Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer

A hallmark of pancreatic ductal adenocarcinoma (PDAC) is the presence of a dense desmoplastic reaction (stroma) that impedes drug delivery to the tumor. Attempts to deplete the tumor stroma have resulted in formation of more aggressive tumors. We have identified signal transducer and activator of tr...

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Bibliographic Details
Published in:	Gastroenterology (New York, N.Y. 1943) Vol. 149; no. 7; p. 1932
Main Authors:	Nagathihalli, Nagaraj S, Castellanos, Jason A, Shi, Chanjuan, Beesetty, Yugandhar, Reyzer, Michelle L, Caprioli, Richard, Chen, Xi, Walsh, Alex J, Skala, Melissa C, Moses, Harold L, Merchant, Nipun B
Format:	Journal Article
Language:	English
Published:	United States 01.12.2015
Subjects:	Animals Antineoplastic Combined Chemotherapy Protocols - metabolism Antineoplastic Combined Chemotherapy Protocols - pharmacology Carcinoma, Pancreatic Ductal - drug therapy Carcinoma, Pancreatic Ductal - genetics Carcinoma, Pancreatic Ductal - metabolism Carcinoma, Pancreatic Ductal - mortality Carcinoma, Pancreatic Ductal - pathology Cell Line, Tumor Collagen - metabolism Deoxycytidine - analogs & derivatives Deoxycytidine - metabolism Deoxycytidine - pharmacology Drug Resistance, Neoplasm Gene Knockdown Techniques Humans Mice, Inbred C57BL Mice, Nude Mice, Transgenic Molecular Targeted Therapy Neoplasm Staging Osteonectin - metabolism Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - mortality Pancreatic Neoplasms - pathology Phosphorylation Protein-Serine-Threonine Kinases - genetics Proto-Oncogene Proteins p21(ras) - genetics Pyrazoles - metabolism Pyrazoles - pharmacology Pyrimidines - metabolism Pyrimidines - pharmacology Receptors, Transforming Growth Factor beta - genetics Signal Transduction - drug effects Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization STAT3 Transcription Factor - antagonists & inhibitors STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism Stromal Cells - drug effects Stromal Cells - metabolism Stromal Cells - pathology Time Factors Transcription Factors - genetics Transfection Tumor Burden Tumor Microenvironment Xenograft Model Antitumor Assays Stroma Tumor Microenvironment Pancreatic Cancer Drug Delivery
ISSN:	1528-0012, 1528-0012
Online Access:	Get more information
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