Molecular typing of PPRV strains detected during an outbreak in sheep and goats in south-eastern Gabon in 2011

BACKGROUND: Peste des petits ruminanats (PPR) is an economically important viral disease affecting goats and sheep. Four genetically distinct lineages of peste des petits ruminants virus (PPRV) have been identified. In Gabon, the virus has not so far been detected. FINDINGS: Epidemiological investig...

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Veröffentlicht in:Virology journal Jg. 10; H. 1; S. 82
Hauptverfasser: Maganga, Gael D, Verrier, Delphine, Zerbinati, Rodrigo M, Drosten, Christian, Drexler, Jan F, Leroy, Eric M
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London Springer-Verlag 11.03.2013
BioMed Central
BioMed Central Ltd
Springer Nature B.V
Schlagworte:
Animal diseases
Animals
Biomedical and Life Sciences
Biomedicine
Cameroon
Cluster Analysis
Disease Outbreaks
epidemiological studies
Fatalities
Gabon
Gabon - epidemiology
Genes
Genetic aspects
Genotype
Goat Diseases - epidemiology
Goat Diseases - virology
Goats
Health aspects
Microbiology
Molecular Epidemiology
Molecular Sequence Data
Molecular Typing
mortality
Paramyxoviruses
Peste-des-Petits-Ruminants - epidemiology
Peste-des-Petits-Ruminants - virology
Peste-des-petits-ruminants virus
Peste-des-petits-ruminants virus - classification
Peste-des-petits-ruminants virus - genetics
Peste-des-petits-ruminants virus - isolation & purification
Phylogenetics
Phylogeny
Physiological aspects
RNA
RNA, Viral - genetics
Ruminantia
Rural areas
Rural development
Sequence Analysis, DNA
Sheep
Sheep Diseases - epidemiology
Sheep Diseases - virology
Short Report
villages
Virology
Virus diseases
viruses
Gabon
Cameroon
Central African Republic
France
Germany
Uganda
Central Africa
Asia
Africa
Gabon
Sheep
Molecular typing
Peste des petits ruminants virus
ISSN:1743-422X, 1743-422X
Online-Zugang:Volltext
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Zusammenfassung:BACKGROUND: Peste des petits ruminanats (PPR) is an economically important viral disease affecting goats and sheep. Four genetically distinct lineages of peste des petits ruminants virus (PPRV) have been identified. In Gabon, the virus has not so far been detected. FINDINGS: Epidemiological investigations of Aboumi PPR outbreak revealed a high case fatality rate in sheep (98.9%). We detected and characterized peste des petits ruminants virus (PPRV), in October 2011, during the suspected outbreak in sheep and goats in Aboumi village located in the south-eastern. PPRV RNA was detected in 10 of 14 samples from three sick animals. Phylogenetic analysis revealed that the PPRV strain belonged to lineage IV and was closely related to strain circulating in neighboring Cameroon. CONCLUSIONS: This is the first molecular detection and typing of the PPRV strain associated with fatal PPR infection in these small ruminants and concrete evidence that PPRV is present and circulating in Gabon.
Bibliographie:http://dx.doi.org/10.1186/1743-422X-10-82
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ISSN:1743-422X
1743-422X
DOI:10.1186/1743-422X-10-82