A new highly penetrant form of obesity due to deletions on chromosome 16p11.2

Genetic link to obesity Obesity is a highly heritable disorder but the genetic associations reported to date account for only a small percentage of the inherited variation in body mass index. Two groups report deletions on chromosome16p11.2 that may explain part of the 'missing heritability...

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Vydáno v:	Nature (London) Ročník 463; číslo 7281; s. 671 - 675
Hlavní autoři:	Walters, R. G., Jacquemont, S., Valsesia, A., de Smith, A. J., Martinet, D., Andersson, J., Falchi, M., Chen, F., Andrieux, J., Lobbens, S., Delobel, B., Stutzmann, F., El-Sayed Moustafa, J. S., Chèvre, J.-C., Lecoeur, C., Vatin, V., Bouquillon, S., Buxton, J. L., Boute, O., Holder-Espinasse, M., Cuisset, J.-M., Lemaitre, M.-P., Ambresin, A.-E., Brioschi, A., Gaillard, M., Giusti, V., Fellmann, F., Ferrarini, A., Hadjikhani, N., Campion, D., Guilmatre, A., Goldenberg, A., Calmels, N., Mandel, J.-L., Le Caignec, C., David, A., Isidor, B., Cordier, M.-P., Dupuis-Girod, S., Labalme, A., Sanlaville, D., Béri-Dexheimer, M., Jonveaux, P., Leheup, B., Õunap, K., Bochukova, E. G., Henning, E., Keogh, J., Ellis, R. J., MacDermot, K. D., van Haelst, M. M., Vincent-Delorme, C., Plessis, G., Touraine, R., Philippe, A., Malan, V., Mathieu-Dramard, M., Chiesa, J., Blaumeiser, B., Kooy, R. F., Caiazzo, R., Pigeyre, M., Balkau, B., Sladek, R., Bergmann, S., Mooser, V., Waterworth, D., Reymond, A., Vollenweider, P., Waeber, G., Kurg, A., Palta, P., Esko, T., Metspalu, A., Nelis, M., Elliott, P., Hartikainen, A.-L., McCarthy, M. I., Peltonen, L., Carlsson, L., Jacobson, P., Sjöström, L., Huang, N., Hurles, M. E., O’Rahilly, S., Farooqi, I. S., Männik, K., Jarvelin, M.-R., Pattou, F., Meyre, D., Walley, A. J., Coin, L. J. M., Blakemore, A. I. F., Froguel, P., Beckmann, J. S.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 04.02.2010 Nature Publishing Group
Témata:	631/208/2489/144 631/208/737 692/699/2743/393 Adolescent Adult Age of Onset Aging Autism Biological and medical sciences Body Mass Index Case-Control Studies Child Chromosome Deletion Chromosomes Chromosomes, Human, Pair 16 - genetics Cognition Disorders Cognition Disorders - complications Cognition Disorders - genetics Cohort Studies complications Deletion Europe Female Genetics Genome-Wide Association Study Genotype & phenotype Heterozygote Human Humanities and Social Sciences Humans Inheritance Patterns Inheritance Patterns - genetics letter Life Sciences Loci Male Medical Genetics and Genomics Medical sciences Medicinsk genetik och genomik Metabolic diseases multidisciplinary Mutation Mutation - genetics Nuclear power generation Nucleotides Obesity Obesity - complications Obesity - genetics Obesity - physiopathology Pair 16 Penetrance Penetrants physiopathology Public health Reproducibility of Results Science Science (multidisciplinary) Sex Characteristics Studies Young Adult Europe Deletion Obesity Chromosome Nutritional status Nutrition disorder
ISSN:	0028-0836, 1476-4687, 1476-4687
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