Molecular typing of PPRV strains detected during an outbreak in sheep and goats in south-eastern Gabon in 2011

BACKGROUND: Peste des petits ruminanats (PPR) is an economically important viral disease affecting goats and sheep. Four genetically distinct lineages of peste des petits ruminants virus (PPRV) have been identified. In Gabon, the virus has not so far been detected. FINDINGS: Epidemiological investig...

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Vydáno v:	Virology journal Ročník 10; číslo 1; s. 82
Hlavní autoři:	Maganga, Gael D, Verrier, Delphine, Zerbinati, Rodrigo M, Drosten, Christian, Drexler, Jan F, Leroy, Eric M
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Springer-Verlag 11.03.2013 BioMed Central BioMed Central Ltd Springer Nature B.V
Témata:	Animal diseases Animals Biomedical and Life Sciences Biomedicine Cameroon Cluster Analysis Disease Outbreaks epidemiological studies Fatalities Gabon Gabon - epidemiology Genes Genetic aspects Genotype Goat Diseases - epidemiology Goat Diseases - virology Goats Health aspects Microbiology Molecular Epidemiology Molecular Sequence Data Molecular Typing mortality Paramyxoviruses Peste-des-Petits-Ruminants - epidemiology Peste-des-Petits-Ruminants - virology Peste-des-petits-ruminants virus Peste-des-petits-ruminants virus - classification Peste-des-petits-ruminants virus - genetics Peste-des-petits-ruminants virus - isolation & purification Phylogenetics Phylogeny Physiological aspects RNA RNA, Viral - genetics Ruminantia Rural areas Rural development Sequence Analysis, DNA Sheep Sheep Diseases - epidemiology Sheep Diseases - virology Short Report villages Virology Virus diseases viruses Gabon Cameroon Central African Republic France Germany Uganda Central Africa Asia Africa Gabon Sheep Molecular typing Peste des petits ruminants virus
ISSN:	1743-422X, 1743-422X
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Popis
Shrnutí:	BACKGROUND: Peste des petits ruminanats (PPR) is an economically important viral disease affecting goats and sheep. Four genetically distinct lineages of peste des petits ruminants virus (PPRV) have been identified. In Gabon, the virus has not so far been detected. FINDINGS: Epidemiological investigations of Aboumi PPR outbreak revealed a high case fatality rate in sheep (98.9%). We detected and characterized peste des petits ruminants virus (PPRV), in October 2011, during the suspected outbreak in sheep and goats in Aboumi village located in the south-eastern. PPRV RNA was detected in 10 of 14 samples from three sick animals. Phylogenetic analysis revealed that the PPRV strain belonged to lineage IV and was closely related to strain circulating in neighboring Cameroon. CONCLUSIONS: This is the first molecular detection and typing of the PPRV strain associated with fatal PPR infection in these small ruminants and concrete evidence that PPRV is present and circulating in Gabon.
Bibliografie:	http://dx.doi.org/10.1186/1743-422X-10-82 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Article-2 ObjectType-Feature-1
ISSN:	1743-422X 1743-422X
DOI:	10.1186/1743-422X-10-82