Efficacy and effectiveness of an rVSV-vectored vaccine expressing Ebola surface glycoprotein: interim results from the Guinea ring vaccination cluster-randomised trial

A recombinant, replication-competent vesicular stomatitis virus-based vaccine expressing a surface glycoprotein of Zaire Ebolavirus (rVSV-ZEBOV) is a promising Ebola vaccine candidate. We report the results of an interim analysis of a trial of rVSV-ZEBOV in Guinea, west Africa. For this open-label,...

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Veröffentlicht in:	The Lancet (British edition) Jg. 386; H. 9996; S. 857 - 866
Hauptverfasser:	Henao-Restrepo, Ana Maria, Longini, Ira M, Egger, Matthias, Dean, Natalie E, Edmunds, W John, Camacho, Anton, Carroll, Miles W, Doumbia, Moussa, Draguez, Bertrand, Duraffour, Sophie, Enwere, Godwin, Grais, Rebecca, Gunther, Stephan, Hossmann, Stefanie, Kondé, Mandy Kader, Kone, Souleymane, Kuisma, Eeva, Levine, Myron M, Mandal, Sema, Norheim, Gunnstein, Riveros, Ximena, Soumah, Aboubacar, Trelle, Sven, Vicari, Andrea S, Watson, Conall H, Kéïta, Sakoba, Kieny, Marie Paule, Røttingen, John-Arne
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Elsevier Ltd 29.08.2015 Elsevier Limited
Schlagworte:	Adult Breast feeding Clinical trials Ebola Vaccines Ebola virus Ebolavirus - immunology Female Genetic Vectors Glycoproteins Guinea - epidemiology Hemorrhagic Fever, Ebola - epidemiology Hemorrhagic Fever, Ebola - prevention & control Humans Immunization Incidence Internal Medicine Kaplan-Meier Estimate Male Membrane Glycoproteins - metabolism Middle Aged Public health Vaccination - methods Vaccines Vesiculovirus - metabolism Young Adult Guinea Africa
ISSN:	0140-6736, 1474-547X
Online-Zugang:	Volltext
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