Spatio-temporal analysis of prostate tumors in situ suggests pre-existence of treatment-resistant clones

The molecular mechanisms underlying lethal castration-resistant prostate cancer remain poorly understood, with intratumoral heterogeneity a likely contributing factor. To examine the temporal aspects of resistance, we analyze tumor heterogeneity in needle biopsies collected before and after treatmen...

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Bibliographic Details
Published in:	Nature communications Vol. 13; no. 1; pp. 5475 - 18
Main Authors:	Marklund, Maja, Schultz, Niklas, Friedrich, Stefanie, Berglund, Emelie, Tarish, Firas, Tanoglidi, Anna, Liu, Yao, Bergenstråhle, Ludvig, Erickson, Andrew, Helleday, Thomas, Lamb, Alastair D., Sonnhammer, Erik, Lundeberg, Joakim
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 17.09.2022 Nature Publishing Group Nature Portfolio
Subjects:	13 38 45/77 631/61/212/2019 631/67/2329 631/67/589/466 631/67/69 692/53/2422 82/1 Androgen Antagonists - pharmacology Androgen Antagonists - therapeutic use Androgen receptors Androgens Androgens - metabolism Biopsy Castration Clone Cells - metabolism Clusters Data analysis Deprivation Gene expression Heterogeneity Humanities and Social Sciences Humans Localization Male Molecular modelling multidisciplinary Populations Prostate cancer Prostatic Neoplasms - drug therapy Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Quorum sensing Receptors Receptors, Androgen - genetics Receptors, Androgen - metabolism Science Science (multidisciplinary) Spatial heterogeneity Spatio-Temporal Analysis Stromal cells Transcriptomes Transcriptomics Tumors
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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