RBM22 regulates RNA polymerase II 5′ pausing, elongation rate, and termination by coordinating 7SK-P-TEFb complex and SPT5

Background Splicing factors are vital for the regulation of RNA splicing, but some have also been implicated in regulating transcription. The underlying molecular mechanisms of their involvement in transcriptional processes remain poorly understood. Results Here, we describe a direct role of splicin...

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Vydáno v:	Genome Biology Ročník 25; číslo 1; s. 102
Hlavní autoři:	Du, Xian, Qin, Wenying, Yang, Chunyu, Dai, Lin, San, Mingkui, Xia, Yingdan, Zhou, Siyu, Wang, Mengyang, Wu, Shuang, Zhang, Shaorui, Zhou, Huiting, Li, Fangshu, He, Fang, Tang, Jingfeng, Chen, Jia-Yu, Zhou, Yu, Xiao, Rui
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London BioMed Central 19.04.2024 Springer Nature B.V BMC
Témata:	5′ pausing Animal Genetics and Genomics Bioinformatics Biomedical and Life Sciences Chromatin DNA-directed RNA polymerase Elongation Evolutionary Biology Gene expression genes Genomes Homeostasis Human Genetics Humans Life Sciences loci Microbial Genetics and Genomics Molecular modelling Plant Genetics and Genomics Positive Transcriptional Elongation Factor B - genetics Positive Transcriptional Elongation Factor B - metabolism Proteins RBM22 RNA RNA polymerase RNA polymerase II RNA Polymerase II - metabolism RNA Splicing RNA Splicing Factors - genetics Splicing factors transcription (genetics) Transcription elongation Transcription termination Transcription, Genetic Transcriptional Elongation Factors - genetics Transcriptional Elongation Factors - metabolism Transcription termination Transcription elongation RNA polymerase II 5′ pausing RBM22
ISSN:	1474-760X, 1474-7596, 1474-760X
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