Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets

Understanding the neuropathology of multiple sclerosis (MS) is essential for improved therapies. Therefore, identification of targets specific to pathological types of MS may have therapeutic benefits. Here we identify, by laser-capture microdissection and proteomics, proteins unique to three major...

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Bibliographic Details
Published in:	Nature Vol. 451; no. 7182; pp. 1076 - 1081
Main Authors:	Han, May H., Hwang, Sun-Il, Roy, Dolly B., Lundgren, Deborah H., Price, Jordan V., Ousman, Shalina S., Fernald, Guy Haskin, Gerlitz, Bruce, Robinson, William H., Baranzini, Sergio E., Grinnell, Brian W., Raine, Cedric S., Sobel, Raymond A., Han, David K., Steinman, Lawrence
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 28.02.2008 Nature Publishing Nature Publishing Group
Subjects:	Adult Animals Anticoagulants Autoimmune diseases Biological and medical sciences Biomedical research Blood Coagulation Coagulation Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - metabolism Encephalomyelitis, Autoimmune, Experimental - pathology Female Gene Expression Profiling Humanities and Social Sciences Humans Inflammation - metabolism Inflammation - pathology Lasers Lesions Male Medical sciences Mice Middle Aged Molecular biology multidisciplinary Multiple sclerosis Multiple Sclerosis - classification Multiple Sclerosis - drug therapy Multiple Sclerosis - metabolism Multiple Sclerosis - pathology Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurology Protein C - genetics Protein C - metabolism Protein C - pharmacology Proteomics Science Science (multidisciplinary) Th1 Cells - immunology Th2 Cells - immunology Thrombin - antagonists & inhibitors Thrombin - metabolism Drug Nervous system diseases Target Multiple sclerosis Central nervous system disease Proteomics Lesion Inflammatory disease
ISSN:	0028-0836, 1476-4687, 1476-4687, 1476-4679
Online Access:	Get full text
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