference: Prasad ML, Vyas M, Horne MJ, Virk RK, Morotti R, Liu Z, Tallini G, Nikiforova MN, Christison-Lagay ER, Udelsman R, Dinauer CA, Nikiforov YE. NTRK fusion oncogenes in pediatric papillary thyroid carcinoma in northeast United States. Cancer 2016;122:1097-1107. – reference: Orbach D, Brennan B, De Paoli A, Gallego S, Mudry P, Francotte N, van Noesel M, Kelsey A, Alaggio R, Ranchere D, De Salvo GL, Casanova M, Bergeron C, Merks JH, Jenney M, Stevens MC, Bisogno G, Ferrari A. Conservative strategy in infantile fibrosarcoma is possible: The European paediatric Soft tissue sarcoma Study Group experience. Eur J Cancer 2016;57:1-9. – reference: Makretsov N, He M, Hayes M, Chia S, Horsman DE, Sorensen PHB, Huntsman DG. A fluorescence in situ hybridization study of ETV6-NTRK3 fusion gene in secretory breast carcinoma. Genes Chromosomes Cancer 2004;40:152-157. – reference: Shaw AT, Hsu PP, Awad MM, Engelman JA. Tyrosine kinase gene rearrangements in epithelial malignancies. Nat Rev Cancer 2013;13:772-787. – reference: Hong DS, Brose MS, Doebele RC, Shaw AT, Dowlati A, Bauer TM, Farago AF, Estrada-Bernal A, Lee AT, Cox MC, Nanda N, Low JA, Burris HA. Abstract PR13: Clinical safety and activity from a phase 1 study of LOXO-101, a selective TRKA/B/C inhibitor, in solid-tumor patients with NTRK gene fusions. Mol Cancer Ther 2015;14(12 Suppl 2):PR13. – reference: Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R, Dancey J, Arbuck S, Gwyther S, Mooney M, Rubinstein L, Shankar L, Dodd L, Kaplan R, Lacombe D, Verweij J. New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1). Eur J Cancer 2009;45:228-247. – volume: 115 start-page: 1 year: 2003 end-page: 18 article-title: Growth, survival and migration: The Trk to cancer publication-title: Cancer Treat Res – year: 2016 article-title: Multicenter feasibility study of tumor molecular profiling to inform therapeutic decisions in advanced pediatric solid tumors: The Individualized Cancer Therapy (iCat) Study publication-title: JAMA Oncol – volume: 14 start-page: PR13 issue: 12 Suppl 2 year: 2015 article-title: Abstract PR13: Clinical safety and activity from a phase 1 study of LOXO‐101, a selective TRKA/B/C inhibitor, in solid‐tumor patients with NTRK gene fusions publication-title: Mol Cancer Ther – volume: 46 start-page: 444 year: 2014 end-page: 450 article-title: The genomic landscape of diffuse intrinsic pontine glioma and pediatric non‐brainstem high‐grade glioma publication-title: Nat Genet – volume: 29 start-page: 359 year: 2016 end-page: 369 article-title: The landscape of fusion transcripts in spitzoid melanoma and biologically indeterminate spitzoid tumors by RNA sequencing publication-title: Mod Pathol – volume: 24 start-page: 722 year: 2002 end-page: 726 article-title: Treatment of infantile fibrosarcoma with chemotherapy and surgery: Results from the Dana‐Farber Cancer Institute and Children's Hospital, Boston publication-title: J Pediatr Hematol Oncol – volume: 57 start-page: 1 year: 2016 end-page: 9 article-title: Conservative strategy in infantile fibrosarcoma is possible: The European paediatric Soft tissue sarcoma Study Group experience publication-title: Eur J Cancer – volume: 238 start-page: 700 year: 2016 end-page: 710 article-title: Paediatric and adult soft tissue sarcomas with NTRK1 gene fusions: A subset of spindle cell sarcomas unified by a prominent myopericytic/haemangiopericytic pattern publication-title: J Pathol – volume: 108 year: 2016 article-title: Evaluation of a congenital infantile fibrosarcoma by comprehensive genomic profiling reveals an LMNA‐NTRK1 gene fusion responsive to Crizotinib publication-title: J Natl Cancer Inst – volume: 40 start-page: 152 year: 2004 end-page: 157 article-title: A fluorescence in situ hybridization study of ETV6‐NTRK3 fusion gene in secretory breast carcinoma publication-title: Genes Chromosomes Cancer – volume: 15 start-page: 215 year: 2005 end-page: 223 article-title: ETV6‐NTRK3: A chimeric protein tyrosine kinase with transformation activity in multiple cell lineages publication-title: Semin Cancer Biol – volume: 45 start-page: 228 year: 2009 end-page: 247 article-title: New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1) publication-title: Eur J Cancer – volume: 58 start-page: 5046 year: 1998 end-page: 5048 article-title: ETV6‐NTRK3 gene fusions and trisomy 11 establish a histogenetic link between mesoblastic nephroma and congenital fibrosarcoma publication-title: Cancer Res – volume: 28 start-page: 318 year: 2010 end-page: 323 article-title: Infantile fibrosarcoma: Management based on the European experience publication-title: J Clin Oncol – volume: 13 start-page: 772 year: 2013 end-page: 787 article-title: Tyrosine kinase gene rearrangements in epithelial malignancies publication-title: Nat Rev Cancer – volume: 122 start-page: 1097 year: 2016 end-page: 1107 article-title: NTRK fusion oncogenes in pediatric papillary thyroid carcinoma in northeast United States publication-title: Cancer – volume: 371 start-page: 1005 year: 2014 end-page: 1015 article-title: Targetable kinase‐activating lesions in Ph‐like acute lymphoblastic leukemia publication-title: N Engl J Med – volume: 5 start-page: 1049 year: 2015 end-page: 1057 article-title: An oncogenic NTRK fusion in a patient with soft‐tissue sarcoma with response to the tropomyosin‐related kinase inhibitor LOXO‐101 publication-title: Cancer Discov – volume: 297 start-page: 63 year: 2002 end-page: 64 article-title: Cancer. Addiction to oncogenes—The Achilles heal of cancer publication-title: Science – volume: 38 start-page: 729 year: 1976 end-page: 739 article-title: Infantile fibrosarcoma publication-title: Cancer – volume: 18 start-page: 184 year: 1998 end-page: 187 article-title: A novel ETV6‐NTRK3 gene fusion in congenital fibrosarcoma publication-title: Nat Genet – ident: e_1_2_7_18_1 doi: 10.1056/NEJMoa1403088 – ident: e_1_2_7_22_1 doi: 10.1158/1535-7163.TARG-15-PR13 – ident: e_1_2_7_10_1 doi: 10.1038/nrc3612 – ident: e_1_2_7_13_1 doi: 10.1002/gcc.20028 – ident: e_1_2_7_15_1 doi: 10.1038/ng.2938 – ident: e_1_2_7_5_1 doi: 10.1200/JCO.2009.21.9972 – ident: e_1_2_7_16_1 doi: 10.1002/cncr.29887 – ident: e_1_2_7_8_1 doi: 10.1016/j.ejca.2008.10.026 – ident: e_1_2_7_11_1 doi: 10.1038/ng0298-184 – ident: e_1_2_7_14_1 doi: 10.1007/0-306-48158-8_1 – ident: e_1_2_7_6_1 doi: 10.1016/j.semcancer.2005.01.003 – ident: e_1_2_7_19_1 doi: 10.1001/jamaoncol.2015.5689 – ident: e_1_2_7_7_1 doi: 10.1158/2159-8290.CD-15-0443 – ident: e_1_2_7_9_1 doi: 10.1126/science.1073096 – ident: e_1_2_7_21_1 doi: 10.1093/jnci/djv307 – ident: e_1_2_7_17_1 doi: 10.1038/modpathol.2016.37 – ident: e_1_2_7_3_1 doi: 10.1097/00043426-200212000-00008 – ident: e_1_2_7_20_1 doi: 10.1002/path.4701 – ident: e_1_2_7_4_1 doi: 10.1016/j.ejca.2015.12.028 – volume: 58 start-page: 5046 year: 1998 ident: e_1_2_7_12_1 article-title: ETV6‐NTRK3 gene fusions and trisomy 11 establish a histogenetic link between mesoblastic nephroma and congenital fibrosarcoma publication-title: Cancer Res – ident: e_1_2_7_2_1 doi: 10.1002/1097-0142(197608)38:2<729::AID-CNCR2820380216>3.0.CO;2-Z
SSID	ssj0026058
Score	2.4812584
Snippet	Infantile fibrosarcoma (IFS) is a rare pediatric cancer typically presenting in the first 2 years of life. Surgical resection is usually curative and...
SourceID	pubmedcentral proquest pubmed crossref wiley istex
SourceType	Open Access Repository Aggregation Database Index Database Enrichment Source Publisher
StartPage	1468
SubjectTerms	Brief Report Brief Reports ETS Translocation Variant 6 Protein ETV6-NTRK3 Female Fibrosarcoma - diagnostic imaging Fibrosarcoma - drug therapy Fibrosarcoma - genetics Fibrosarcoma - surgery gene fusion Genes Hematology Humans Infant infantile fibrosarcoma Kinases LOXO-101 Magnetic Resonance Imaging Oncology Pediatrics Proto-Oncogene Proteins c-ets - genetics Pyrazoles - therapeutic use Pyrimidines - therapeutic use Receptor, trkC - antagonists & inhibitors Receptor, trkC - genetics Recombinant Fusion Proteins - genetics Repressor Proteins - genetics tropomyosin-related kinase (TRK)
Title	Infantile Fibrosarcoma With NTRK3-ETV6 Fusion Successfully Treated With the Tropomyosin-Related Kinase Inhibitor LOXO-101
URI	https://api.istex.fr/ark:/67375/WNG-F0M18RPN-5/fulltext.pdf https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fpbc.26026 https://www.ncbi.nlm.nih.gov/pubmed/27093299 https://www.proquest.com/docview/1798275489 https://www.proquest.com/docview/1799209370 https://www.proquest.com/docview/1808616273 https://pubmed.ncbi.nlm.nih.gov/PMC5074243
Volume	63
WOSCitedRecordID	wos000380108600025&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVWIB databaseName: Wiley Online Library Full Collection 2020 customDbUrl: eissn: 1545-5017 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0026058 issn: 1545-5009 databaseCode: DRFUL dateStart: 20040101 isFulltext: true titleUrlDefault: https://onlinelibrary.wiley.com providerName: Wiley-Blackwell
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1bb9MwFD4aK0K8cL8ExhQQQnsJS2znJp5gLDCt66rSbX2LfEnUCJZUTYvYE_sJSPzD_RKOnTZQMRASL1EUH1vO8Tn259t3AJ6rWMjYz3z0NCoc5pHc4YpFDo9pzrHBY9-Q6Rx3w14vGo3i_hq8Wt6Fafgh2gU37Rmmv9YOzkW9_ZM0dCLkS6IDKF2BjufRSMdtIKzfzrb0fp8hS2W-4yOSWNIKuWS7zboyGHW0Xr9chjR_PzD5K5A1I1Fy87_-4RbcWABQ-3VjMbdhLSvvwLWDxRb7Xfi6V-aobSzOTrDsqkZPqE65fVLMxnZvONinF-ffd4fHgZ3M9Uqb_WFuYi7qdfwze6gxaKYaacSW-KGaVKdnVV2UF-ffzNE7TN4vShw97b1yXAjsUqZ293B0iOnouffgKNkd7rx3FlEaHKkvQjlxSDkLPEEYF1QRIUnmha4IVR5QIqXikjMqZC4jhA45U77mQwxU7qssFnku6H1YL6syewh2xpRQGRGMSZxIxZrKPgiIRwMuiEuVsGBr2VypXFCY60gan9KGfJmkqNDUKNSCZ63opOHtuEzohWnzVoJPP-qDbqGfnvTepYl74EWDfi_1LdhYGkW68PE61VRvJNQVteBpm4zeqbdceJlVcyMTExchoPsXmQinlV6AONKCB42dtRUiIWZGxGBBuGKBrYBmB19NKYuxYQn39aoHwzK3jAX-WQtp_82OeXn076KP4Toix6A5CbkB67PpPHsCV-XnWVFPN40j4jMcRZvQeTtIjro_APs1O0U
linkProvider	Wiley-Blackwell
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1bb9MwFD4aG2K8cGcEBgSE0F7CUse5SbzAtLKqbVaNsvXN8iVRI1hS9YLYE_sJSPzD_RKOnTRQMRASb1F87DjH59ifj-3PAC9ULGTspz56micc2iKZwxWNHB57GccGj31DpnPcC5MkGo3iwRq8Xp6FqfghmoCb9gzTX2sH1wHp3Z-soRMhXxF9g9IV2KA4ymgrJ3TQTLf0gp9hS6W-4yOUWPIKuWS3yboyGm1oxX65DGr-vmPyVyRrhqL2zf_7iVtwo4ag9pvKZm7DWlrcgWv9epH9LnztFBnqG8uz21h4OUNfKE-5fZLPx3YyPOp6F-ff94fHgd1e6Fib_X5hbl3U3zyzhxqFpqqSRnSJL8pJeXpWzvLi4vyb2XyHyd28wPHT7hTjXGCnMrV7h6NDTEffvQcf2vvDvQOnvqfBkfoolBOHHscGEIRy4SkiJElboStClQUekVJxyaknZCYjBA8ZVb5mRAxU5qs0FlkmvPuwXpRF-gDslCqhUiIolTiVijWZfRCQlhdwQVxPCQt2lu3FZE1iru_S-MQq-mXCUKHMKNSC543opGLuuEzopWn0RoJPP-qtbqHPTpJ3rO32W9HRIGG-BdtLq2C1l8-YJnsjoa6oBc-aZPRPvejCi7RcGJmYuAgC3b_IRDixbAWIJC3YqgytqRAJMTNiBgvCFRNsBDQ_-GpKkY8NT7iv4x4Uy9wxJvhnLbDB2z3z8PDfRZ_C5sGw32O9TtJ9BNcRRwbVvshtWJ9PF-ljuCo_z_PZ9Inxyh9byjyo
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1bb9MwFLZGiyZeuF8CAwJCaC9hieMkjcQLbAtU7bKqdFvfLN-iRrCk6gWxJ_YTkPiH-yUcO2mgYiAk3qL42EqOz7E_H9vfQeiFjLmIAxWAp_ncIR7OHCZJx2GxnzHo8DgwZDrH_ShNO-NxPNhAr1d3YSp-iCbgpj3DjNfawdVUZjs_WUOnXLzCOoPSFdQmOolMC7X3hslRv1lw6S0_w5dKAicAMLFiFnLxTlN5bT5qa9V-uQxs_n5m8lcsayaj5Mb__cZNdL0GofabympuoQ1V3EabB_U2-x30tVtkoHFoz06g8XIO3lCeMvskX0zsdDTs-Rfn3_dHx6GdLHW0zf6wNHkXdSz_zB5pHKpkJQ34El6U0_L0rJznxcX5N3P8Dop7eQEzqN0tJjmHYWVm9w_Hh1AO3nsXHSX7o933Tp2pwRH6MpQTRz4joccxYdyXmAusvMjlkcxCHwshmWDE5yITHYAPGZGB5kQMZRZIFfMs4_491CrKQj1AtiKSS4U5IQIWU7Gmsw9D7Pkh49j1JbfQ9qq_qKhpzHU2jU-0ImDGFBRKjUIt9LwRnVbcHZcJvTSd3kiw2Ud92C0K6En6jibugdcZDlIaWGhrZRW09vM51XRvONIfaqFnTTF4qN52YYUql0Ymxi7AQPcvMh1YWnohYEkL3a8MrfkgHEFlQA0WitZMsBHQDOHrJUU-MUzhgY58EGhz25jgn7VAB293zcPDfxd9ijYHewntd9PeI3QNgGRYHYzcQq3FbKkeo6vi8yKfz57UbvkDQzc9vg
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Infantile+Fibrosarcoma+With+NTRK3%E2%80%93ETV6+Fusion+Successfully+Treated+With+the+Tropomyosin%E2%80%90Related+Kinase+Inhibitor+LOXO%E2%80%90101&rft.jtitle=Pediatric+blood+%26+cancer&rft.au=Nagasubramanian%2C+Ramamoorthy&rft.au=Wei%2C+Julie&rft.au=Gordon%2C+Paul&rft.au=Rastatter%2C+Jeff+C.&rft.date=2016-08-01&rft.issn=1545-5009&rft.eissn=1545-5017&rft.volume=63&rft.issue=8&rft.spage=1468&rft.epage=1470&rft_id=info:doi/10.1002%2Fpbc.26026&rft.externalDBID=10.1002%252Fpbc.26026&rft.externalDocID=PBC26026
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1545-5009&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1545-5009&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1545-5009&client=summon